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Ion Channels: Opening the Gate
Science, 1996A recent paper in Science ( 12 Jan., p. 213 ) and two papers in Neuron (H. P. Larsson et al. , in press, and N. Yang et al. , vol. 16, p. 113) demonstrate that a charged portion of the sodium and potassium ion channel (S4)
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A Light-Gated Synthetic Ion Channel
Organic Letters, 2008A gated synthetic ion channel with beta-cyclodextrin as the pore and azobenzene as the gate is reported. Irradiation converts a tethered trans-azobenzene to cis-azobenzene which likely transforms the channel from a self-inclusion complex to a dissociated structure.
Parag V, Jog, Mary S, Gin
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2008
How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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Are Ions Involved in the Gating of Calcium Channels?
Science, 1982The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current ...
Y, Saimi, C, Kung
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The voltage sensor and the gate in ion channels
2003Publisher Summary This chapter illustrates two aspects of ion channels: the gating process and the transduction from the initiating stimulus to the operation of the gate. The gating process is the operation of the gate proper while the transducer may be considered the sensor of the stimulus that ultimately opens and closes the channel.
Francisco, Bezanilla, Eduardo, Perozo
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On the opening of voltage-gated ion channels
Physiology & Behavior, 2007Voltage-gated ion channels are key players in fast neuronal signalling. Detailed knowledge about channel gating is essential for our understanding of channel function in general and of drug action of channels in particular. Despite a number of recent atomic channel structures, the opening of voltage-gated channels is the subject of heated debates. Here
Fredrik, Elinder +2 more
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Cyclic Nucleotide-Gated Ion Channels
Annual Review of Cell and Developmental Biology, 2003▪ Abstract  Cyclic nucleotide-gated (CNG) ion channels were first discovered in rod photoreceptors, where they are responsible for the primary electrical signal of the photoreceptor in response to light. CNG channels are highly specialized membrane proteins that open an ion-permeable pore across the membrane in response to the direct binding of ...
Kimberly, Matulef, William N, Zagotta
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The kinetics of voltage-gated ion channels
Quarterly Reviews of Biophysics, 1994When Hodgkin & Huxley (1952) first embarked on the analysis of their voltageclamp data on the ionic currents in the squid giant axon, they hoped to be able to deduce a mechanism from it, but it soon became clear that the electrical data would by themselves yield only very general information about the class of system likely to be involved.
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Voltage Gated Ion Channels and Sleep
The Journal of Membrane BiologyIon channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or localization, can lead to irregular neuronal excitability and synaptic communication, which may manifest as various ...
Yan, Zhang +5 more
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Molecular mechanisms of gated ion channels
Bioelectrochemistry and Bioenergetics, 1986Abstract Ion channels form the basis for intercellular communication in biological systems. With the advent of cloning techniques, it is now possible to sequence the proteins that form such channels. The acetylcholine receptor, for example, which consists of five subunits, and the voltage gated sodium channel have been completely sequenced by Noda et
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