Results 81 to 90 of about 59,355 (255)

Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]

, 2002
Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R., Braun, G. S., Horster, M. F., Huber, S. M., Tschop, J.   +4 more
core   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex

Cell Reports, 2012
Ionotropic glutamate receptors assemble as homo- or heterotetramers. One well-studied heteromeric complex is formed by the kainate receptor subunits GluK2 and GluK5.
Andreas Reiner, Ryan J. Arant, Ehud Y. Isacoff   +2 more
doaj   +1 more source

Differential Regulation of Ionotropic Glutamate Receptors [PDF]

Biophysical Journal, 2007
Ionotropic glutamate receptors (iGluRs), a family of ligand-gated ion channels, are responsible for the majority of fast excitatory neurotransmission in the central nervous system. Within this family, different members serve distinct roles at glutamatergic synapses.
Stoll, Laura, Hall, James, Van Buren, Nick, Hall, Amanda, Knight, Lee, Morgan, Andy, Zuger, Sarah, Van Deusen, Halena, Gentile, Lisa   +8 more
openaire   +2 more sources

Tannic Acid Mitigates Monosodium Glutamate‐Induced Cortical Damage by Modulating Synaptic and Calcium‐Related Gene and Protein Expression

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neurotoxicity induced by excessive glutamatergic signaling is associated with synaptic dysfunction, calcium imbalance, and oxidative stress, which are key molecular events implicated in several neurodegenerative conditions. Monosodium glutamate (MSG), a common flavor enhancer, may exert neurotoxic effects, particularly on synaptic integrity ...
Medine Sibel Karagac, Enver Fehim Koçpinar, Hamid Ceylan   +2 more
wiley   +1 more source

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
Burnstock, G, King, B F, Spyer, K M, Thomas, T, Townsend-Nicholson, A, Wildman, Scott S.P.   +5 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Identification of candidate chemosensory receptors based on transcriptome analysis in the monophagous insect Protegira songi (Lepidoptera, Noctuidae)

BMC Genomics
Background Insects perceive chemical cues from conspecifics and hosts through their sensitive chemosensory system. The chemosensory receptors, which are mainly represented by odorant receptors (ORs), ionotropic receptors (IRs), and gustatory receptors ...
Mengqing Zhang, Yue Zhang, Bowei Chen, Xihui Wang, Wei Zhao, Yechen Tan, Yuzong Huang, Sijing Ren, Hui Chen, Zhi Li, Yixi Zhang, Siqi Xia, Erna Xun, Xinglong Huang   +13 more
doaj   +1 more source

Thermal Stress-Induced Alterations to Oxylipin Signal Receptors in the Cnidarian-Dinoflagellate Symbiosis. [PDF]

Environ Microbiol
Thermal stress significantly alters signalling receptor abundance in the model cnidarian Exaiptasia diaphana. TRPA1, EP2 and GRIK2 increased under elevated temperatures, while EP4 remained unchanged, indicating differential thermal modulation of oxylipin‐ and glutamate‐linked pathways.
Gamba AG, Oakley CA, Ashley IA, Grossman AR, Weis VM, Suggett DJ, Davy SK.   +6 more
europepmc   +2 more sources

Conservation of Olfactory Avoidance in Drosophila Species and Identification of Repellents for Drosophila suzukii. [PDF]

, 2015
Flying insects use olfaction to navigate towards fruits in complex odor environments with remarkable accuracy. Some fruits change odor profiles substantially during ripening and related species can prefer different stages.
Krause Pham, Christine, Ray, Anandasankar   +1 more
core