Results 151 to 160 of about 23,829 (240)

Identification of inhibitors of biological interactions involving intrinsically disordered proteins

, 2015
Protein-protein interactions involving disordered partners have unique features and represent prominent targets in drug discovery processes. Intrinsically Disordered Proteins (IDPs) are involved in cellular regulation, signaling and control: they bind to
Daniela Marasco, Pasqualina Scognamiglio, Marasco D., MARASCO, DANIELA, SCOGNAMIGLIO, PASQUALINA LIANA, Pasqualina Liana Scognamiglio, Scognamiglio P. L.   +6 more
core   +1 more source

Disordered proteins interact with the chemical environment to tune their protective function during drying

eLife
The conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins, combined with the exposure of their residues, accounts for this ...
Shraddha KC, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Paulette Sofia Romero-Perez, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby   +9 more
doaj   +1 more source

Label-free optical observation of disordered-to-ordered transitions in single intrinsically disordered proteins. [PDF]

NPJ Biosens
Zargarbashi S, Dominguez C, Peters M, Yousefi A, Munday S, Wang Y, Chatterjee S, Hudson AJ, Gordon R, Mellor CJ, Xu L, Rahmani M, Ying C.   +12 more
europepmc   +2 more sources

Role of charges in a dynamic disordered complex between an IDP and a folded domain

Nature Communications
Protein complexes involving intrinsically disordered proteins (IDPs) cover a continuum from IDPs that fully fold upon binding to IDPs that remain fully disordered in the complex. Here we demonstrate a case of charge-driven interactions of a folded domain
Katrine Bugge, Andrea Sottini, Miloš T. Ivanović, Freia S. Buus, Daniel Saar, Catarina B. Fernandes, Fabienne Kocher, Jacob H. Martinsen, Benjamin Schuler, Robert B. Best, Birthe B. Kragelund   +10 more
doaj   +1 more source

Programming cellular condensates for living materials using an intrinsically disordered protein display platform (iDP ² )

Abstract Self-organization of multicellular systems is vital for building structure in living system but remains underexplored in engineered living materials. We developed iDP 2 , a platform enabling high-density display of intrinsically disordered proteins on the surface of
Rong Chang, Hann Tu, Neel S. Joshi
openaire   +1 more source

No Time to Fold: Intrinsically Disordered Microproteins in Action. [PDF]

Biochemistry
Chen T, Cao K, Martinez TF.
europepmc   +1 more source

Current stage and future perspectives for homology modeling, molecular dynamics simulations, machine learning with molecular dynamics, and quantum computing for intrinsically disordered proteins and proteins with intrinsically disordered regions

The structural ensembles of intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) cannot be easily characterized using conventional experimental techniques.
Uversky, Vladimir N., Coşkuner Weber, Orkid   +1 more
core   +1 more source

Chaotic aging: Intrinsically disordered proteins in aging-related processes

bioRxiv, 2023
Vladimir D. Manyilov, N. Ilyinsky, S. Nesterov, B. M. Saqr, Guy W. Dayhoff, Egor V. Zinovev, Simon S. Matrenok, A. Fonin, I. Kuznetsova, K. Turoverov, V. Ivanovich, V. Uversky   +11 more
semanticscholar   +1 more source

EXPLORING THE COMPLEX LANDSCAPE OF PROTEINS: FROM INTRINSICALLY DISORDERED PROTEINS TO PEPTIDOMIMETICS THROUGH COMPUTATIONAL APPROACHES

Protein function is closely related to their three-dimensional structures. However, some proteins lack a well-defined structure, so-called intrinsically disordered proteins (IDPs).
Li, Tongtong
core  

A Native Nepenthesin Reactor for Improved Proteolytic Digestion of Intrinsically Disordered Proteins in Proteomics Workflows. [PDF]

Chembiochem
Wall C, Hause F, Grimm W, Otto FW, Siefke E, Kipping M, Sinz A.   +6 more
europepmc   +1 more source