Results 201 to 210 of about 41,736 (257)

PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gα_q. [PDF]

Proc Natl Acad Sci U S A
Falzone ME, Banerjee P, MacKinnon R.
europepmc   +1 more source

Beta2-adrenergic receptor activation increases susceptibility to arrhythmogenesis in aging heart by impairing repolarization reserve via G_iβγ-PLC signaling pathway. [PDF]

Sci Rep
Zou S, Wang Y, Chen J, Yan L, Gao L, Li K, Wang X, Li C.   +7 more
europepmc   +1 more source

Guardians of T-Cell Ca²⁺ Stores: SERCA Pumps Integrated Within Complex Functional and Disease-State Signaling Dynamics. [PDF]

Cells
Uddin MDN, Thomas DW.
europepmc   +1 more source

The role and signal pathways of opsin 3 in the skin: from light perception to pathophysiological mechanisms. [PDF]

Front Med (Lausanne)
Zhang Q, Feng Y.
europepmc   +1 more source

Dual regulation of IP3 receptors by IP3 and PIP2 controls the transition from local to global Ca2+ signals [PDF]

Molecular Cell
The spatial organization of inositol 1,4,5-trisphosphate (IP3)-evoked Ca2+ signals underlies their versatility. Low stimulus intensities evoke Ca2+ puffs, localized Ca2+ signals arising from a few IP3 receptors (IP3Rs) within a cluster tethered beneath ...
Colin Taylor, Maria Marti-Solano
exaly   +3 more sources

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Reduced IP3 sensitivity of IP3 receptor in Purkinje neurons

Neuroreport, 2001
The inositol 1,4,5-trisphosphate receptor (IP3R) is highly expressed in Purkinje neurons (PNs) and is thought to be essential for the induction of long-term depression at parallel-fiber-PN synapses. Here, by imaging the fluorescence intensity of the low-affinity Ca2+ indicator inside the Ca2+ stores in the permeabilized single PNs, we analyzed the ...
A, Fujiwara, K, Hirose, T, Yamazawa, M, Iino   +3 more
openaire   +2 more sources

Dynamic clustering of IP3 receptors by IP3

Biochemical Society Transactions, 2012
The versatility of Ca2+ as an intracellular messenger stems largely from the impressive, but complex, spatiotemporal organization of the Ca2+ signals. For example, the latter when initiated by IP3 (inositol 1,4,5-trisphosphate) in many cells manifest hierarchical recruitment of elementary Ca2+ release events (‘blips’ and then ‘puffs’) en route to ...
openaire   +2 more sources

Plasma membrane IP3 receptors

Biochemical Society Transactions, 2006
IP3Rs (inositol 1,4,5-trisphosphate receptors) are expressed in the membranes of non-mitochondrial organelles in most animal cells, but their presence and role within the plasma membrane are unclear. Whole-cell patch–clamp recording from DT40 cells expressing native or mutated IP3Rs has established that each cell expresses just two or three functional ...
C W, Taylor, O, Dellis
openaire   +2 more sources

Probes for manipulating and monitoring IP3

Cell Calcium, 2017
Inositol 1,4,5-trisphosphate (IP3) is an important second messenger produced via G-protein-coupled receptor- or receptor tyrosine kinase-mediated pathways. IP3 levels induce Ca2+ release from the endoplasmic reticulum (ER) via IP3 receptor (IP3R) located in the ER membrane. The resultant spatiotemporal pattern of Ca2+ signals regulates diverse cellular
Akitoshi, Miyamoto, Katsuhiko, Mikoshiba
openaire   +2 more sources