Mechanisms of change in protein architecture [PDF]
, 2011 Proteins are the basic building blocks and functional units in all living organisms. Moreover, differences between species can frequently be explained with differences in their protein complements.
core +2 more sources
Biomolecules, 2021 Intrinsic disorder plays an important functional role in proteins. Disordered regions are linked to posttranslational modifications, conformational switching, extra/intracellular trafficking, and allosteric control, among other phenomena.
David Ortega-Alarcon +6 more
doaj +1 more source
Long-Range Entropic Effects on Protein Intrinsically Disordered Regions [PDF]
, 2019 Entropy calculations represent one of the most challenging steps in obtaining the binding free energy in proteins and their complexes, which is a grand challenge in computational biology.
Agnieszka K., Bronowska +3 more
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Troubleshooting Guide to Expressing Intrinsically Disordered Proteins for Use in NMR Experiments
Frontiers in Molecular Biosciences, 2019 Intrinsically disordered proteins (IDPs) represent a structural class of proteins that do not have a well-defined, 3D fold in solution, and often have little secondary structure.
Steffen P. Graether
doaj +1 more source
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
Scientific Reports, 2022 AlphaFold 2 (AF2) has placed Molecular Biology in a new era where we can visualize, analyze and interpret the structures and functions of all proteins solely from their primary sequences. We performed AF2 structure predictions for various protein systems,
Hao-Bo Guo +12 more
doaj +1 more source
Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery [PDF]
Drug Designing & Intellectual Properties International Journal, 2018 Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as Parkinson disease, Alzheimer disease, diabetes, and so on.
openaire +1 more source
Diverging Liquid–Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins
Advanced Science, EarlyView.Fibers spun from the MaSp1‐derivative as well as MaSp1‐MaSp2‐mixtures provide a deeper insight into the assembly process of the spidroins and how hierarchical architectures of spider silk fibers could be achieved. ABSTRACT Spider silk fibers show exceptional mechanical properties, based on their underlying spider silk proteins (spidroins) as well as a ...
Tim Schiller +2 more
wiley +1 more source
IDP-Bert: Predicting Properties of Intrinsically Disordered Proteins Using Large Language Models
The Journal of Physical Chemistry B22 pages, 5 ...
Parisa Mollaei +3 more
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Dynamics of proteins with different molecular structures under solution condition
Scientific Reports, 2020 Incoherent quasielastic neutron scattering (iQENS) is a fascinating technique for investigating the internal dynamics of protein. However, low flux of neutron beam, low signal to noise ratio of QENS spectrometers and unavailability of well-established ...
Rintaro Inoue +12 more
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α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, EarlyView.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel +10 more
wiley +1 more source