Results 51 to 60 of about 1,742,420 (301)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Prediction-Powered Inference with Inverse Probability Weighting

CoRR
Prediction-powered inference (PPI) is a recent framework for valid statistical inference with partially labeled data, combining model-based predictions on a large unlabeled set with bias correction from a smaller labeled subset. Building on existing PPI results under covariate shift, we show that PPI rectification admits a direct design-based ...
Jyotishka Datta, Nicholas G. Polson
openaire   +2 more sources

Inverse Probability Weighted Cox Regression for Doubly Truncated Data [PDF]

Biometrics, 2017
SummaryDoubly truncated data arise when event times are observed only if they fall within subject-specific, possibly random, intervals. While non-parametric methods for survivor function estimation using doubly truncated data have been intensively studied, only a few methods for fitting regression models have been suggested, and only for a limited ...
Micha Mandel, Jacobo de Uña-Álvarez, David K. Simon, Rebecca A. Betensky   +3 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Standardized differences to identify imbalances between treatment groups before and after imputing and inverse-probability-of-treatment-weighting.

, 2016
Standardized differences to identify imbalances between treatment groups before and after imputing and inverse-probability-of-treatment-weighting.
Anna Suling (759811), Petra Neuser (3324771), Alexander Reuss (3324780), Ulrich Canzler (3324768), Christine Eulenburg (3324777), Linn Woelber (664221), Alexander Luyten (746646), Tanja Fehm (23618), Martin Hellriegel (3324774), Sven Mahner (664222)   +9 more
core   +1 more source

Demystifying stabilization in inverse probability of treatment weighting

Journal of Biopharmaceutical Statistics
Inverse probability of treatment weighting (IPTW) is a common approach to infer causal treatment effects when covariates are imbalanced at baseline or over time among treatment groups. One limitation of the IPTW is that a few observations with large weights can disproportionately influence inference, leading to dramatically increased variability in ...
Yong, Ma, Andrew, Giffin, Jiwei, He, Hana, Lee   +3 more
openaire   +2 more sources

The Kaplan–Meier Estimator as an Inverse-Probability-of-Censoring Weighted Average [PDF]

The American Statistician, 2001
The Kaplan-Meier (product-limit) estimator of the survival function of randomly-censored time-to-event data is a central quantity in survival analysis. It is usually introduced as a nonparametric maximum likelihood estimator, or else as the output of an imputation scheme for censored observations such as redistribute-to-the-right or self-consistency ...
Satten G. A., Datta S.
openaire   +3 more sources

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Efficacy and Safety of Antiplatelet Therapy After Endovascular Aortic Repair: A Target Trial Emulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The optimal antiplatelet regimen after standard endovascular aneurysm repair (EVAR) in patients without atherosclerotic cardiovascular disease remains uncertain.
Ki Hong Choi, Danbee Kang, Jihee Nam, Take Kyu Park, Myung Gyu Song, Tae‐Seok Seo, Woo Jin Yang, Seung‐Hyuk Choi   +7 more
doaj   +1 more source