Results 81 to 90 of about 1,763,945 (204)

Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome [PDF]

, 2013
A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame.
Kalmár, Lajos, Schád, Éva, Tompa, Péter   +2 more
core   +1 more source

Nuclear‐Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra‐High Field

Journal of the Chinese Chemical Society, EarlyView.
This study shows that the sensitivity of liquid‐state NMR spectroscopy can be dramatically increased, with enhancement factors up to 160‐fold on a 1.1 GHz ultra‐high‐field NMR spectrometer. This advance exploits low‐concentration photochemically induced dynamic nuclear polarization (LC‐photo‐CIDNP) and it enables facile atomic‐resolution detection of ...
Ji Ho Jeong, Anubhab Halder, Silvia Cavagnero   +2 more
wiley   +1 more source

Empirical predictions of an intrinsically disordered protein theory approach to glycan/lectin reaction kinetics [PDF]

, 2012
Newly-developed methods from the theory of intrinsically disordered proteins can be applied to the flexible glycan structures that coat cellular surfaces and provide rich channels for biological information transmission.
Rodrick Wallace
core  

The binding mechanisms of intrinsically disordered proteins [PDF]

, 2014
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins are very common and instrumental for cellular signaling.
Gianni, Stefano, Jemth, Per, Jemth P., Dogan, Jakob, Dogan J, Dogan, Jakob,, Jemth, Per,   +6 more
core   +1 more source

Residue packing in globular and intrinsically disordered proteins

, 2018
Intrinsically disordered proteins (IDPs)/regions do not have well-defined secondary and tertiary structures, however, they are functional and it is critical to gain a deep understanding of their residue packing. The shape distributions methodology, which
Elife Zerrin Bagci, Rasim Murat Aydinkal, Aydinkal, R.M., Bağcı, Elife Zerrin   +3 more
core   +2 more sources

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, EarlyView.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Self-organization of intrinsically disordered proteins with folded N-termini [PDF]

, 2010
Thousands of human proteins lack recognizable tertiary structure in most of their chains. Here we hypothesize that some use their structured N-terminal domains (SNTDs) to organise the remaining protein chain via intramolecular interactions, generating ...
Philip C. Simister, Simon McGowan, Nicola O'Reilly, Stephan M. Feller, Fred Schaper   +4 more
core  

Cold stability of intrinsically disordered proteins [PDF]

, 2009
Contrary to globular proteins, intrinsically disordered proteins (IDPs) lack a folded structure and they do not lose solubility at elevated temperatures. Although this should also be true at low temperatures, cold stability of IDPs has not been addressed
Friedrich, Peter, Tantos, Agnes, Tompa, Peter   +2 more
core   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source