Results 41 to 50 of about 4,654,285 (364)
Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current
ChannelsL-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia +5 more
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TRPM8 Puts the Chill on Prostate Cancer
Pharmaceuticals, 2016 Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed countries. Several studies suggest that variations in calcium homeostasis are involved in carcinogenesis. Interestingly, (Transient Receptor Potential Melastatin member 8)
Guillaume P. Grolez, Dimitra Gkika
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Nature Communications, 2022 Photoactivable toxins targeting ion channels have great potential to control cell activity. Here the authors report HwTxIV-Nvoc, a UV light-cleavable and photoactivatable peptide that targets voltage-gated sodium channels; they validate this in cells ...
Jérôme Montnach +15 more
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, 1990 A relativistic electron beam propagating through a plasma in the ion-focused regime exhibits an electromagnetic instability at a resonant frequency {omega} {approximately} 2{gamma}{sup 2} {omega}{sub {beta}}. Growth is enhanced by optical guiding in the ion channel, which acts as dielectric waveguide, with fiber parameter V {approximately} 2 (I/I{sub A}
Whittum, D H, Sessler, A M, Dawson, J M
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Mitochondrial Ion Channels [PDF]
Annual Review of Physiology, 2007 In work spanning more than a century, mitochondria have been recognized for their multifunctional roles in metabolism, energy transduction, ion transport, inheritance, signaling, and cell death. Foremost among these tasks is the continuous production of ATP through oxidative phosphorylation, which requires a large electrochemical driving force for ...
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Error correction due to background subtraction in ratiometric calcium measurements with CCD camera
Heliyon, 2020 Background: Ca2+ plays an important role in many physiological processes and an accurate study of these signals is important. In modern fluorescence microscopy, a charge-coupled device (CCD) camera is widely deployed for calcium imaging.
Vyacheslav M. Shkryl
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Simulation and calculation of the contribution of hyperpolarization-activated cyclic nucleotide-gated channels to action potentials [PDF]
Archives of Biological Sciences, 2016 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, which mediates the influx of cations, has an important role in action potential generation.
Liao Liping +6 more
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Frontiers in Oncology, 2022 A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of ...
Brigitte Pelzmann +19 more
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Redox Regulation of Mitochondrial Potassium Channels Activity
AntioxidantsRedox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska +3 more
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TRPM Family Channels in Cancer
Pharmaceuticals, 2018 Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains.
Aline Hantute-Ghesquier +3 more
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