Results 131 to 140 of about 23,829 (240)

Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow

Pharmacology & Therapeutics
The traditional model of protein structure determined by the amino acid sequence is today seriously challenged by the fact that approximately half of the human proteome is made up of proteins that do not have a stable 3D structure, either partially or in totality. These proteins, called intrinsically disordered proteins (IDPs), are involved in numerous
Jacques, Fantini, Fodil, Azzaz, Coralie, Di Scala, Anaïs, Aulas, Henri, Chahinian, Nouara, Yahi   +5 more
  +6 more sources

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Opportunities and challenges in protein structure prediction

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Deep learning methods, particularly exemplified by AlphaFold2, have revolutionized the field of protein structure prediction—an achievement recognized by the 2024 Nobel Prize in Chemistry awarded to its core developers. Despite this remarkable achievement, the broader protein folding problem is far from solved. Key challenges—each representing
Wenkai Wang, Baoquan Su, Chenxiao Xiang, Jianyi Yang   +3 more
wiley   +1 more source

A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction

Nature Communications, 2018
How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl ...
Franziska Zosel, Davide Mercadante, Daniel Nettels, Benjamin Schuler   +3 more
doaj   +1 more source

On‐Chip Evaluation of Red Blood Cell Deformability Through Transit Velocity Index in Hematological Diseases

Small, Volume 22, Issue 33, 12 June 2026.
The deformability of red blood cell is essential for smooth microcirculation. We propose a deformability index using a microfluidic platform with capillary‐like constrictions, based on the relationship between cell deformation and transit velocity through the constrictions. Its effectiveness and clinical potential have been demonstrated in applications
Kenji Kajitani, Chia‐Hung Dylan Tsai, Tomohito Ohtani, Shigeo Wada, Ivan Cimrák, Misato Chimura, Tatsunori Taniguchi, Yasutaka Ueda, Jun‐ichi Nishimura, Yasushi Sakata   +9 more
wiley   +1 more source

IDP-EDL: enhancing intrinsically disordered protein prediction by combining protein language model and ensemble deep learning

Briefings in Bioinformatics
Abstract Identification of intrinsically disordered regions (IDRs) in proteins is essential for understanding fundamental cellular processes. The IDRs can be divided into long disordered regions (LDRs) and short disordered regions (SDRs) according to their lengths.
Junxi Xie, Xiaopeng Jin, Hang Wei, SaiSai Sun, Yumeng Liu   +4 more
openaire   +2 more sources

Denaturant-Induced Conformational Transitions in Intrinsically Disordered Proteins

, 2012
Intrinsically disordered proteins (IDPs) differ from ordered proteins at several levels: structural, functional, and conformational. Amino acid biases also drive atypical responses of IDPs to changes in their environ- ment.
Ciurli, Stefano, V. N. Uversky, NEYROZ, PAOLO, Uversky, Vladimir N., Paolo Neyroz, Stefano Ciurli, CIURLI, STEFANO LUCIANO, Vladimir N. Uversky   +7 more
core   +1 more source

Therapeutic Peptide SS‐31 Modulates Membrane Binding and Aggregation of α‐Synuclein and Restores Impaired Mitochondrial Function

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
SS‐31 (Elamipretide) inhibits α‐synuclein aggregation on the membranes and emerges as a promising therapeutic candidate against mitochondrial dysfunction in Parkinson's disease. ABSTRACT Membrane binding and aggregation properties of α‐synuclein are closely associated with Parkinson's disease and a class of related syndromes named as synucleinopathy ...
Ewelina Stefaniak, Beiyuan Cui, Xucheng Yan, Kexin Sun, Xiangyu Teng, Liming Ying   +5 more
wiley   +1 more source

Diffusion-limited association of disordered protein by non-native electrostatic interactions

Nature Communications, 2018
Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins which involves the formation of a transient complex (TC). Here authors use single-molecule FRET to show that the lifetime of TC for IDP binding is very long due to ...
Jae-Yeol Kim, Fanjie Meng, Janghyun Yoo, Hoi Sung Chung   +3 more
doaj   +1 more source

Recent Advances in Computational Protocols Addressing Intrinsically Disordered Proteins

Biomolecules, 2019
Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently emerged as major therapeutic targets for various diseases. Unlike traditional proteins that adopt a definitive structure, IDPs in free solution are disordered and ...
Supriyo Bhattacharya, Xingcheng Lin
doaj   +1 more source