P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
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A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer
Frontiers in Physiology, 2019 Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from the primary tumor to distant organs. At the molecular level, migration is the result of several coordinated events involving mechanical forces and cellular ...
Jimena Canales +14 more
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Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis
Cells, 2020 It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
Aurélien Haustrate +2 more
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Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression
Cells, 2021 The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer.
Gonçalo Mesquita +3 more
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Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current
ChannelsL-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia +5 more
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Machine learning-assisted genomic profiling to identify differences between Bacillus Calmette-Guérin (BCG) vaccine strains and non-BCG wild-type Mycobacterium bovis [PDF]
PeerJ Computer ScienceBackground Distinguishing Bacillus Calmette-Guérin (BCG) vaccines from pathogenic Mycobacterium bovis is critical in neonatal diagnostics, particularly where polymerase chain reaction (PCR) methods fail to detect key genomic variations in tuberculosis ...
Yunyun Shi +5 more
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FMI-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli [PDF]
, 2007 The molecular identity and pharmacological properties of mechanically gated ion channels in sensory neurons are poorly understood. We show that FM1-43, a styryl dye used to fluorescently label cell membranes, permeates mechanosensitive ion channels in ...
Wood John N +7 more
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TRPM8 Puts the Chill on Prostate Cancer
Pharmaceuticals, 2016 Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed countries. Several studies suggest that variations in calcium homeostasis are involved in carcinogenesis. Interestingly, (Transient Receptor Potential Melastatin member 8)
Guillaume P. Grolez, Dimitra Gkika
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Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels
Cells, 2021 Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak +2 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseCardiac channelopathies are inherited arrhythmias that can lead to sudden cardiac death. Despite Africa's extensive genomic diversity, African and African‐descent populations remain underrepresented in genetic research, creating gaps in variant ...
Choshiman Taib +2 more
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