Stochastic dynamics of remote knock-on permeation in biological ion channels [PDF]
, 2013 Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF).
P. V. E. McClintock +13 more
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Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis
Cells, 2020 It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
Aurélien Haustrate +2 more
doaj +1 more source
Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression
Cells, 2021 The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer.
Gonçalo Mesquita +3 more
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Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]
, 2011 The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
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Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current
ChannelsL-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia +5 more
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Machine learning-assisted genomic profiling to identify differences between Bacillus Calmette-Guérin (BCG) vaccine strains and non-BCG wild-type Mycobacterium bovis [PDF]
PeerJ Computer ScienceBackground Distinguishing Bacillus Calmette-Guérin (BCG) vaccines from pathogenic Mycobacterium bovis is critical in neonatal diagnostics, particularly where polymerase chain reaction (PCR) methods fail to detect key genomic variations in tuberculosis ...
Yunyun Shi +5 more
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Investigating Structure-Function Relationships in Ion Channels Using Unnatural Amino Acids [PDF]
, 2009 Ion channels are proteins that traverse the cell membrane and form gated pores that open and close in response to various stimuli. In order to experimentally probe aspects of ion channel functionality, we performed subtle structure function studies using
Eastwood, Amy Lynn
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Biological transport: membrane channels, a white noise flashing ratchet model [PDF]
, 2008 Màster en Biofísica Part I, curs 2007-2008. Part II la trobareu a: http://hdl.handle.net/2445/6722We explore biological transport across membrane channels from a physical point of view.
Gómez Orlandi, Javier
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TRPM8 Puts the Chill on Prostate Cancer
Pharmaceuticals, 2016 Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed countries. Several studies suggest that variations in calcium homeostasis are involved in carcinogenesis. Interestingly, (Transient Receptor Potential Melastatin member 8)
Guillaume P. Grolez, Dimitra Gkika
doaj +1 more source
Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels
Cells, 2021 Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak +2 more
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