Results 41 to 50 of about 804,799 (296)

Episodic neurologic disorders: syndromes, genes, and mechanisms. [PDF]

, 2013
Many neurologic diseases cause discrete episodic impairment in contrast with progressive deterioration. The symptoms of these episodic disorders exhibit striking variety.
Fu, Ying-Hui, Ptáček, Louis J, Russell, Jonathan F   +2 more
core   +2 more sources

Error correction due to background subtraction in ratiometric calcium measurements with CCD camera

Heliyon, 2020
Background: Ca2+ plays an important role in many physiological processes and an accurate study of these signals is important. In modern fluorescence microscopy, a charge-coupled device (CCD) camera is widely deployed for calcium imaging.
Vyacheslav M. Shkryl
doaj   +1 more source

In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Nature Communications, 2022
Photoactivable toxins targeting ion channels have great potential to control cell activity. Here the authors report HwTxIV-Nvoc, a UV light-cleavable and photoactivatable peptide that targets voltage-gated sodium channels; they validate this in cells ...
Jérôme Montnach, Laila Ananda Blömer, Ludivine Lopez, Luiza Filipis, Hervé Meudal, Aude Lafoux, Sébastien Nicolas, Duong Chu, Cécile Caumes, Rémy Béroud, Chris Jopling, Frank Bosmans, Corinne Huchet, Céline Landon, Marco Canepari, Michel De Waard   +15 more
doaj   +1 more source

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel [PDF]

, 2014
Transient receptor potential (TRP) channels, a superfamily of ion channels, can be divided into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels are tetrameric complexes consisting of 4 pore-forming subunits.
Birnbaumer, Lutz, Du, Juan, Huang, Yu, Ma, Xin, Shen, Bing, Yao, Xiaoqiang   +5 more
core   +1 more source

Redox Regulation of Mitochondrial Potassium Channels Activity

Antioxidants
Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska, Barbara Kalenik, Antoni Wrzosek, Adam Szewczyk   +3 more
doaj   +1 more source

TRPM Family Channels in Cancer

Pharmaceuticals, 2018
Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains.
Aline Hantute-Ghesquier, Aurélien Haustrate, Natalia Prevarskaya, V’yacheslav Lehen’kyi   +3 more
doaj   +1 more source

Simulation and calculation of the contribution of hyperpolarization-activated cyclic nucleotide-gated channels to action potentials [PDF]

Archives of Biological Sciences, 2016
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, which mediates the influx of cations, has an important role in action potential generation.
Liao Liping, Lin Xianguang, Hu Jielin, Wu Xin, Yang Xiaofei, Wang Wei, Li Chenhong   +6 more
doaj   +1 more source

Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels

Frontiers in Oncology, 2022
A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of ...
Brigitte Pelzmann, Brigitte Pelzmann, Ahmed Hatab, Ahmed Hatab, Susanne Scheruebel, Susanne Scheruebel, Sonja Langthaler, Theresa Rienmueller, Armin Sokolowski, Astrid Gorischek, Astrid Gorischek, Dieter Platzer, Dieter Platzer, Klaus Zorn-Pauly, Klaus Zorn-Pauly, Stephan W. Jahn, Thomas Bauernhofer, Thomas Bauernhofer, Wolfgang Schreibmayer, Wolfgang Schreibmayer   +19 more
doaj   +1 more source

Fluorescent Probes to Image the K_Ca3.1 Channel in Tumor Cells

Pharmaceutics
Background/Objectives: The Ca2+-activated K+ channel KCa3.1 is not only involved in physiological processes such as immune reactions and control of vascular tone, but is highly expressed in various tumor entities.
Insa Thale, Elke Naß, Laura Vinnenberg, Luca Matteo Todesca, Thomas Budde, Ivan Maisuls, Cristian A. Strassert, Albrecht Schwab, Bernhard Wünsch   +8 more
doaj   +1 more source

Regulation of the Mitochondrial BK_Ca Channel by the Citrus Flavonoid Naringenin as a Potential Means of Preventing Cell Damage

Molecules, 2020
Naringenin, a flavanone obtained from citrus fruits and present in many traditional Chinese herbal medicines, has been shown to have various beneficial effects on cells both in vitro and in vivo.
Anna Kicinska, Rafał P. Kampa, Jan Daniluk, Aleksandra Sek, Wieslawa Jarmuszkiewicz, Adam Szewczyk, Piotr Bednarczyk   +6 more
doaj   +1 more source