Results 41 to 50 of about 2,226,894 (256)

Error correction due to background subtraction in ratiometric calcium measurements with CCD camera

Heliyon, 2020
Background: Ca2+ plays an important role in many physiological processes and an accurate study of these signals is important. In modern fluorescence microscopy, a charge-coupled device (CCD) camera is widely deployed for calcium imaging.
Vyacheslav M. Shkryl
doaj   +1 more source

In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Nature Communications, 2022
Photoactivable toxins targeting ion channels have great potential to control cell activity. Here the authors report HwTxIV-Nvoc, a UV light-cleavable and photoactivatable peptide that targets voltage-gated sodium channels; they validate this in cells ...
Jérôme Montnach, Laila Ananda Blömer, Ludivine Lopez, Luiza Filipis, Hervé Meudal, Aude Lafoux, Sébastien Nicolas, Duong Chu, Cécile Caumes, Rémy Béroud, Chris Jopling, Frank Bosmans, Corinne Huchet, Céline Landon, Marco Canepari, Michel De Waard   +15 more
doaj   +1 more source

Investigating Structure-Function Relationships in Ion Channels Using Unnatural Amino Acids [PDF]

, 2009
Ion channels are proteins that traverse the cell membrane and form gated pores that open and close in response to various stimuli. In order to experimentally probe aspects of ion channel functionality, we performed subtle structure function studies using
Eastwood, Amy Lynn
core   +1 more source

Quantitative roles of ion channel dynamics on ventricular action potential [PDF]

, 2021
Mathematical models for the action potential (AP) generation of the electrically excitable cells including the heart are involved different mechanisms including the voltage-dependent currents with nonlinear time- and voltage-gating properties.
Sırcan, Ahmet Kürşad, Şengül Ayan, Sevgi, Sircan, Ahmet Kursad, Ayan, Sevgi Sengul, Ahmet Kürşad Sırcan, Sevgi Şengül Ayan   +5 more
core   +1 more source

Redox Regulation of Mitochondrial Potassium Channels Activity

Antioxidants
Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska, Barbara Kalenik, Antoni Wrzosek, Adam Szewczyk   +3 more
doaj   +1 more source

TRPM Family Channels in Cancer

Pharmaceuticals, 2018
Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains.
Aline Hantute-Ghesquier, Aurélien Haustrate, Natalia Prevarskaya, V’yacheslav Lehen’kyi   +3 more
doaj   +1 more source

Simulation and calculation of the contribution of hyperpolarization-activated cyclic nucleotide-gated channels to action potentials [PDF]

Archives of Biological Sciences, 2016
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, which mediates the influx of cations, has an important role in action potential generation.
Liao Liping, Lin Xianguang, Hu Jielin, Wu Xin, Yang Xiaofei, Wang Wei, Li Chenhong   +6 more
doaj   +1 more source

Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels

Frontiers in Oncology, 2022
A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of ...
Brigitte Pelzmann, Brigitte Pelzmann, Ahmed Hatab, Ahmed Hatab, Susanne Scheruebel, Susanne Scheruebel, Sonja Langthaler, Theresa Rienmueller, Armin Sokolowski, Astrid Gorischek, Astrid Gorischek, Dieter Platzer, Dieter Platzer, Klaus Zorn-Pauly, Klaus Zorn-Pauly, Stephan W. Jahn, Thomas Bauernhofer, Thomas Bauernhofer, Wolfgang Schreibmayer, Wolfgang Schreibmayer   +19 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Stochastic dynamics of remote knock-on permeation in biological ion channels [PDF]

, 2013
Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF).
P. V. E. McClintock, I. Kaufman, Eisenberg, R. S., Luchinsky, Dmitrii G., D. G. Luchinsky, Kaufman, Igor, Khovanov, I. A., I. A. Khovanov, R. Tindjong, McClintock, P. V. E., Eisenberg, Robert S., McClintock, Peter V. E., R. S. Eisenberg, Tindjong, Rodrigue   +13 more
core   +1 more source