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Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs
Journal of Clinical Laboratory Analysis, EarlyView.Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo +5 more
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Invariant natural killer T cells as sensors and managers of inflammation [PDF]
Trends in Immunology, 2013 Invariant natural killer T (iNKT) cells are a subset of innate-like lymphocytes that recognize glycolipid antigens bound by the major histocompatibility complex (MHC)-class-I-related protein CD1d. iNKT cells are activated early during a variety of infections and inflammatory diseases and contribute to the subsequent development of adaptive immune ...
Luc Van Kaer, Vrajesh V Parekh, Lan Wu
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Analysis of Invariant Natural Killer T Cells in Human Paracoccidioidomycosis
Mycopathologia, 2011Invariant natural killer T (iNKT) cells are capable of recognizing lipid antigens and secreting Th1/Th2 cytokines. Deficiency in iNKT cell number or function has been partially implicated in susceptibility to some infectious diseases, such as tuberculosis.
Batista V., Gomes +3 more
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Invariant Natural Killer T Cell-Based Immunotherapy for Cancer
Immunotherapy, 2008Human Valpha24 invariant natural killer T (iNKT) cells are a distinct lymphocyte population, characterized by an invariant T-cell receptor Valpha24 chain paired mainly with Valpha11. Valpha24 iNKT cells are activated by a glycolipid ligand - alpha-galactosylceramide - and produce a large amount of Th1 and Th2 cytokines, thereby modulating the function ...
Shinichiro, Motohashi +1 more
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Human invariant natural killer T cells: implications for immunotherapy
International Journal of Hematology, 2009Human invariant natural killer T cells are a unique lymphocyte population that have an invariant T-cell receptor and recognize glycolipids instead of peptides in the restriction of CD1d molecules. These natural killer T cells play important roles in anti-tumor immunity, transplantation immunity, allergy, autoimmunity and microbial immunity. Since human
Tsuyoshi, Takahashi, Mineo, Kurokawa
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CD4+ Invariant T-Cell–Receptor+ Natural Killer T Cells in Bronchial Asthma
New England Journal of Medicine, 2006Bronchial asthma is associated with an inflammatory process that is characterized by the presence in the airways of large numbers of CD4+ T cells producing interleukin-4 and interleukin-13. However, the CD4 antigen is expressed not only by class II major histocompatibility complex (MHC)-restricted CD4+ T cells, but also by a newly identified subgroup ...
Omid, Akbari +7 more
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Invariant natural killer T cells in multiple sclerosis
2013Invariant natural killer T (iNKT) cells are a subpopulation of lymphocytes that express both a CD1d-restricted αβ T cell receptor (TCR) and NK cell markers. iNKT cell perturbations are implicated in a wide variety of autoimmune diseases including Multiple Sclerosis (MS).
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Invariant Natural Killer T Cells in Obstructive Pulmonary Diseases
New England Journal of Medicine, 2007Omid, Akbari +2 more
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