Results 61 to 70 of about 3,953,913 (344)
Thorax, 2013 Effective therapies for the 10% of patients with 'severe' asthma remain elusive, while other pulmonary diseases such as idiopathic pulmonary fibrosis are currently untreatable. Many cellular processes rely heavily on signals delivered by changes in the intracellular-free Ca(2+) concentration, in many cases relying on Ca(2+) influx from the ...
Peter, Bradding, Heike, Wulff
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Frontiers in NeuroscienceIntroductionOne-third of epileptic patients are resistant to conventional treatments. Vagus nerve stimulation is a promising therapy, especially when applied early during seizure onset.
Elise Collard +10 more
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Spectroscopy of low-phonon-energy Er:La2O2S oxysulfide [PDF]
EPJ Web of ConferencesLanthanum oxysulfide powders doped with Erbium ions were fabricated by the combustion method followed by sulfurization at 1000 °C under H2S + N2 atmosphere. X-ray diffraction confirms their single-phase nature (sp. gr. P-3m1).
Poitou Marine +5 more
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Thermodynamic metal melting bases. Foundry production and metallurgy
Литьë и металлургия, 2020 Based on thermodynamic calculations, it is shown that metal melting is an equilibrium process that occurs at a constant temperature. In melting, microcrystals mainly disintegrate into nanocrystals.
E. I. Marukovich, V. Yu. Stetsenko
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Vagus nerve electroneurogram-based detection of acute kainic acid induced seizures
Frontiers in NeuroscienceSeizures produce autonomic symptoms, mainly sympathetic but also parasympathetic in origin. Within this context, the vagus nerve is a key player as it carries information from the different organs to the brain and vice versa.
Elena Acedo Reina +9 more
doaj +1 more source
Thermodynamic metal crystallization basics
Литьë и металлургия, 2020 On the basis of thermodynamic calculations it is shown that crystallization of metals is a thermodynamic process, which takes place mainly at constant temperature.
E. I. Marukovich, V. Yu. Stetsenko
doaj +1 more source
Ion channels and ion selectivity [PDF]
Essays in Biochemistry, 2017 Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential.
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source