Results 41 to 50 of about 904,732 (368)
Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium. [PDF]
, 2015 The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and ...
Choi, Jae Young +8 more
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Ion channels and ion selectivity [PDF]
Essays in Biochemistry, 2017 Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential.
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Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current
ChannelsL-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia +5 more
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Label-free optical imaging of ion channel activity on living cells [PDF]
arXiv, 2023 Deciphering ion channel activity and signaling interactions within cells is one of the key tasks of neuroscience. Currently, measuring this electrophysiological activity is done using patch-clamp1-4 or voltage-sensitive imaging5-8. Unfortunately, these techniques are unable to balance between single-channel sensitivity and highthroughput detection ...
arxiv
Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family [PDF]
, 2013 We use Brownian dynamics (BD) simulations to study the ionic conduction and valence selectivity of a generic electrostatic model of a biological ion channel as functions of the fixed charge Qf at its selectivity filter.
Eisenberg, Robert S. +4 more
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Mitochondrial Ion Channels [PDF]
Annual Review of Physiology, 2007 In work spanning more than a century, mitochondria have been recognized for their multifunctional roles in metabolism, energy transduction, ion transport, inheritance, signaling, and cell death. Foremost among these tasks is the continuous production of ATP through oxidative phosphorylation, which requires a large electrochemical driving force for ...
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Simulation and calculation of the contribution of hyperpolarization-activated cyclic nucleotide-gated channels to action potentials [PDF]
Archives of Biological Sciences, 2016 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, which mediates the influx of cations, has an important role in action potential generation.
Liao Liping +6 more
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Frontiers in Oncology, 2022 A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of ...
Brigitte Pelzmann +19 more
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Scentsational Ion Channels [PDF]
Neuron, 1996 Finally, but perhaps most enticing, Coburn and Bargmann also observed striking defects in the growth of sensory axons in tax-2 and tax-4 mutants. The defects were primarily expressed as an overgrowth of axonal processes, with subsets of sensory neurons displaying either inappropriate additional axonal branches or a failure to terminate upon reaching ...
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TRPM Family Channels in Cancer
Pharmaceuticals, 2018 Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains.
Aline Hantute-Ghesquier +3 more
doaj +1 more source