Results 101 to 110 of about 2,488,331 (299)

Configuration‐Encoded Cell Alignment by Light‐Gated Silicon Photovoltaic Microcell Arrays

Advanced Functional Materials, EarlyView.
Light‐gated silicon photovoltaic microcells convert pulsed illumination into localized electrical cues. Arranging otherwise similar microcells into four‐lobed, six‐lobed, or circular patterns directs fibroblasts into corresponding local arrangements without wired stimulation.
Yifan Tao, Ilayda Namli, Joseph Christakiran Moses, Youdi Liu, Suihong Liu, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Ibrahim T. Ozbolat   +7 more
wiley   +1 more source

The Hydrophobic Effect Contributes to the Closed State of a Simplified Ion Channel through a Conserved Hydrophobic Patch at the Pore-Helix Crossing.

Frontiers in Pharmacology, 2015
Ion selectivity-filter structures are strikingly similar throughout the large family of K+ channels and other p-loop-like receptors (i.e., glutamate receptors). At the same time, the triggers for opening these channels, or gating, are diverse.
Michael eYonkunas, Maria eKurnikova
doaj   +1 more source

The RyR1 P3528S Substitution Alters Mouse Skeletal Muscle Contractile Properties and RyR1 Ion Channel Gating. [PDF]

Int J Mol Sci, 2023
Thekkedam CG, Dutka TL, Van der Poel C, Burgio G, Dulhunty AF.   +4 more
europepmc   +1 more source

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Molecular architecture of the fungal-specific potassium channel TOK1

Nature Communications
In Candida albicans, potassium (K+) channels fine-tune ionic balance under stress, contributing to host colonization. Fungal two-pore domain, outwardly rectifying potassium (TOK) channels remain insufficiently characterized despite evidence implicating ...
Brice Durocher, Rían W. Manville, Rui Yan, Zhiheng Yu, Geoffrey W. Abbott, Alexandria N. Miller   +5 more
doaj   +1 more source

Similarity of the ion occupations of K+ and Tl+ in the selectivity filter of a K+ channel, as verified by single-channel currents

Channels
Voltage-dependent gating in the selectivity filter of potassium channels is modulated by the permeating ions binding within the filter. In the viral Kcv channel, filter gating occurs on the sub-millisecond time scale.
Lena Diederich, Jessica Múnera-Jaramillo, Ulf-Peter Hansen, Indra Schroeder   +3 more
doaj   +1 more source

Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating. [PDF]

Phys Med Biol, 2023
Choi H, Iyer RR, Renteria CA, Boppart SA.   +3 more
europepmc   +1 more source

Programming Neuromorphic Plasticity Through Ionic and Electronic Coupling in Organic Electrochemical Transistors

Advanced Functional Materials, EarlyView.
Neuromorphic plasticity in OECTs is governed by the post‐stimulus evolution of coupled ionic and electronic states. Semiconductor chemistry and morphology, electrolyte composition and interfaces, and device architecture regulate ion injection, transport, confinement, and release, shifting responses from rapidly relaxing STP to metastable memory and ...
Inho Lee, Hyoik Jang, Ji Hwan Kim, Jonghyun Won, Namhee Kim, Wonseok Shin, Giwon Lee, Eunho Lee, Daegun Kim, Sungjun Park   +9 more
wiley   +1 more source

2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. [PDF]

Biophys J, 2023
Oikonomou E, Gruber T, Chandra AR, Höller S, Alzheimer C, Wellein G, Huth T.   +6 more
europepmc   +1 more source

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6 [PDF]

, 2012
Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating.
Mano Sitsapesan (182017), Tsaneva-Atanasova, Krasimira, Samantha J Pitt, Pitt Samantha J., Zaccai, N, Krasimira Tsaneva-Atanasova (144624), Sitsapesan, Rebecca, Tsaneva-Atanasova, KT, Pitt, SJ, Stephen O'Neill (182027), Zaccai Nathan R., Tsaneva-Atanasova Krasimira, Sitsapesan Rebecca, O'Neill Stephen, Galfre, Elena, Pitt, Samantha Jane, Nathan R. Zaccai (182021), Venturi Elisa, Sitsapesan, Mano, Mano Sitsapesan, Galfré Elena, Rebecca Sitsapesan (182033), Sitsapesan Mano, Rebecca Sitsapesan, Venturi, E, Samantha J. Pitt (182004), Stephen O'Neill, Elisa Venturi, Elena Galfré, Elena Galfré (182000), Elisa Venturi (182009), O'Neill, Stephen, Nathan R Zaccai, Sitsapesan, R, O'Neill, S, Krasimira Tsaneva-Atanasova, Venturi, Elisa, Zaccai, Nathan R, Sitsapesan, M, Pitt, Samantha Jane; id_orcid, Galfre, E   +40 more
core   +1 more source