Results 111 to 120 of about 5,123 (214)

Direct detection of an NH-π hydrogen bond in an intrinsically disordered peptide

Nature Communications
Hydrogen bonds play crucial roles in functional biomolecular dynamics. It is suggested that non-conventional hydrogen bonds engaging π electrons are prevalent in proteins. The experimental support for their existence is however limited.
Luigi Russo, Dipendu Dhar, Robin Backer, Om Prakash, Fatima Matroodi, Kerstin Overkamp, Karin Giller, Stefan Becker, Christian Griesinger, Dieter Willbold, Barbara Rossi, Mehdi D. Davari, Nasrollah Rezaei-Ghaleh   +12 more
doaj   +1 more source

Characterisation of the effects of intrinsically disordered protein (IDP)-solvent and IDP-lipid interactions in aqueous solution and lipid monolayers

, 2019
In dieser Arbeit wurde das Aggregationsverhalten zweier verschiedener Arten intrinsisch unstrukturierter Proteine untersucht. Zum einen wurde der Temperatur-abhängige inverse Phasenübergang von thermoresponsiven Peptid-Polymeren als Funktion der Aminosäuresequenz mit Elektronenspinresonanz- Spektroskopie untersucht.
openaire   +2 more sources

Intrinsically disordered proteins [PDF]

, 2016
Nativno neuređeni proteini i proteinske regije (​engl. intrinsically disordered proteins/regions, IDP/IDR) pripadaju nedavno priznatoj skupini proteina koji su biološki aktivni usprkos nedostatku jasno definirane trodimenzionalne strukture. Za razliku od
Tomljanović, Ingrid
core  

NMR spectroscopy of intrinsically disordered protein complexes

, 2016
Aufgrund der entscheidenden Rolle von intrinsisch ungeordneten Proteinen (IDP) in Proteininteraktionsnetzwerken stellen diese Proteine die Grundlage eines intensiven Forschungsfeldes dar.
Flamm, Andrea Gabriele
core  

Structural Regulation of a Neurofilament-Inspired Intrinsically Disordered Protein Brush by Multisite Phosphorylation

, 2018
Intrinsically disordered proteins (IDPs) play central roles in numerous cellular processes. While IDP structure and function are often regulated by multisite phosphorylation, the biophysical mechanisms linking these post-translational modifications to ...
Jessica P. Lee (2454346), Ruoxing Lei (4906861), Matthew B. Francis (425831), Sanjay Kumar (8853)   +3 more
core   +1 more source

Molecular Dynamics Simulations of a Powder Model of the Intrinsically Disordered Protein Tau.

, 2015
International audienceThe tau protein, whose aggregates are involved in Alzheimer's disease, is an intrinsically disordered protein (IDP) that regulates microtubule activity in neurons.
Zaccai, Giuseppe, Heyden, Matthias, Fichou, Yann, Tobias, Douglas J, Weik, Martin   +4 more
core   +2 more sources

Role of Ordered Proteins in the Folding-Upon-Binding of Intrinsically Disordered Proteins

, 2015
In this work, we quantitatively investigate the thermodynamic analogy between the folding of monomeric proteins and the interactions of intrinsically disordered proteins (IDPs).
Scott A. Showalter (111547), William G. Noid (1310550), Sushant Kumar (1310547), Chad W. Lawrence (1285953)   +3 more
core   +1 more source

Intrinsically disordered proteins studied by NMR spectroscopy

Journal of Magnetic Resonance Open
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of complex multi-domain proteins are now identified as a trend topic by the scientific community.
Marco Schiavina, Lorenzo Bracaglia, Tessa Bolognesi, Maria Anna Rodella, Giuseppe Tagliaferro, Angela Sofia Tino, Roberta Pierattelli, Isabella C. Felli   +7 more
doaj   +1 more source

Polymorph Crystal Selection by n16, an Intrinsically Disordered Nacre Framework Protein

, 2016
Framework proteins are a subclass of mollusk shell nacre-associated polypeptides that form supramolecular assemblies with β-chitin and other matrix proteins.
Christopher B. Ponce (2158324), John Spencer Evans (1326660)   +1 more
core   +1 more source

Intrinsically disordered energy landscapes.

, 2015
Analysis of an intrinsically disordered protein (IDP) reveals an underlying multifunnel structure for the energy landscape. We suggest that such 'intrinsically disordered' landscapes, with a number of very different competing low-energy structures, are ...

core   +1 more source