Results 11 to 20 of about 276,631 (268)
Frontiers in Cellular Neuroscience, 2023 The possibilities of using nanoparticle materials based on cerium dioxide (CNPs) are exciting since they are low toxic and have specific redox, antiradical properties.
Vita V. Hanzha +4 more
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Scientific Reports, 2021 The activation of mitochondrial large conductance calcium-activated potassium (mitoBKCa) channels increases cell survival during ischemia/reperfusion injury of cardiac cells.
Shur Gałecka +4 more
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TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer
Frontiers in Oncology, 2021 Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, breast cancer still caused ...
María Paz Saldías +19 more
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Journal of Biological Chemistry, 2011 Ion channels are specialized transmembrane proteins that permit the passive flow of ions following their electrochemical gradients. In the airways, ion channels participate in the production of epithelium-based hydroelectrolytic secretions and in the control of intracellular Ca(2+) levels that will ultimately activate almost all lung cells, either ...
Miguel A, Valverde +5 more
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SCN1A channelopathies: Navigating from genotype to neural circuit dysfunction
Frontiers in Neurology, 2023 The SCN1A gene is strongly associated with epilepsy and plays a central role for supporting cortical excitation-inhibition balance through the expression of NaV1.1 within inhibitory interneurons.
Alexander Bryson +2 more
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Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex
Frontiers in Molecular Neuroscience, 2021 Calcium-dependent synaptic vesicle exocytosis is mediated by SNARE complex formation. The transition from the Munc18-1/syntaxin-1 complex to the SNARE complex is catalyzed by the Munc13-1 MUN domain and involves at least two conformational changes ...
Jihong Gong +6 more
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Neurobiology of Disease, 2023 SCN1A gain-of-function variants are associated with early onset developmental and epileptic encephalopathies (DEEs) that possess distinct clinical features compared to Dravet syndrome caused by SCN1A loss-of-function.
Géza Berecki +3 more
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Frontiers in Physiology, 2021 Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population.
Isabelle Bidaud +19 more
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Calcium-permeable ion channels in control of autophagy and cancer
Frontiers in Physiology, 2013 Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis.
Artem eKondratskyi +5 more
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Langmuir, 2013 The objective of this historical review is to recall the development of the field of synthetic ion channels over the past three decades. The most inspiring and influential breakthroughs with regard to structure and function are brought together to give the general reader an easily accessible understanding of the field.
Sakai Naomi, Matile Stefan
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