Results 31 to 40 of about 276,631 (268)
Ion Channels and Migraine [PDF]
Headache: The Journal of Head and Face Pain, 2014 Migraine is one of the most common neurological disorders. Despite its prevalence, the basic physiology of the molecules and mechanisms that contribute to migraine headache is still poorly understood, making the discovery of more effective treatments extremely difficult.
Jin Yan, Gregory Dussor
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Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current
ChannelsL-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia +5 more
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TRPM8 Puts the Chill on Prostate Cancer
Pharmaceuticals, 2016 Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed countries. Several studies suggest that variations in calcium homeostasis are involved in carcinogenesis. Interestingly, (Transient Receptor Potential Melastatin member 8)
Guillaume P. Grolez, Dimitra Gkika
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Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels
Cells, 2021 Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak +2 more
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Error correction due to background subtraction in ratiometric calcium measurements with CCD camera
Heliyon, 2020 Background: Ca2+ plays an important role in many physiological processes and an accurate study of these signals is important. In modern fluorescence microscopy, a charge-coupled device (CCD) camera is widely deployed for calcium imaging.
Vyacheslav M. Shkryl
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Nature Communications, 2022 Photoactivable toxins targeting ion channels have great potential to control cell activity. Here the authors report HwTxIV-Nvoc, a UV light-cleavable and photoactivatable peptide that targets voltage-gated sodium channels; they validate this in cells ...
Jérôme Montnach +15 more
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Redox Regulation of Mitochondrial Potassium Channels Activity
AntioxidantsRedox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska +3 more
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TRPM Family Channels in Cancer
Pharmaceuticals, 2018 Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains.
Aline Hantute-Ghesquier +3 more
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Human Molecular Genetics, 2002 Ion channels serve many functions apart from electrical signal transduction: chemical signalling (Ca(2+) as a second messenger), transepithelial transport, regulation of cytoplasmic or vesicular ion concentration and pH, and regulation of cell volume. Therefore, ion channel dysfunction can cause diseases in many tissues.
Christian A, Hübner, Thomas J, Jentsch
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Simulation and calculation of the contribution of hyperpolarization-activated cyclic nucleotide-gated channels to action potentials [PDF]
Archives of Biological Sciences, 2016 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, which mediates the influx of cations, has an important role in action potential generation.
Liao Liping +6 more
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