Results 41 to 50 of about 57,056 (243)

The role of conformational diffusion in ion channel gating

, 2003
We consider an exactly tractable model of the Kramers type for the voltage-dependent gating dynamics of single ion channels. It is assumed that the gating dynamics is caused by the thermally activated transitions in a bistable potential.
Bezanilla, Blatz, Bässler, Colquhoun, Condat, de Gennes, Dobson, Frauenfelder, Frauenfelder, Goychuk, Hille, Hodgkin, Hänggi, Igor Goychuk, Jiang, Liebovitch, Läuger, Mainen, Mercik, Metzler, Millhauser, Moore, Peter Hänggi, Ring, Rodriguez, Salman, Sansom, Sigg, Yellen   +28 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Voltage-dependent gating in a "voltage sensor-less" ion channel.

PLoS Biology, 2010
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata, Markus Rapedius, Marc J Kleinman, Thomas Baukrowitz, Colin G Nichols   +4 more
doaj   +1 more source

Comparison of Langevin and Markov channel noise models for neuronal signal generation

, 2009
The stochastic opening and closing of voltage-gated ion channels produces noise in neurons. The effect of this noise on the neuronal performance has been modelled using either approximate or Langevin model, based on stochastic differential equations or ...
A. L. Hodgkin, B. Sengupta, C. P. Fall, C. W. Gardiner, E. M. Izhikevich, F. Rieke, G. Marsaglia, J. C. Roddey, J. E. McGeoch, J. E. Niven, J. S. Bendat, P. E. Kloeden, S. B. Laughlin, T. M. Cover, W. Gerstner, W. H. Press   +15 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits [PDF]

, 2015
The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action.
Allgaier, Alvestad, Anders, Anders, Boyce-Rustay, Chandrasekar, Chu, Dingledine, Donard S. Dwyer, Dopico, Dwyer, Erreger, Gass, Gonzales, Göthert, Hoffman, Holmes, Hong Ren, Honse, Izumi, Karakas, Kash, Kash, Kash, Koob, Krishnan-Sarin, Krupitsky, Krystal, Kuner, Lima-Landman, Lovinger, Low, Low, Masood, Mihic, Moykkynen, Nagy, Peoples, Peoples, Peoples, Popp, Ren, Ren, Ren, Ren, Ren, Ren, Robert W. Peoples, Ronald, Salous, Smothers, Smothers, Smothers, Sobolevsky, Sobolevsky, Vengeliene, Vengeliene, Wang, Weiss, Wick, Wills, Woodward, Woodward, Wright, Xu, Xu, Yamakura, Yuan, Yulin Zhao   +68 more
core   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

eLife, 2019
Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here, we present
David M Kern, SeCheol Oh, Richard K Hite, Stephen G Brohawn   +3 more
doaj   +1 more source

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics. [PDF]

PLoS Computational Biology, 2017
Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response to the binding of a neurotransmitter. Despite the increasing availability of high-resolution structures of pLGICs,
Nicolas E Martin, Siddharth Malik, Nicolas Calimet, Jean-Pierre Changeux, Marco Cecchini   +4 more
doaj   +1 more source