Results 91 to 100 of about 5,123 (214)

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Rethinking Gene Regulatory Networks in Light of Alternative Splicing, Post-Translational Modifications, and Intrinsically Disordered Protein Domains

Frontiers in Cell and Developmental Biology, 2015
Models for genetic regulation and cell fate specification characteristically assume that gene regulatory networks (GRNs) are essentially deterministic and exhibit multiple stable states specifying alternate, but pre-figured cell fates. Mounting evidence
Karl J. Niklas, Sarah eBondos, A. Keith eDunker, Stuart A. Newman   +3 more
doaj   +1 more source

The Effect of Protein Tagging on Aggregation and Phase Separation

Journal of Cellular Biochemistry, Volume 127, Issue 6, June 2026.
ABSTRACT Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self‐assembly. This interference is particularly significant for intrinsically disordered proteins and low‐complexity domains, whose aggregation and phase separation are mediated by weak multivalent interactions that ...
Harunobu Saito, Kenji Sugase
wiley   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Lipid composition controls the huntingtin exon 1 membrane‐association and differentially modulates its flanking regions' dynamics

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The pathological expansion of the polyglutamine (polyQ) repeat within the first exon of huntingtin (Httex1) protein is a defining hallmark of Huntington's disease (HD). Multiple evidence supports that the membrane recruitment of Httex1 is critical for its self‐assembly and related toxicity in HD.
Tânia Sousa, Gonçalo Damas, Ana Coutinho, Nuno Bernardes, Ana Azevedo, Manuel Prieto, Ana M. Melo   +6 more
wiley   +1 more source

Dynamic disorder is crucial for mitochondrial protein import

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The import of proteins into mitochondria poses fundamental mechanistic challenges: aggregation‐prone precursor proteins must be maintained in aqueous compartments and threaded through narrow pores without becoming stuck or mislocalized. Recent evidence from mitochondrial protein import studies and other chaperone systems underscores the ...
Jakob Schneider, Undina Guillerm, Caroline Simões Pereira, Paul Schanda   +3 more
wiley   +1 more source

Sketching microprotein portraits

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The illustrations of intricate molecular machineries inside cells created by David Goodsell continue to inspire the scientific community. Here, we aim to extend his artworks to include microproteins, a newly recognized class of small proteins with less than 100 amino acids, encoded by small open reading frames.
Gabriel Diaz, Philippe Valenti, Marc Gueroult, Simon Marques‐Prieto, Kenza Benachenhou, Jennifer Zanet, Matthieu Chavent   +6 more
wiley   +1 more source

Apo-parvalbumin as an Intrinsically Disordered Protein

, 2008
Recently defined family of intrinsically disordered proteins (IDP) includes proteins lacking rigid tertiary structure meanwhile fulfilling essential biological functions. Here we show that apo-state of pike parvalbumin (α- and β-isoforms, pI 5.0 and 4.2,
Knyazeva, Ekaterina L., Uversky, Vladimir N., Denesyuk, Alexander I., Permyakov, Eugene A., Permyakov, Sergei E., Bakunts, Anush G.   +5 more
core   +1 more source

Intrinsically disordered inhibitor of glutamine synthetase is a functional protein with random-coil-like pKa values [PDF]

, 2017
The sequential action of glutamine synthetase (GS) and glutamate synthase (GOGAT) in cyanobacteria allows the incorporation of ammonium into carbon skeletons. In the cyanobacterium Synechocystis sp.
Concetta Cozza, Muro-Pastor, M. Isabel, Florencio, Francisco J., Cozza, Concetta, Francisco J. Florencio, M. Isabel Muro-Pastor, Florencio Bellido, Francisco Javier, Muro Pastor, María Isabel, Bruno Rizzuti, Neira, José L., Rizzuti, Bruno, José L. Neira   +11 more
core   +1 more source

Use of biomolecular emulator for characterizing flexible proteins by small‐angle x‐ray scattering

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Flexible proteins populate heterogeneous conformational ensembles that are essential for their function. Small‐angle x‐ray scattering (SAXS) is widely used to study protein structure in solution and to characterize conformational heterogeneity.
Yoni Haitin, Bar Manori, Moshe Giladi
wiley   +1 more source