Results 121 to 130 of about 4,606,382 (149)

[Intrinsically disordered proteins (IDPs) and the impact on cell stress resistance].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2022
Intrinsically disordered proteins (IDPs) are proteins or protein regions that fail to get folded into definite three-dimensional structures but participate in various biological processes and perform specific functions. Defying the traditional protein "sequence-structure-function" paradigm, they enrich the protein "structure-function" diversity ...
Ning, Yan, Hongxing, Li, Longhao, Wu, Shuo, Yang, Lujiang, Hao, Xiaoming, Bao   +5 more
openaire   +1 more source

Intrinsically disordered proteins (IDPs) studied by EPR and in-cell EPR

2018
Intrinsically disordered proteins (IDPs) play important physiological, but also disease-related roles. In order to understand the function and malfunction of proteins of this class, electron paramagnetic resonance (EPR) spectroscopy has proven to be a valuable tool, allowing investigation of the protein structural ensembles upon interaction with the ...
Sabrina Weickert, Julia Cattani, Malte Drescher   +2 more
openaire   +1 more source

Longitudinal Relaxation Properties of 1HN and 1Hα Determined by Direct-Detected 13C NMR Experiments to Study Intrinsically Disordered Proteins (IDPs)

Journal of Magnetic Resonance, 2015
Intrinsically disordered proteins (IDPs) are functional proteins containing large fragments characterized by high local mobility. Bioinformatic studies have suggested that a significant fraction (more than 30%) of eukaryotic proteins has disordered regions of more than 50 amino acids in length.
Bernhard Brutscher, Roberta Pierattelli, Tomáš Hošek   +2 more
exaly   +5 more sources

Molecular Bases of Salinity Resistance via Intrinsic Disordered Protein (IDP)

2023
Salt-affected soil is a prominent challenge in agriculture. Nowadays, more than 800 million hectares of land (about 6% of the world’s total land area) are induced with high salt concentrations, and thus, are unsuitable for growing typically salt-sensitive crop plants. The ongoing salinization of arable land exacerbates this limitation.
openaire   +2 more sources

A multi-responsive intrinsically disordered protein (IDP)-directed green synthesis of fluorescent gold nanoclusters

Journal of Materials Chemistry B, 2015
Herein we demonstrate the green synthesis of fluorescent gold nanoclusters (AuNCs) using a multi-responsive intrinsically disordered protein (IDP) polymer, Rec1-resilin, as a multi-functional template.
Balu, R., Bourgeois, L., Elvin, C., Hill, A., Choudhury, N., Dutta, N.   +5 more
openaire   +5 more sources

IDP-EDL: Enhancing Intrinsically Disordered Protein Prediction by Combining Protein Language Model and Ensemble Deep Learning

Briefings in Bioinformatics
Abstract Identification of intrinsically disordered regions (IDRs) in proteins is essential for understanding fundamental cellular processes. The IDRs can be divided into long disordered regions (LDRs) and short disordered regions (SDRs) according to their lengths.
Hang Wei, Xiaopeng Jin, Saisai Sun
exaly   +3 more sources

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Journal of Magnetic Resonance Open
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of complex multi-domain proteins are now identified as a trend topic by the scientific community.
Roberta Pierattelli, Lorenzo Bracaglia, Marco Schiavina   +2 more
exaly   +3 more sources

Exclusively Heteronuclear ¹³ C‐Detected Amino‐Acid‐Selective NMR Experiments for the Study of Intrinsically Disordered Proteins (IDPs)

ChemBioChem, 2012
Abstract Carbon‐13 direct‐detection NMR methods have proved to be very useful for the characterization of intrinsically disordered proteins (IDPs). Here we present a suite of experiments in which amino‐acid‐selective editing blocks are encoded in CACON‐ and CANCO‐type sequences to give 13
W. Bermel, BERTINI, IVANO, J. Chill, FELLI, ISABELLA CATERINA, N. Haba, MACHOHALLY VENKATESHAIAH, VASANTHA KUMAR, PIERATTELLI, ROBERTA   +6 more
openaire   +3 more sources

The gene expression profiling of hepatocellular carcinoma by a network analysis approach shows a dominance of intrinsically disordered proteins (IDPs) between hub nodes

Molecular BioSystems, 2015
Abstract We have analyzed the transcriptomic data from patients with hepatocellular carcinoma (HCC) after viral HCV infection at the various stages of the disease by means of a networking analysis using the publicly available E-MTAB-950 dataset.
Singh S, Colonna G, DI BERNARDO, Giovanni, Bergantino F, CAMMAROTA, Marcella, Castello G, Costantini S.   +6 more
openaire   +2 more sources

IDP-T5CKNN: Protein Language Models for Prediction of Intrinsically Disordered Proteins

Current Computer Science
Introduction: Disordered proteins (IDPs) and disordered protein regions (IDRs) have important roles in cellular signalling and regulation and in disease development. However, their flexible conformations create challenges in annotating them through computational methods.
openaire   +1 more source