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Electrostatic tuning of Na<sub>V</sub> channel activation by the domain II S3-S4 extracellular loop. [PDF]
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Electromagnetic gating in ion channels
Journal of Theoretical Biology, 1992There have been many attempts to develop a theoretical explanation of the phenomena of electromagnetic field interactions with biological systems. None of the reported efforts have been entirely successful in accounting for the observed experimental results, in particular with respect to the reports of interactions between extremely low frequency (ELF)
B R, McLeod, A R, Liboff, S D, Smith
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Angewandte Chemie International Edition, 2001
Ion channels are at the heart of many biological processes such as nerve activity and muscle contraction. How are their impressive ion selectivity and highly specialized gating brought about? In recent years, X-ray crystallography and high-resolution electron microscopy, as well as photo-affinity labeling and site-specific mutagenesis techniques in ...
Ferdinand, Hucho, Christoph, Weise
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Ion channels are at the heart of many biological processes such as nerve activity and muscle contraction. How are their impressive ion selectivity and highly specialized gating brought about? In recent years, X-ray crystallography and high-resolution electron microscopy, as well as photo-affinity labeling and site-specific mutagenesis techniques in ...
Ferdinand, Hucho, Christoph, Weise
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Ion channel gating: insights via molecular simulations [PDF]
FEBS Letters, 2003 Ion channels are gated, i.e. they can switch conformation between a closed and an open state. Molecular dynamics simulations may be used to study the conformational dynamics of ion channels and of simple channel models.
Philip C. Biggin +2 more
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Palladium(ii)-gated ion channels
Chemical Communications, 2008A simple ion channel has been developed that can be created or disassembled through the addition or removal of palladium(II).
Wilson, Craig P. +1 more
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Ligand‐Gated Synthetic Ion Channels
Chemistry – A European Journal, 2005AbstractSupramolecular π‐stack architecture is fundamental in DNA chemistry but absent in biological and synthetic ion channels and pores. Here, a novel rigid‐rod π‐stack architecture is introduced to create synthetic ion channels with characteristics that are at the forefront of rational design, that is, ligand gating by a conformational change of the
Talukdar, Pinaki +4 more
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Voltage gating of ion channels
Quarterly Reviews of Biophysics, 1994Voltage-gated ion channels are membrane proteins that play a central role in the propagation and transduction of cellular signals (Hille, 1992). Calcium ions entering cells through voltage-gated calcium channels serve as the trigger for neurotransmitter release, muscle contraction, and the release of hormones. Voltage-gated sodium channels initiate the
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Metal ion effects on ion channel gating
Quarterly Reviews of Biophysics, 20031. Introduction 3742. Metals in biology 3783. The targets: structure and function of ion channels 3804. General effects of metal ions on channels 3824.1 Three types of general effect 3824.2 The main regulators 3835. Effects on gating: mechanisms and models 3845.1 Screening surface charges (Mechanism A) 3875.1.1 The classical approach 3875.1.1.1 ...
Fredrik, Elinder, Peter, Arhem
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2021
Abstract Excitable cells, such as neurons and muscles, use ion channels to generate electrical and chemical signals that underlie their functions. Examples include the electrical signals underlying the complex neuronal circuitry in the brain, the secretion of hormones and neurotransmitters, skeletal and cardiac muscle contraction, and ...
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Abstract Excitable cells, such as neurons and muscles, use ion channels to generate electrical and chemical signals that underlie their functions. Examples include the electrical signals underlying the complex neuronal circuitry in the brain, the secretion of hormones and neurotransmitters, skeletal and cardiac muscle contraction, and ...
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A model of the gating of ion channels
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1988The gating of ion channels in biological membranes has usually been described in terms of Markov transitions between a few discrete open or closed states. Such models predict that the distributions of open and closed durations decay as a sum of exponential terms.
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