Results 251 to 260 of about 948,947 (298)
Exploring Ion Channel Magnetic Pharmacology: Are Magnetic Cues a Viable Alternative to Ion Channel Drugs? [PDF]
BioessaysZablotskii V, Polyakova T, Dejneka A.
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Deciphering gain-of-function from loss-of-function variants with AlphaMissense: A case study with the mechanosensitive PIEZO1 ion channel protein. [PDF]
Biochem Biophys RepPillai J +4 more
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Robustness through variability: ion channel isoform diversity safeguards neuronal excitability
Hilgert S +8 more
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Biochemistry, 2003
Fifteen years ago the presence of ion channels in the cytoplasmic membrane of bacteria was held by many to be inherently unlikely, given the prominent role played by the membrane in energy transduction. The presence of channels in the outer membrane of Gram negative bacteria was known and the physiological roles, structures and genetics were already ...
Ian R, Booth +2 more
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Fifteen years ago the presence of ion channels in the cytoplasmic membrane of bacteria was held by many to be inherently unlikely, given the prominent role played by the membrane in energy transduction. The presence of channels in the outer membrane of Gram negative bacteria was known and the physiological roles, structures and genetics were already ...
Ian R, Booth +2 more
openaire +4 more sources
Annual Review of Physiology, 2002
▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered propagation of excitatory stimuli that result in rapid depolarization and slow repolarization, thereby generating action potentials in individual myocytes. Abnormalities of impulse generation, propagation, or the duration and configuration of individual cardiac ...
Dan M, Roden +3 more
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▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered propagation of excitatory stimuli that result in rapid depolarization and slow repolarization, thereby generating action potentials in individual myocytes. Abnormalities of impulse generation, propagation, or the duration and configuration of individual cardiac ...
Dan M, Roden +3 more
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2010
Ion channels are integral membrane proteins that contain pathways through which ions can flow. By shifting between closed and open conformational states ('gating' process), they control passive ion flow through the plasma membrane. Channels can be gated by membrane potential, or specific ligands, or other agents, such as mechanical stimuli.
DI RESTA, CHIARA, BECCHETTI, ANDREA
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Ion channels are integral membrane proteins that contain pathways through which ions can flow. By shifting between closed and open conformational states ('gating' process), they control passive ion flow through the plasma membrane. Channels can be gated by membrane potential, or specific ligands, or other agents, such as mechanical stimuli.
DI RESTA, CHIARA, BECCHETTI, ANDREA
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Critical Reviews in Biochemistry, 1985
The first model of the structure of cell membranes was developed very early from indirect evidence.' It postulated the existence of a bimolecular lipid membrane which serves as the main and electrical isolating part of the cell membrane. The proteins were either associated with or incorporated into the membrane.Z Following this idea, it was postulated ...
Wolfang Hanke, Christopher Miller
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The first model of the structure of cell membranes was developed very early from indirect evidence.' It postulated the existence of a bimolecular lipid membrane which serves as the main and electrical isolating part of the cell membrane. The proteins were either associated with or incorporated into the membrane.Z Following this idea, it was postulated ...
Wolfang Hanke, Christopher Miller
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Science Signaling, 2001
The functions of ion channels can be regulated by their phosphorylation state. Protein kinases and protein phosphatases tightly control the activity of channels, thereby regulating the flow of ions across cell membranes. Channel proteins and kinases or phosphatases can associate directly or through intermediate adaptor proteins.
S N, MacFarlane, I B, Levitan
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The functions of ion channels can be regulated by their phosphorylation state. Protein kinases and protein phosphatases tightly control the activity of channels, thereby regulating the flow of ions across cell membranes. Channel proteins and kinases or phosphatases can associate directly or through intermediate adaptor proteins.
S N, MacFarlane, I B, Levitan
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2021
Ion channels play a pivotal role in anesthesia, including general and regional anesthesia. Two main classes of general anesthetics (GAs) are inhalational anesthetics, such as isoflurane, sevoflurane, and nitrous oxide; injectable anesthetics, such as propofol, etomidate, and ketamine. Besides hypnotic agents, muscle relaxants for immobility and opioids
Wei, Zhou, Zhonghui, Guan
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Ion channels play a pivotal role in anesthesia, including general and regional anesthesia. Two main classes of general anesthetics (GAs) are inhalational anesthetics, such as isoflurane, sevoflurane, and nitrous oxide; injectable anesthetics, such as propofol, etomidate, and ketamine. Besides hypnotic agents, muscle relaxants for immobility and opioids
Wei, Zhou, Zhonghui, Guan
openaire +2 more sources