Results 261 to 270 of about 948,947 (298)
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Pflügers Archiv - European Journal of Physiology, 2011
Most physical illness in vertebrates involves inflammation. Inflammation causes disease by fluid shifts across cell membranes and cell layers, changes in muscle function and generation of pain. These disease processes can be explained by changes in numbers or function of ion channels.
Michael, Eisenhut, Helen, Wallace
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Most physical illness in vertebrates involves inflammation. Inflammation causes disease by fluid shifts across cell membranes and cell layers, changes in muscle function and generation of pain. These disease processes can be explained by changes in numbers or function of ion channels.
Michael, Eisenhut, Helen, Wallace
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Annual Review of Physiology, 1984
It may be reasonably argued that of all classes of known cellular proteins, the ion channels are the least understood biochemically. Of the large number of channel proteins known from cellular electrical behavior to exist in the mem branes of higher organisms, only three-the nicotinic acetylcholine receptor, the Na+ channel, and the mitochondrial ...
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It may be reasonably argued that of all classes of known cellular proteins, the ion channels are the least understood biochemically. Of the large number of channel proteins known from cellular electrical behavior to exist in the mem branes of higher organisms, only three-the nicotinic acetylcholine receptor, the Na+ channel, and the mitochondrial ...
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Annals of the New York Academy of Sciences, 2002
Abstract:In this section eight presenters focus on three distinct aspects of chromaffin cell biology: first, the properties of neuronal nicotinic receptors; second, the shaping of the Ca2+signals that underlie chromaffin cell function; and third, the properties and expression of cell surface transporter proteins.
Powis, David A., Marley, Philip D.
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Abstract:In this section eight presenters focus on three distinct aspects of chromaffin cell biology: first, the properties of neuronal nicotinic receptors; second, the shaping of the Ca2+signals that underlie chromaffin cell function; and third, the properties and expression of cell surface transporter proteins.
Powis, David A., Marley, Philip D.
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Physical Review Letters, 1990
A relativistic electron beam propagating through a plasma in the ion-focused regime exhibits an electromagnetic instability with peak growth rate near a resonant frequency {omega}{similar to}2{gamma}{sup 2}{omega}{sub {beta}}. Growth is enhanced by optical guiding in the ion channel, which acts as a dielectric waveguide, with fiber parameter {ital V ...
, Whittum, , Sessler, , Dawson
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A relativistic electron beam propagating through a plasma in the ion-focused regime exhibits an electromagnetic instability with peak growth rate near a resonant frequency {omega}{similar to}2{gamma}{sup 2}{omega}{sub {beta}}. Growth is enhanced by optical guiding in the ion channel, which acts as a dielectric waveguide, with fiber parameter {ital V ...
, Whittum, , Sessler, , Dawson
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Phosphorylation of Ion channels
The Journal of Membrane Biology, 1985The introduction of highly specific reagents such as enzymes and inhibitors directly into living cells has proven to be a powerful tool in studying the modulation of cellular activity by protein phosphorylation. The use of exogenous kinases can be thought of as a pharmacological approach: this demonstrates that phosphorylation can produce modulation ...
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Journal of Applied Toxicology, 2010
AbstractIon channels play essential roles in human physiology and toxicology. Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role.
Iván, Restrepo-Angulo +2 more
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AbstractIon channels play essential roles in human physiology and toxicology. Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role.
Iván, Restrepo-Angulo +2 more
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Science, 1997
A brief touch can trigger immediate flight in an animal. In his Perspective, Grillner discusses a finding reported on page 1122 of this issue by Viana di Prisco et al . that may underlie this response. Transient stimulation on the skin of a lamprey causes a long-lasting excitation of the neurons that control motor behaviors, initiating ...
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A brief touch can trigger immediate flight in an animal. In his Perspective, Grillner discusses a finding reported on page 1122 of this issue by Viana di Prisco et al . that may underlie this response. Transient stimulation on the skin of a lamprey causes a long-lasting excitation of the neurons that control motor behaviors, initiating ...
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Current Pharmaceutical Design, 2005
The role of voltage-gated and ligand-gated ion channels in epileptogenesis of both genetic and acquired epilepsies, and as targets in the development of new antiepileptic drugs (AEDs) is reviewed. Voltage-gated Na+ channels are essential for action potentials, and their mutations are the substrate for generalised epilepsy with febrile seizures plus and
J A, Armijo +5 more
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The role of voltage-gated and ligand-gated ion channels in epileptogenesis of both genetic and acquired epilepsies, and as targets in the development of new antiepileptic drugs (AEDs) is reviewed. Voltage-gated Na+ channels are essential for action potentials, and their mutations are the substrate for generalised epilepsy with febrile seizures plus and
J A, Armijo +5 more
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Trends in Neurosciences, 1995
Transmembrane ion channels regulate the movement of ions (particularly Na+, K+, Ca2+ and Cl-) across cellular membranes, and are critical to numerous aspects of neurobiology. Cells express a diverse array of ion-channel proteins that vary widely in their ion selectivity and in their modulation by ligands (such as neurotransmitters) or by membrane ...
W N, Green, N S, Millar
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Transmembrane ion channels regulate the movement of ions (particularly Na+, K+, Ca2+ and Cl-) across cellular membranes, and are critical to numerous aspects of neurobiology. Cells express a diverse array of ion-channel proteins that vary widely in their ion selectivity and in their modulation by ligands (such as neurotransmitters) or by membrane ...
W N, Green, N S, Millar
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Current Opinion in Pediatrics, 2001
Diseases as different as cardiac arrhythmias, epilepsy, myotonia, malignant hyperthermia, familial hyperinsulinism, and Bartter syndrome have all been linked to mutations in genes encoding ion channels. This has been made possible by an exciting and fruitful collaboration between clinicians, geneticists, and physiologists. It has led to a more detailed
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Diseases as different as cardiac arrhythmias, epilepsy, myotonia, malignant hyperthermia, familial hyperinsulinism, and Bartter syndrome have all been linked to mutations in genes encoding ion channels. This has been made possible by an exciting and fruitful collaboration between clinicians, geneticists, and physiologists. It has led to a more detailed
openaire +2 more sources