Results 111 to 120 of about 3,579,241 (217)

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, Volume 22, Issue 52, 16 September 2026.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Enhancing Binding Affinity of an Intrinsically Disordered Protein by α-Methylation of Key Amino Acid Residues [PDF]

, 2019
Intrinsically disordered proteins (IDPs), which undergo folding upon binding to their targets, are critical players in protein interaction networks.
Gilles, Travé, Natacha, Rochel, Vladimir, Torbeev, Camille, Kostmann, Bruno, Kieffer, Alexandra, Cousido-Siah, Boris, Schmidtgall, Gergő, Gógl, André, Mitschler, Judit, Osz, Jozica, Dolenc, Valentin, Bauer, Yves, Nominé   +12 more
core   +1 more source

Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow

Pharmacology & Therapeutics
The traditional model of protein structure determined by the amino acid sequence is today seriously challenged by the fact that approximately half of the human proteome is made up of proteins that do not have a stable 3D structure, either partially or in totality. These proteins, called intrinsically disordered proteins (IDPs), are involved in numerous
Jacques, Fantini, Fodil, Azzaz, Coralie, Di Scala, Anaïs, Aulas, Henri, Chahinian, Nouara, Yahi   +5 more
  +6 more sources

Deep Learning for Protein Modeling: From Single Structure to Bound Complex and Thermodynamic Ensemble, With a Focus on Architectural Design

WIREs Computational Molecular Science, Volume 16, Issue 5, September/October 2026.
Protein deep learning is moving from single structure prediction toward bound complex modeling and conformational ensemble generation. An architectural perspective shows how symmetry, evolutionary information, generative sampling, and energetic grounding shape performance and generalization.
Daniele Angioletti, Matteo Carli, Marco Nobile, Vittorio Limongelli   +3 more
wiley   +1 more source

Desiccation tolerance mechanisms in the green lineage and beyond

New Phytologist, Volume 251, Issue 6, Page 3159-3175, September 2026.
Ancient origin and recurrent evolution of desiccation tolerance in the green lineage. Summary Water is essential for life on Earth, yet some plants can survive the near‐complete loss of cellular water, a trait known as desiccation tolerance. Although rare in vegetative tissues of vascular plants, desiccation tolerance is scattered across the plant ...
Jenny Schuster, Robert VanBuren
wiley   +1 more source

Protocol for Investigating the Interactions Between Intrinsically Disordered Proteins and Membranes by Neutron Reflectometry

, 2020
Several intrinsically disordered proteins (IDPs) exhibit high affinity for lipid membranes. Among the different biophysical methods to probe protein-lipid interaction, neutron reflectometry (NR) can provide direct and structural detailed information on ...
Luchini A, Arleth L, Arleth, Lise, Lise Arleth, Luchini, Alessandra, Alessandra Luchini   +5 more
core   +1 more source

Direct detection of an NH-π hydrogen bond in an intrinsically disordered peptide

Nature Communications
Hydrogen bonds play crucial roles in functional biomolecular dynamics. It is suggested that non-conventional hydrogen bonds engaging π electrons are prevalent in proteins. The experimental support for their existence is however limited.
Luigi Russo, Dipendu Dhar, Robin Backer, Om Prakash, Fatima Matroodi, Kerstin Overkamp, Karin Giller, Stefan Becker, Christian Griesinger, Dieter Willbold, Barbara Rossi, Mehdi D. Davari, Nasrollah Rezaei-Ghaleh   +12 more
doaj   +1 more source

Computational modeling of intrinsically disordered and phase-separated protein states

Intrinsically disordered proteins possess ensembles of conformations and lack stable three-dimensional structures. Phase separation is defined as a phenomenon in which proteins and biomolecules, often including intrinsically disordered proteins, separate
Uversky, Vladimir N., Coskuner-Weber, Orkid   +1 more
core   +1 more source

Characterisation of the effects of intrinsically disordered protein (IDP)-solvent and IDP-lipid interactions in aqueous solution and lipid monolayers

, 2019
In dieser Arbeit wurde das Aggregationsverhalten zweier verschiedener Arten intrinsisch unstrukturierter Proteine untersucht. Zum einen wurde der Temperatur-abhängige inverse Phasenübergang von thermoresponsiven Peptid-Polymeren als Funktion der Aminosäuresequenz mit Elektronenspinresonanz- Spektroskopie untersucht.
openaire   +2 more sources

Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer’xxs and Parkinson’xxs diseases

, 2019
"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins.
Uversky, Vladimir N., Coşkuner Weber, Orkid   +1 more
core