Results 61 to 70 of about 1,883,575 (282)

Templated folding of intrinsically disordered proteins [PDF]

, 2020
Much of our current knowledge of biological chemistry is founded in the structure-function relationship, whereby sequence determines structure that determines function. Thus, the discovery that a large fraction of the proteome is intrinsically disordered,
Troilo F., Brunori M., Malagrino Francesca, Jemth P., Gianni S., Visconti L., Pagano L., Toto A.   +7 more
core   +2 more sources

Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

Biomolecules, 2021
Motifs within proteins help us categorize their functions. Intrinsically disordered proteins (IDPs) are rich in short linear motifs, conferring them many different roles.
Estella A. Newcombe, Catarina B. Fernandes, Jeppe E. Lundsgaard, Inna Brakti, Kresten Lindorff-Larsen, Annette E. Langkilde, Karen Skriver, Birthe B. Kragelund   +7 more
doaj   +1 more source

Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle [PDF]

, 2007
The potent immunomodulatory, anti-inflammatory and procoagulant properties of the protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have been previously found to be modulated by a supramolecular monomer-trimer ...
Silvia Vilasi, Raffaele Ragone, Silvia Vilasi, AND RAGONE R., VILASI, SILVIA   +4 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Influence of sequence changes and environment on intrinsically disordered proteins. [PDF]

PLoS Computational Biology, 2009
Many large-scale studies on intrinsically disordered proteins are implicitly based on the structural models deposited in the Protein Data Bank. Yet, the static nature of deposited models supplies little insight into variation of protein structure and ...
Amrita Mohan, Vladimir N Uversky, Predrag Radivojac   +2 more
doaj   +1 more source

Development of Charge-Augmented Three-Point Water Model (CAIPi3P) for Accurate Simulations of Intrinsically Disordered Proteins [PDF]

, 2019
Intrinsically disordered proteins (IDPs) are molecules without a fixed tertiary structure, exerting crucial roles in cellular signalling, growth and molecular recognition events. Due to their high plasticity, IDPs are very challenging in experimental and
Agnieszka K., Bronowska, Joao Victor, de Souza Cunha, Francesc, Sabanes Zariquiey   +2 more
core   +1 more source

Intrinsically Disordered Synthetic Polymers in Biomedical Applications [PDF]

, 2023
In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility.
Uversky, Vladimir N., Yüce-Erarslan, Elif, Coşkuner Weber, Orkid, Elif Yuce-Erarslan, Kasem, Haytam, Abraham (Avi) J. Domb, Vladimir N. Uversky, Orkid Coskuner-Weber, Domb, Abraham (Avi) J., Haytam Kasem, Coskuner-Weber, Orkid   +10 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Networks of interbasin traffic in intrinsically disordered proteins

Physical Review Research, 2020
The equilibrium dynamics of the intrinsically disordered proteins is thought to consist of transitions between many basins in the free energy landscape whereas structured proteins stay in the vicinity of one native basin.
Belisa R. H. de Aquino, Mateusz Chwastyk, Łukasz Mioduszewski, Marek Cieplak   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source