Results 91 to 100 of about 23,171 (195)

Spatial Statistics for Screening Molecular Structures

Small, EarlyView.
Deep architectures for materials discovery demand vast training data and obscure the structure‐property link. This review shows how spatial statistics offer a physically grounded alternative: voxelized fields and two‐point correlations, compressed by principal component analysis, yield convex, interpretable descriptors. Lean surrogates then reach sub‐2%
Pranoy Ray, Surya R. Kalidindi
wiley   +1 more source

Atomic resolution ensembles of intrinsically disordered proteins with Alphafold

bioRxiv
Intrinsically disordered proteins are ubiquitous in biological systems and play essential roles in a wide range of biological processes and diseases.
Vincent Schnapka, Tatiana I. Morozova, Samiran Sen, Massimiliano Bonomi   +3 more
semanticscholar   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

Ensemble docking for intrinsically disordered proteins

bioRxiv
Intrinsically disordered proteins (IDPs) are implicated in many human diseases and are increasingly being pursued as drug targets. Conventional structure-based drug design methods that rely on well-defined binding sites are however, largely unsuitable ...
A. Dhar, Thomas R. Sisk, Paul J. Robustelli   +2 more
semanticscholar   +1 more source

Intrinsically Disordered Proteins in Cellular Signaling and Regulation

Nature reviews. Molecular cell biology, 2014
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling machinery, allowing the same polypeptide to undertake different interactions with different consequences.
Peter E. Wright, H. Dyson
semanticscholar   +1 more source

An ETL pipeline to construct the Intrinsically Disordered Proteins Knowledge Graph (IDP-KG) using Bioschemas JSON-LD data dumps

, 2022
Schema.org and Bioschemas are lightweight vocabularies that aim at making the contents of web pages machine-readable so that software agents can consume that content and understand it in an actionable way. Due to the time needed to process each page, extracting markup by visiting each page of a site is not practical for huge sites.
Ammar Ammar, Ivan Mičetić, Alasdair J. G. Gray   +2 more
openaire   +1 more source

Protein Disorder in Plant Stress Adaptation: From Late Embryogenesis Abundant to Other Intrinsically Disordered Proteins

International Journal of Molecular Sciences
Global climate change has caused severe abiotic and biotic stresses, affecting plant growth and food security. The mechanical understanding of plant stress responses is critical for achieving sustainable agriculture.
An-Shan Hsiao
semanticscholar   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, Volume 38, Issue 59, 22 October 2026.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Binding mechanisms of intrinsically disordered proteins: Insights from experimental studies and structural predictions.

Current Opinion in Structural Biology
Advances in the characterization of intrinsically disordered proteins (IDPs) have unveiled a remarkably complex and diverse interaction landscape, including coupled folding and binding, highly dynamic complexes, multivalent interactions, and even ...
Thibault Orand, M. R. Jensen
semanticscholar   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source