Results 231 to 240 of about 276,631 (268)
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Critical Reviews in Biochemistry, 1985
The first model of the structure of cell membranes was developed very early from indirect evidence.' It postulated the existence of a bimolecular lipid membrane which serves as the main and electrical isolating part of the cell membrane. The proteins were either associated with or incorporated into the membrane.Z Following this idea, it was postulated ...
Wolfang Hanke, Christopher Miller
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The first model of the structure of cell membranes was developed very early from indirect evidence.' It postulated the existence of a bimolecular lipid membrane which serves as the main and electrical isolating part of the cell membrane. The proteins were either associated with or incorporated into the membrane.Z Following this idea, it was postulated ...
Wolfang Hanke, Christopher Miller
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Science Signaling, 2001
The functions of ion channels can be regulated by their phosphorylation state. Protein kinases and protein phosphatases tightly control the activity of channels, thereby regulating the flow of ions across cell membranes. Channel proteins and kinases or phosphatases can associate directly or through intermediate adaptor proteins.
S N, MacFarlane, I B, Levitan
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The functions of ion channels can be regulated by their phosphorylation state. Protein kinases and protein phosphatases tightly control the activity of channels, thereby regulating the flow of ions across cell membranes. Channel proteins and kinases or phosphatases can associate directly or through intermediate adaptor proteins.
S N, MacFarlane, I B, Levitan
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Pflügers Archiv - European Journal of Physiology, 2011
Most physical illness in vertebrates involves inflammation. Inflammation causes disease by fluid shifts across cell membranes and cell layers, changes in muscle function and generation of pain. These disease processes can be explained by changes in numbers or function of ion channels.
Michael, Eisenhut, Helen, Wallace
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Most physical illness in vertebrates involves inflammation. Inflammation causes disease by fluid shifts across cell membranes and cell layers, changes in muscle function and generation of pain. These disease processes can be explained by changes in numbers or function of ion channels.
Michael, Eisenhut, Helen, Wallace
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2019
Since its discovery, aldosterone and ion modulation have been entwined. While scientific investigations throughout the decades have emphasized aldosterone's connection to Na+, K+, and H+ homeostasis, more recent research has demonstrated a relationship between aldosterone and Mg2+, Ca2+, and Cl- homeostasis. The mechanisms connecting aldosterone to ion
William C, Valinsky +2 more
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Since its discovery, aldosterone and ion modulation have been entwined. While scientific investigations throughout the decades have emphasized aldosterone's connection to Na+, K+, and H+ homeostasis, more recent research has demonstrated a relationship between aldosterone and Mg2+, Ca2+, and Cl- homeostasis. The mechanisms connecting aldosterone to ion
William C, Valinsky +2 more
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Current Opinion in Pediatrics, 2001
Diseases as different as cardiac arrhythmias, epilepsy, myotonia, malignant hyperthermia, familial hyperinsulinism, and Bartter syndrome have all been linked to mutations in genes encoding ion channels. This has been made possible by an exciting and fruitful collaboration between clinicians, geneticists, and physiologists. It has led to a more detailed
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Diseases as different as cardiac arrhythmias, epilepsy, myotonia, malignant hyperthermia, familial hyperinsulinism, and Bartter syndrome have all been linked to mutations in genes encoding ion channels. This has been made possible by an exciting and fruitful collaboration between clinicians, geneticists, and physiologists. It has led to a more detailed
openaire +2 more sources
Current Pharmaceutical Design, 2005
The role of voltage-gated and ligand-gated ion channels in epileptogenesis of both genetic and acquired epilepsies, and as targets in the development of new antiepileptic drugs (AEDs) is reviewed. Voltage-gated Na+ channels are essential for action potentials, and their mutations are the substrate for generalised epilepsy with febrile seizures plus and
J A, Armijo +5 more
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The role of voltage-gated and ligand-gated ion channels in epileptogenesis of both genetic and acquired epilepsies, and as targets in the development of new antiepileptic drugs (AEDs) is reviewed. Voltage-gated Na+ channels are essential for action potentials, and their mutations are the substrate for generalised epilepsy with febrile seizures plus and
J A, Armijo +5 more
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Trends in Neurosciences, 1995
Transmembrane ion channels regulate the movement of ions (particularly Na+, K+, Ca2+ and Cl-) across cellular membranes, and are critical to numerous aspects of neurobiology. Cells express a diverse array of ion-channel proteins that vary widely in their ion selectivity and in their modulation by ligands (such as neurotransmitters) or by membrane ...
W N, Green, N S, Millar
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Transmembrane ion channels regulate the movement of ions (particularly Na+, K+, Ca2+ and Cl-) across cellular membranes, and are critical to numerous aspects of neurobiology. Cells express a diverse array of ion-channel proteins that vary widely in their ion selectivity and in their modulation by ligands (such as neurotransmitters) or by membrane ...
W N, Green, N S, Millar
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EcoSal Plus, 2010
Bacterial ion channels were known, but only in special cases, such as outer membrane porins in Escherichia coli and bacterial toxins that form pores in their target (bacterial or mammalian) membranes. The exhaustive coverage provided by a decade of bacterial genome sequencing has revealed that ion channels are ...
Emma L R, Compton, Joseph A, Mindell
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Bacterial ion channels were known, but only in special cases, such as outer membrane porins in Escherichia coli and bacterial toxins that form pores in their target (bacterial or mammalian) membranes. The exhaustive coverage provided by a decade of bacterial genome sequencing has revealed that ion channels are ...
Emma L R, Compton, Joseph A, Mindell
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Phosphorylation of Ion channels
The Journal of Membrane Biology, 1985The introduction of highly specific reagents such as enzymes and inhibitors directly into living cells has proven to be a powerful tool in studying the modulation of cellular activity by protein phosphorylation. The use of exogenous kinases can be thought of as a pharmacological approach: this demonstrates that phosphorylation can produce modulation ...
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Science, 1986
Voltage-dependent ion channels have been found in the plasma membrane of the yeast Saccharomyces cerevisiae . Ion channel activities were recorded from spheroplasts or patches of plasma membrane with the patch-clamp technique. The most prominent activities came from a set of potassium channels with the properties of
M C, Gustin +4 more
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Voltage-dependent ion channels have been found in the plasma membrane of the yeast Saccharomyces cerevisiae . Ion channel activities were recorded from spheroplasts or patches of plasma membrane with the patch-clamp technique. The most prominent activities came from a set of potassium channels with the properties of
M C, Gustin +4 more
openaire +2 more sources