Results 111 to 120 of about 23,829 (240)

Mechanisms of small-molecule binding to intrinsically disordered proteins [PDF]

, 2012
IDPs (intrinsically disordered proteins) play crucial roles in many important cellular processes such as signalling or transcription and are attractive therapeutic targets for several diseases.
Michel, Julien, Cuchillo, Remi
core   +1 more source

An ETL pipeline to construct the Intrinsically Disordered Proteins Knowledge Graph (IDP-KG) using Bioschemas JSON-LD data dumps

, 2022
Schema.org and Bioschemas are lightweight vocabularies that aim at making the contents of web pages machine-readable so that software agents can consume that content and understand it in an actionable way. Due to the time needed to process each page, extracting markup by visiting each page of a site is not practical for huge sites.
Ammar Ammar, Ivan Mičetić, Alasdair J. G. Gray   +2 more
openaire   +1 more source

Charge interactions can dominate the dimensions of intrinsically disordered proteins

, 2010
Many eukaryotic proteins are disordered under physiological conditions, and fold into ordered structures only on binding to their cellular targets. Such intrinsically disordered proteins (IDPs) often contain a large fraction of charged amino acids. Here,
Nettels, D, Müller-Späth, Sonja, Reymond, Luc, Verena Hirschfeld, Hagen Hofmann, Rüegger, Stefan, Müller-Späth, S, Andrea Soranno, Daniel Nettels, Nettels, Daniel, Rüegger, S, Hirschfeld, Verena, Hirschfeld, V, Soranno, Andrea, Hofmann, Hagen, Stefan Rüegger, Benjamin Schuler, Hofmann, H, Schuler, Benjamin, Reymond, L, Schuler, B, Sonja Müller-Späth, Soranno, A, Luc Reymond   +23 more
core   +1 more source

Protein Disorder in Plant Stress Adaptation: From Late Embryogenesis Abundant to Other Intrinsically Disordered Proteins

International Journal of Molecular Sciences
Global climate change has caused severe abiotic and biotic stresses, affecting plant growth and food security. The mechanical understanding of plant stress responses is critical for achieving sustainable agriculture.
A. Hsiao
semanticscholar   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

The Effect of Protein Tagging on Aggregation and Phase Separation

Journal of Cellular Biochemistry, Volume 127, Issue 6, June 2026.
ABSTRACT Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self‐assembly. This interference is particularly significant for intrinsically disordered proteins and low‐complexity domains, whose aggregation and phase separation are mediated by weak multivalent interactions that ...
Harunobu Saito, Kenji Sugase
wiley   +1 more source

Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders

, 2015
The recent years have witnessed a rise in the number of intrinsically disor-dered proteins (IDPs), also known as hybrid proteins, which possess both struc-tured domains and biologically important intrinsically disordered protein regions (IDPRs).
Uversky, Vladimir N., Vladimir N. Uversky   +1 more
core   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Protocol for Investigating the Interactions Between Intrinsically Disordered Proteins and Membranes by Neutron Reflectometry

, 2020
Several intrinsically disordered proteins (IDPs) exhibit high affinity for lipid membranes. Among the different biophysical methods to probe protein-lipid interaction, neutron reflectometry (NR) can provide direct and structural detailed information on ...
Luchini A, Arleth L, Arleth, Lise, Lise Arleth, Luchini, Alessandra, Alessandra Luchini   +5 more
core   +1 more source

How to drug a cloud? Targeting intrinsically disordered proteins.

Pharmacological Reviews
Biologically active proteins/regions without stable structure (i.e., intrinsically disordered proteins and regions (IDPs and IDRs)) are commonly found in all proteomes.
V. Uversky
semanticscholar   +1 more source