Results 41 to 50 of about 2,126,685 (298)

Genetic Research on Cardiac Channelopathies in African and African‐Descent Populations: A Scoping Review

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Cardiac channelopathies are inherited arrhythmias that can lead to sudden cardiac death. Despite Africa's extensive genomic diversity, African and African‐descent populations remain underrepresented in genetic research, creating gaps in variant ...
Choshiman Taib, Nada El Makhzen, Hugues Abriel   +2 more
doaj   +1 more source

Error correction due to background subtraction in ratiometric calcium measurements with CCD camera

Heliyon, 2020
Background: Ca2+ plays an important role in many physiological processes and an accurate study of these signals is important. In modern fluorescence microscopy, a charge-coupled device (CCD) camera is widely deployed for calcium imaging.
Vyacheslav M. Shkryl
doaj   +1 more source

In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Nature Communications, 2022
Photoactivable toxins targeting ion channels have great potential to control cell activity. Here the authors report HwTxIV-Nvoc, a UV light-cleavable and photoactivatable peptide that targets voltage-gated sodium channels; they validate this in cells ...
Jérôme Montnach, Laila Ananda Blömer, Ludivine Lopez, Luiza Filipis, Hervé Meudal, Aude Lafoux, Sébastien Nicolas, Duong Chu, Cécile Caumes, Rémy Béroud, Chris Jopling, Frank Bosmans, Corinne Huchet, Céline Landon, Marco Canepari, Michel De Waard   +15 more
doaj   +1 more source

Imaging large cohorts of single ion channels and their activity [PDF]

, 2013
As calcium is the most important signaling molecule in neurons and secretory cells, amongst many other cell types, it follows that an understanding of calcium channels and their regulation of exocytosis is of vital importance.
Euan R. Brown, Katia eHiersemenzel, Brown, Euan R; id_orcid, Katia Hiersemenzel, Rory R. Duncan, Duncan, Rory R, Hiersemenzel, Katia, Rory R Duncan, Euan R Brown   +8 more
core   +1 more source

Redox Regulation of Mitochondrial Potassium Channels Activity

Antioxidants
Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska, Barbara Kalenik, Antoni Wrzosek, Adam Szewczyk   +3 more
doaj   +1 more source

TRPM Family Channels in Cancer

Pharmaceuticals, 2018
Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains.
Aline Hantute-Ghesquier, Aurélien Haustrate, Natalia Prevarskaya, V’yacheslav Lehen’kyi   +3 more
doaj   +1 more source

Ion Channels in the Heart [PDF]

Comprehensive Physiology, 2015
ABSTRACT Optimal cardiac function depends on proper timing of excitation and contraction in various regions of the heart, as well as on appropriate heart rate. This is accomplished via specialized electrical properties of various components of the system, including the sinoatrial node, atria, atrioventricular node,
Bartos, Daniel C, Grandi, Eleonora, Ripplinger, Crystal M   +2 more
openaire   +3 more sources

FMI-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli [PDF]

, 2007
The molecular identity and pharmacological properties of mechanically gated ion channels in sensory neurons are poorly understood. We show that FM1-43, a styryl dye used to fluorescently label cell membranes, permeates mechanosensitive ion channels in ...
Wood John N, Wood, John, Drew, LJ, Drew, Liam, Liam J Drew, John N Wood, Wood, JN, Drew Liam J   +7 more
core   +1 more source

Simulation and calculation of the contribution of hyperpolarization-activated cyclic nucleotide-gated channels to action potentials [PDF]

Archives of Biological Sciences, 2016
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, which mediates the influx of cations, has an important role in action potential generation.
Liao Liping, Lin Xianguang, Hu Jielin, Wu Xin, Yang Xiaofei, Wang Wei, Li Chenhong   +6 more
doaj   +1 more source

Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels

Frontiers in Oncology, 2022
A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of ...
Brigitte Pelzmann, Brigitte Pelzmann, Ahmed Hatab, Ahmed Hatab, Susanne Scheruebel, Susanne Scheruebel, Sonja Langthaler, Theresa Rienmueller, Armin Sokolowski, Astrid Gorischek, Astrid Gorischek, Dieter Platzer, Dieter Platzer, Klaus Zorn-Pauly, Klaus Zorn-Pauly, Stephan W. Jahn, Thomas Bauernhofer, Thomas Bauernhofer, Wolfgang Schreibmayer, Wolfgang Schreibmayer   +19 more
doaj   +1 more source