Results 61 to 70 of about 1,272,062 (259)

Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology [PDF]

, 2009
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas ...
Andreou, A.
core  

Functional reconstitution of the insect odorant receptor co-receptor in a tethered lipid bilayer membrane [PDF]

, 2021
As membrane proteins are among the most important drug targets, it is critical to study membrane proteins to improve drug design. However, due to the myriad roles fulfilled by the cellular membrane, it is a highly complex environment and challenging to ...
Bernhard , Schuster, Colm , Carraher, Ulrich, Ramach, Wolfgang, Knoll, Chiara, D\u27Onofrio, Jakob, Andersson, David , Kleinheinz   +6 more
core   +2 more sources

GRIA3 p.Met661Thr variant in a female with developmental epileptic encephalopathy

Human Genome Variation, 2023
The X-linked human glutamate receptor subunit 3 (GRIA3) gene (MIM *305915, Xq25) encodes ionotropic α amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-type glutamate receptor subunit 3, which mediates postsynaptic neurotransmission.
Satomi Okano, Yoshio Makita, Akie Miyamoto, Genya Taketazu, Kayano Kimura, Ikue Fukuda, Hajime Tanaka, Kumiko Yanagi, Tadashi Kaname   +8 more
doaj   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Identification and expression analysis of chemosensory receptors in the tarsi of fall armyworm, Spodoptera frugiperda (J. E. Smith)

Frontiers in Physiology, 2023
Chemosensation of tarsi provides moths with the ability to detect chemical signals which are important for food recognition. However, molecular mechanisms underlying the chemosensory roles of tarsi are still unknown.
Jun-Feng Dong, Hai-Bo Yang, Ding-Xu Li, Hong-Qi Yu, Cai-Hong Tian   +4 more
doaj   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Kainate receptor function in rodent subcortical visual processing. [PDF]

, 2007
Glutamate is found throughout the central nervous system and has been shown to be an important excitatory neurotransmitter in the visual system. There are two subdivisions of receptor on which this ubiquitous neurotransmitter acts, metabotropic (mGluR ...
Pothecary, C.A.
core  

Genome-Wide Characterization of Four Gastropod Species Ionotropic Receptors Reveals Diet-Linked Evolutionary Patterns of Functional Divergence

Animals
Ionotropic receptors (IRs) are a divergent subfamily of ionotropic glutamate receptors (iGluRs) that detect olfactory and environmental cues, influencing behaviors such as foraging and adaptation.
Gang Wang, Yi-Qi Sun, Fang Wang, Zhi-Yong Wang, Ni-Ying Sun, Meng-Jun Wei, Yu-Tong Shen, Yi-Jia Li, Quan-Qing Sun, Yushinta Fujaya, Xun-Guang Bian, Wen-Qi Yang, Kianann Tan   +12 more
doaj   +1 more source

Identification of Candidate Chemosensory Receptors in the Antennae of the Variegated Cutworm, Peridroma saucia Hübner, Based on a Transcriptome Analysis

Frontiers in Physiology, 2020
Insect chemoreception, including olfaction and gustation, involves several families of genes, including odorant receptors (ORs), ionotropic receptors (IRs), and gustatory receptors (GRs).
Ya-Lan Sun, Jun-Feng Dong, Nan Gu, Shao-Li Wang   +3 more
doaj   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source