Results 21 to 30 of about 2,226,894 (256)

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

Frontiers in Oncology, 2021
Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, breast cancer still caused ...
María Paz Saldías, María Paz Saldías, Diego Maureira, Diego Maureira, Octavio Orellana-Serradell, Octavio Orellana-Serradell, Ian Silva, Ian Silva, Boris Lavanderos, Boris Lavanderos, Pablo Cruz, Pablo Cruz, Camila Torres, Camila Torres, Mónica Cáceres, Mónica Cáceres, Mónica Cáceres, Oscar Cerda, Oscar Cerda, Oscar Cerda   +19 more
doaj   +1 more source

SCN1A channelopathies: Navigating from genotype to neural circuit dysfunction

Frontiers in Neurology, 2023
The SCN1A gene is strongly associated with epilepsy and plays a central role for supporting cortical excitation-inhibition balance through the expression of NaV1.1 within inhibitory interneurons.
Alexander Bryson, Steven Petrou, Steven Petrou   +2 more
doaj   +1 more source

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

, 2013
Direct electrical access to presynaptic ion channels has hitherto been limited to large specialized terminals such as the calyx of Held or hippocampal mossy fiber bouton.
Rusakov, Dmitri A., Korchev, Yuri E., Moss, Guy WJ, Ermolyuk, Yaroslav S, Volynski, Kirill E, Bailey, Russell J, Bailey, Russell J., Moss, Guy W.J., Klenerman, David, Volynski, Kirill E., Rusakov, Dmitri A, Novak, Pavel, Shevchuk, Andrew I, Bushby, Andrew J, Vivekananda, Umesh, Kullmann, Dimitri M., Kullmann, Dimitri M, Shevchuk, Andrew I., Gorelik, Julia, Korchev, Yuri E, Ermolyuk, Yaroslav S., Bushby, Andrew J., Benton, DCH, Caldwell, M, Moss, GWJ, Smart, TG, Robertson, AD   +26 more
core   +1 more source

Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia

Frontiers in Physiology, 2021
Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population.
Isabelle Bidaud, Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Antony Chung You Chong, Angelo G. Torrente, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Matteo E. Mangoni, Pietro Mesirca, Pietro Mesirca   +19 more
doaj   +1 more source

Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex

Frontiers in Molecular Neuroscience, 2021
Calcium-dependent synaptic vesicle exocytosis is mediated by SNARE complex formation. The transition from the Munc18-1/syntaxin-1 complex to the SNARE complex is catalyzed by the Munc13-1 MUN domain and involves at least two conformational changes ...
Jihong Gong, Xianping Wang, Chaoyang Cui, Yuyang Qin, Ziqi Jin, Cong Ma, Xiaofei Yang   +6 more
doaj   +1 more source

Biophysical characterization and modelling of SCN1A gain-of-function predicts interneuron hyperexcitability and a predisposition to network instability through homeostatic plasticity

Neurobiology of Disease, 2023
SCN1A gain-of-function variants are associated with early onset developmental and epileptic encephalopathies (DEEs) that possess distinct clinical features compared to Dravet syndrome caused by SCN1A loss-of-function.
Géza Berecki, Alexander Bryson, Tilman Polster, Steven Petrou   +3 more
doaj   +1 more source

Calcium-permeable ion channels in control of autophagy and cancer

Frontiers in Physiology, 2013
Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis.
Artem eKondratskyi, Maya eYassine, Kateryna eKondratska, Roman eSkryma, Christian eSlomianny, Natalia ePrevarskaya   +5 more
doaj   +1 more source

Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients [PDF]

, 2008
Previously, functional mapping of channels has been achieved by measuring the passage of net charge and of specific ions with electrophysiological and intracellular fluorescence imaging techniques.
Collis, Leon P., Smith, Peter J. S., Messerli, Mark A., Smith, Peter J.S.   +3 more
core   +1 more source

Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]

, 2011
The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core   +1 more source

PTPRM Is Critical for Synapse Formation Regulated by Zinc Ion

Frontiers in Molecular Neuroscience, 2022
In the nervous system, the trace metal ion zinc is required for normal mammalian brain development and physiology. Zinc homeostasis is essential for the control of physiological and pathophysiological brain functions.
Xiaoqiang Mo, Xiaoqiang Mo, Mengxue Liu, Jihong Gong, Ying Mei, Huidan Chen, Huajun Mo, Xiaofei Yang, Jun Li   +8 more
doaj   +1 more source