Results 101 to 110 of about 1,763,945 (204)

Experimental methods to study the structure and dynamics of intrinsically disordered regions in proteins

Current Research in Structural Biology
Eukaryotic proteins often feature long stretches of amino acids that lack a well-defined three-dimensional structure and are referred to as intrinsically disordered proteins (IDPs) or regions (IDRs).
Snigdha Maiti, Aakanksha Singh, Tanisha Maji, Nikita V. Saibo, Soumya De   +4 more
doaj   +1 more source

Inherent α‐Helix Around Tyrosine 183 in the Intrinsically Disordered Tail of the Multi‐Site Docking Platform Gab1

Biopolymers, Volume 117, Issue 5, September 2026.
The two phosphorylation sites within the Gab1 fragment 142‐203 exhibit distinct structural characteristics. Tyr162 is in a disordered region, Y183 in a helical segment. ABSTRACT The biological function of intrinsically disordered proteins is frequently coupled to short linear motifs, which serve as protein binding sites.
Anne Dietrich, Marc Lewitzky, Tobias Gruber, Jochen Balbach, Stephan M. Feller, Ulrich Weininger   +5 more
wiley   +1 more source

Toward a consensus in protein structure nomenclature

, 2019
In a recent article, published in Intrinsically Disordered Proteins, a valuable consensus view regarding the nomenclature for disordered proteins was presented.1 In this work the authors present a thoughtful and systemic review of terms that have been ...
DaSilva, Linder C, Gurry, Thomas Jerome, Stultz, Collin M   +2 more
core   +1 more source

Data–driven Modelling of Intrinsically Disordered Proteins [PDF]

, 2019
In this thesis we investigated the relationships between amino acid sequence and biophysical properties of intrinsically disordered proteins involved in Parkinson's and Alzheimer's disease (IDPs), gauged from NMR ...
Tamiola, Kamil
core   +1 more source

Programming Multidomain Peptides With Molecular Frustration Into Biomolecular Condensates

Small, Volume 22, Issue 51, 11 September 2026.
De novo designed multidomain peptides (MDPs) were used to explore how molecular ordering influences peptide phase behavior. MDPs containing partially folded β‐sheets were found to form biomolecular condensates. This work introduces a new design principle for condensate formation and expand the design space beyond conventional intrinsically disordered ...
Debdatta Das, Jenny N. Nguyen, Navneet Sahoo, Chuanye Xiong, Haritha Asokan‐Sheeja, Yan Chang, Raniyah Ali, Eleanor D. Smith, Chad A. Brautigam, Yi Hong, Zui Pan, Peng Tao, He Dong   +12 more
wiley   +1 more source

Illuminating Intrinsically Disordered Proteins with Integrative Structural Biology

, 2023
Intense study of intrinsically disordered proteins (IDPs) did not begin in earnest until the late 1990s when a few groups, working independently, convinced the community that these ‘weird’ proteins could have important functions.
Sravani Ramisetty, Keith Weninger, Rachel Evans, Prakash Kulkarni   +3 more
core   +1 more source

Deep Learning for Protein Modeling: From Single Structure to Bound Complex and Thermodynamic Ensemble, With a Focus on Architectural Design

WIREs Computational Molecular Science, Volume 16, Issue 5, September/October 2026.
Protein deep learning is moving from single structure prediction toward bound complex modeling and conformational ensemble generation. An architectural perspective shows how symmetry, evolutionary information, generative sampling, and energetic grounding shape performance and generalization.
Daniele Angioletti, Matteo Carli, Marco Nobile, Vittorio Limongelli   +3 more
wiley   +1 more source

Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders [PDF]

, 2015
The recent years have witnessed a rise in the number of intrinsically disor-dered proteins (IDPs), also known as hybrid proteins, which possess both struc-tured domains and biologically important intrinsically disordered protein regions (IDPRs).
Uversky, Vladimir N., Vladimir N. Uversky   +1 more
core   +1 more source

Desiccation tolerance mechanisms in the green lineage and beyond

New Phytologist, Volume 251, Issue 6, Page 3159-3175, September 2026.
Ancient origin and recurrent evolution of desiccation tolerance in the green lineage. Summary Water is essential for life on Earth, yet some plants can survive the near‐complete loss of cellular water, a trait known as desiccation tolerance. Although rare in vegetative tissues of vascular plants, desiccation tolerance is scattered across the plant ...
Jenny Schuster, Robert VanBuren
wiley   +1 more source

Charge interactions can dominate the dimensions of intrinsically disordered proteins [PDF]

, 2010
Many eukaryotic proteins are disordered under physiological conditions, and fold into ordered structures only on binding to their cellular targets. Such intrinsically disordered proteins (IDPs) often contain a large fraction of charged amino acids. Here,
Nettels, D, Müller-Späth, Sonja, Reymond, Luc, Verena Hirschfeld, Hagen Hofmann, Rüegger, Stefan, Müller-Späth, S, Andrea Soranno, Daniel Nettels, Nettels, Daniel, Rüegger, S, Hirschfeld, Verena, Hirschfeld, V, Soranno, Andrea, Hofmann, Hagen, Stefan Rüegger, Benjamin Schuler, Hofmann, H, Schuler, Benjamin, Reymond, L, Schuler, B, Sonja Müller-Späth, Soranno, A, Luc Reymond   +23 more
core   +1 more source