Results 41 to 50 of about 194,483 (282)
International Journal of Infectious Diseases, 2022 Objectives: This study aim to evaluate the effectiveness of fluoroquinolone (FQ) antimicrobial therapy in combination with tetracyclines (TCs) in patients with Japanese spotted fever (JSF) using a nationwide inpatient database in Japan.Methods: We ...
Satoshi Kutsuna +3 more
doaj +1 more source
Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study
Trials, 2019 Background Randomized trials are considered the gold standard for making inferences about the causal effects of treatments. However, when protocol deviations occur, the baseline randomization of the trial is no longer sufficient to ensure unbiased ...
Jessica G. Young +3 more
doaj +1 more source
Adjusting for Confounding in Early Postlaunch Settings: Going beyond Logistic Regression Models [PDF]
, 2016 Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Background: Postlaunch data on medical treatments can be analyzed to explore adverse events or relative effectiveness in real-life settings.
Groenwold, RHH, Klungel, OH, Schmidt, AF
core +1 more source
A note on overadjustment in inverse probability weighted estimation [PDF]
Biometrika, 2010 Standardized means, commonly used in observational studies in epidemiology to adjust for potential confounders, are equal to inverse probability weighted means with inverse weights equal to the empirical propensity scores. More refined standardization corresponds with empirical propensity scores computed under more flexible models.
Andrea Rotnitzky +2 more
openaire +3 more sources
Sensitivity analysis for causal inference using inverse probability weighting [PDF]
Biometrical Journal, 2011 AbstractEvaluation of impact of potential uncontrolled confounding is an important component for causal inference based on observational studies. In this article, we introduce a general framework of sensitivity analysis that is based on inverse probability weighting.
Shen, Changyu +3 more
openaire +2 more sources
Frontiers in Aging Neuroscience, 2023 BackgroundThe relationship between statin use and delirium remains controversial; therefore, we aimed to study the association between statin exposure and delirium and in-hospital mortality in patients with congestive heart failure.MethodsIn this ...
Jiangling Xia +3 more
doaj +1 more source
Discontinuous Parameter Estimates with Least Squares Estimators [PDF]
, 2013 We discuss weighted least squares estimates of ill-conditioned linear inverse problems where weights are chosen to be inverse error covariance matrices.
Mead, J. L.
core +2 more sources
Inverse Probability Weights for the Analysis of Polytomous Outcomes [PDF]
American Journal of Epidemiology, 2018 Polytomous outcomes are common in epidemiologic studies. Analyses based on multinomial models employ a likelihood that utilizes the data observed in all outcome categories simultaneously and permits inferences regarding associations across outcome categories.
David B, Richardson +5 more
openaire +2 more sources
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source