Results 31 to 40 of about 804,799 (296)

Cardiac ion channels [PDF]

Channels, 2015
Ion channels are critical for all aspects of cardiac function, including rhythmicity and contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac pathophysiologies such as atrial fibrillation or angina. At the same time, off-target interactions of drugs with cardiac ion channels can be the cause of unwanted side ...
Birgit T, Priest, Jeff S, McDermott
openaire   +2 more sources

PTPRM Is Critical for Synapse Formation Regulated by Zinc Ion

Frontiers in Molecular Neuroscience, 2022
In the nervous system, the trace metal ion zinc is required for normal mammalian brain development and physiology. Zinc homeostasis is essential for the control of physiological and pathophysiological brain functions.
Xiaoqiang Mo, Xiaoqiang Mo, Mengxue Liu, Jihong Gong, Ying Mei, Huidan Chen, Huajun Mo, Xiaofei Yang, Jun Li   +8 more
doaj   +1 more source

Roles of ion channels in immune cells [PDF]

, 2016
The Editorial on the Research Topic - Roles of Ion Channels in Immune ...
Amanda eMacKenzie, Leanne eStokes, Leanne eStokes, Ronald eSluyter, Ronald eSluyter, Ronald eSluyter   +5 more
core   +4 more sources

A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer

Frontiers in Physiology, 2019
Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from the primary tumor to distant organs. At the molecular level, migration is the result of several coordinated events involving mechanical forces and cellular ...
Jimena Canales, Jimena Canales, Diego Morales, Diego Morales, Constanza Blanco, Constanza Blanco, José Rivas, José Rivas, Nicolás Díaz, Nicolás Díaz, Ioannis Angelopoulos, Ioannis Angelopoulos, Oscar Cerda, Oscar Cerda, Oscar Cerda   +14 more
doaj   +1 more source

Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis

Cells, 2020
It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
Aurélien Haustrate, Natalia Prevarskaya, V’yacheslav Lehen’kyi   +2 more
doaj   +1 more source

Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression

Cells, 2021
The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer.
Gonçalo Mesquita, Natalia Prevarskaya, Albrecht Schwab, V’yacheslav Lehen’kyi   +3 more
doaj   +1 more source

Machine learning-assisted genomic profiling to identify differences between Bacillus Calmette-Guérin (BCG) vaccine strains and non-BCG wild-type Mycobacterium bovis [PDF]

PeerJ Computer Science
Background Distinguishing Bacillus Calmette-Guérin (BCG) vaccines from pathogenic Mycobacterium bovis is critical in neonatal diagnostics, particularly where polymerase chain reaction (PCR) methods fail to detect key genomic variations in tuberculosis ...
Yunyun Shi, Jiang Yuan, Xiaobin Tang, Hai Luo, Genyun Tang, Zhiyong Shen   +5 more
doaj   +2 more sources

Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current

Channels
L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia, Daniela De Giorgis, Franco Medina, Tamara Hermosilla, Felipe Simon, Diego Varela   +5 more
doaj   +1 more source

TRPM8 Puts the Chill on Prostate Cancer

Pharmaceuticals, 2016
Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed countries. Several studies suggest that variations in calcium homeostasis are involved in carcinogenesis. Interestingly, (Transient Receptor Potential Melastatin member 8)
Guillaume P. Grolez, Dimitra Gkika
doaj   +1 more source

Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels

Cells, 2021
Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak, Piotr Bednarczyk, Adam Szewczyk   +2 more
doaj   +1 more source