Results 41 to 50 of about 1,742,420 (301)

Propensity Score Methods in Rhinologic Observational Research: Principles, Applications, Extensions, and Practical Considerations [PDF]

Journal of Rhinology
Randomized controlled trials (RCTs) remain the gold standard for evaluating treatment efficacy because randomization minimizes measured and unmeasured confounding.
Jae Hoon Cho
doaj   +1 more source

Impact of acute cholecystitis comorbidity on prognosis after surgery for gallbladder cancer: a propensity score analysis

World Journal of Surgical Oncology, 2023
Background Cholecystitis can represent a comorbidity during gallbladder cancer surgery; nonetheless, the prognostic impact of acute cholecystitis comorbidity remains unclear.
Yasuhiro Kihara, Hiroshi Yokomizo, Kenta Murotani   +2 more
doaj   +1 more source

Is inverse probability of censoring weighting a safer choice than per-protocol analysis in clinical trials? [PDF]

Deviation from the treatment strategy under investigation occurs in many clinical trials. We term this intervention deviation. Per-protocol analyses are widely adopted to estimate a hypothetical estimand without the occurrence of intervention deviation ...
Malbecq, William, Bell Gorrod, H., Vandormael, Kristel, Mt-Isa, Shahrul, Yorke-Edwards, V., White, I.R., Xuan, Jingyi, Xuan, J., Latimer, Nicholas, Yorke-Edwards, Victoria, White, Ian R, Malbecq, W., Latimer, N., Vandormael, K., Bell Gorrod, Helen, Mt-Isa, S.   +15 more
core   +4 more sources

Unicompartmental compared with total knee replacement for patients with multimorbidities: a cohort study using propensity score stratification and inverse probability weighting

Health Technology Assessment, 2021
Background: Although routine NHS data potentially include all patients, confounding limits their use for causal inference. Methods to minimise confounding in observational studies of implantable devices are required to enable the evaluation of patients ...
Albert Prats-Uribe, Spyros Kolovos, Klara Berencsi, Andrew Carr, Andrew Judge, Alan Silman, Nigel Arden, Irene Petersen, Ian J Douglas, J Mark Wilkinson, David Murray, Jose M Valderas, David J Beard, Sarah E Lamb, M Sanni Ali, Rafael Pinedo-Villanueva, Victoria Y Strauss, Daniel Prieto-Alhambra   +17 more
doaj   +1 more source

Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study

Trials, 2019
Background Randomized trials are considered the gold standard for making inferences about the causal effects of treatments. However, when protocol deviations occur, the baseline randomization of the trial is no longer sufficient to ensure unbiased ...
Jessica G. Young, Rajet Vatsa, Eleanor J. Murray, Miguel A. Hernán   +3 more
doaj   +1 more source

Modeling Secondary Phenotypes Conditional on Genotypes in Case–Control Studies

Stats, 2022
Traditional case–control genetic association studies examine relationships between case–control status and one or more covariates. It is becoming increasingly common to study secondary phenotypes and their association with the original covariates.
Naomi C. Brownstein, Jianwen Cai, Shad Smith, Luda Diatchenko, Gary D. Slade, Eric Bair   +5 more
doaj   +1 more source

IPWLOGIT: Stata module to fit marginal logistic regression by inverse probability weighting

, 2023
IPWLOGIT fits marginal logistic regression of a binary dependent variable on a treatment variable, possibly adjusting for control variables by inverse probability weighting (IPW).
Jann, Ben
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Constructing Inverse Probability Weights for Marginal Structural Models [PDF]

American Journal of Epidemiology, 2008
The method of inverse probability weighting (henceforth, weighting) can be used to adjust for measured confounding and selection bias under the four assumptions of consistency, exchangeability, positivity, and no misspecification of the model used to estimate weights.
Stephen R, Cole, Miguel A, Hernán
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source