Results 21 to 30 of about 276,631 (268)
Ion channels and ion selectivity [PDF]
Essays in Biochemistry, 2017 Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential.
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PTPRM Is Critical for Synapse Formation Regulated by Zinc Ion
Frontiers in Molecular Neuroscience, 2022 In the nervous system, the trace metal ion zinc is required for normal mammalian brain development and physiology. Zinc homeostasis is essential for the control of physiological and pathophysiological brain functions.
Xiaoqiang Mo +8 more
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Ion channel activity drives ion channel expression [PDF]
The Journal of Physiology, 1998 During embryonic development, excitable cells acquire a repertoire of ion channels that finely tune their electrical properties. Although the mechanisms by which an excitable cell selects its complement of ion channels are poorly defined, cell-autonomous as well as non-autonomous programmes of differentiation have been implicated.
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A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer
Frontiers in Physiology, 2019 Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from the primary tumor to distant organs. At the molecular level, migration is the result of several coordinated events involving mechanical forces and cellular ...
Jimena Canales +14 more
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Ubiquitylation of Ion Channels
Physiology, 2005 Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ...
Abriel H, Staub O
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Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis
Cells, 2020 It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
Aurélien Haustrate +2 more
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Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression
Cells, 2021 The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer.
Gonçalo Mesquita +3 more
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Ion Channel Pharmacology [PDF]
Neurotherapeutics, 2007 Because ion channels are involved in many cellular processes, drugs acting on ion channels have long been used for the treatment of many diseases, especially those affecting electrically excitable tissues. The present review discusses the pharmacology of voltage-gated and neurotransmitter-gated ion channels involved in neurologic diseases, with ...
CONTE, Diana +2 more
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Machine learning-assisted genomic profiling to identify differences between Bacillus Calmette-Guérin (BCG) vaccine strains and non-BCG wild-type Mycobacterium bovis [PDF]
PeerJ Computer ScienceBackground Distinguishing Bacillus Calmette-Guérin (BCG) vaccines from pathogenic Mycobacterium bovis is critical in neonatal diagnostics, particularly where polymerase chain reaction (PCR) methods fail to detect key genomic variations in tuberculosis ...
Yunyun Shi +5 more
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