Results 71 to 80 of about 58,639 (306)

Salinomycin and Other Polyether Ionophores Are a New Class of Antiscarring Agent*

Journal of Biological Chemistry, 2014
Background: Excessive scar formation is a debilitating complication underlying many diseases of the eye, lungs, and skin. Results: We identified salinomycin as an inhibitor of TGFβ-dependent cell signaling.
C. Woeller, Charles W O'loughlin, E. Roztocil, S. Feldon, R. Phipps   +4 more
semanticscholar   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides

Molecules, 2014
A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods.
Michał Antoszczak, Ewa Maj, Agnieszka Napiórkowska, Joanna Stefańska, Ewa Augustynowicz-Kopeć, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski, Adam Huczyński   +8 more
doaj   +1 more source

Ionophore-Based Potassium Selective Fluorescent Organosilica Nano-Optodes Containing Covalently Attached Solvatochromic Dyes

Chemosensors, 2022
Fluorescent nanoprobes containing ionophores and solvatochromic dyes (SDs) were previously reported as an alternative to chromoionophore-based nano-optodes. However, the small-molecular SDs are prone to leakage and sequestration in complex samples. Here,
Yupu Zhang, Xinfeng Du, Xiaojiang Xie
doaj   +1 more source

In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei [PDF]

, 2016
Background: African trypanosomes are the causative agents of sleeping sickness in humans and nagana disease in livestock animals. As the few drugs available for treatment of the diseases have limited efficacy and produce adverse reactions, new and better
A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Scherzad, Adam Huczyński, AH Fairlamb, D Steverding, DH Molyneux, Dietmar Steverding, E Matovu, GE Moore, H Hirumi, K Merschjohann, M Antoszczak, M Antoszczak, Michał Antoszczak, S Nwaka, SJ Collins, SV Barrett, T Baltz, V Delespaux, W Huber   +24 more
core   +1 more source

Biocompatible Magnetopyroelectric Composite Films for Cell Stimulation

Advanced Science, EarlyView.
Magnetopyroelectric films couple Fe3O4 nanoparticles with pyroelectric P(VDF‐TrFE) to turn alternating magnetic fields into controlled heat and pyroelectric currents. This heavy‐metal free platform safely boosts neural progenitor cells differentiation via synergistic thermal and pyroelectrical cues, engages AKT and calcium pathways, and opens practical
Hao Ye, Joaquin Llacer‐Wintle, Semih Sevim, Elric Zhang, Denis von Arx, Lukas Hertle, Martina Accursi, Minsoo Kim, Josep Puigmartí‐Luis, Bradley J. Nelson, Xiang‐Zhong Chen, Salvador Pané   +11 more
wiley   +1 more source

Artificial oocyte activation using Ca2+ ionophores following intracytoplasmic sperm injection for low fertilization rate [PDF]

, 2023
Kazuhiro Akashi, Mitsutoshi Yamada, Seung Chik Jwa, Hiroki Utsuno, Shintaro Kamijo, Yasushi Hirota, Mamoru Tanaka, Yutaka Osuga, Naoaki Kuji   +8 more
openalex   +1 more source

Inactivation of murine norovirus on a range of copper alloy surfaces is accompanied by loss of capsid integrity

, 2015
Norovirus is one of the most common causes of acute viral gastroenteritis. The virus is spread via the fecal-oral route, most commonly from infected food and water, but several outbreaks have originated from contamination of surfaces with infectious ...
Keevil, C William, Summersgill, Emma N., Warnes, Sarah L.   +2 more
core   +1 more source

Recombinant anticoccidial vaccines - a cup half full? [PDF]

, 2017
Eimeria species parasites can cause the disease coccidiosis, most notably in chickens. The occurrence of coccidiosis is currently controlled through a combination of good husbandry, chemoprophylaxis and/or live parasite vaccination; however, scalable ...
Ahmad, Arnott, Awad, Bafundo, Blake, Blake, Blake, Brothers, Brown, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Chen, Clark, Clark, Cornelissen, Cosentino, Crane, Dalloul, Damer P. Blake, Ding, Ding, Djemai, Du, Eckford, Fiona M. Tomley, Fischbach, Fluit, Gedik, Gowen, Hedhli, Hoan, Huang, Iván Pastor-Fernández, Jahn, Jang, Jang, Jenkins, Jenkins, Jenkins, Jiang, Joyner, Karlsson, Keestra, Klotz, Koblansky, Konjufca, Kundu, Kvicerova, Labbe, Lai, Lassen, Lee, Li, Li, Lillehoj, Liu, Long, Marugan-Hernandez, Matthew J. Nolan, McDonald, McDonald, Min, Naciri, Nolan, Peek, Peek, Plattner, Pogonka, Reid, Ruff, Rugarabamu, Salazar Gonzalez, Sathish, Schaap, Shah, Sharman, Shen, Shirley, Shirley, Smith, Song, Song, Song, Song, Song, Song, Song, Subramanian, Sun, Takala, Tang, Tomley, Tomley, Tomley, Vermeulen, Vrba, Wallach, Wang, Wang, Williams, Williams, Williams, Williams, Williams, Witcombe, Wu, Xu, Xu, Yin, Yin, Yun, Zhang, Zhang, Zimmermann   +119 more
core   +2 more sources

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source