Results 81 to 90 of about 1,266,606 (191)

Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells

Frontiers in Immunology, 2017
Regulatory T cells (Tregs) control key events of immune tolerance, primarily by suppression of effector T cells. We previously revealed that Tregs rapidly suppress T cell receptor (TCR)-induced calcium store depletion in conventional CD4+CD25− T cells ...
Rubin N. Joshi, Nadine A. Binai, Nadine A. Binai, Francesco Marabita, Zhenhua Sui, Amnon Altman, Albert J. R. Heck, Albert J. R. Heck, Jesper Tegnér, Jesper Tegnér, Jesper Tegnér, Angelika Schmidt   +11 more
doaj   +1 more source

Type 3 IP3 receptor: Its structure, functions, and related disease implications. [PDF]

Channels (Austin), 2023
Wu L, Chen J.
europepmc   +1 more source

Maturation-associated increase in IP3 receptor type 1: role in conferring increased IP3 sensitivity and Ca2+ oscillatory behavior in mouse eggs [PDF]

, 2003
Maturation of mouse oocytes is accompanied by an increase in sensitivity to inositol 1,4,5-trisphosphate (IP3)-mediated release of intracellular calcium.
Xu, Zhe, Williams, Carmen J, Kopf, Gregory S, Schultz, Richard M   +3 more
core   +1 more source

Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage.

PLoS Biology
Successful initiation of animal development requires activation of the egg immediately prior to fusion of gamete pronuclei. In all taxa, this is initiated by waves of calcium transients which transverse across the egg.
Jiajia Ma, Tom J Carney
doaj   +1 more source

Astrocyte IP3R2-dependent Ca2+ signaling is not a major modulator of neuronal pathways governing behavior.

Frontiers in Behavioral Neuroscience, 2014
Calcium-dependent release of gliotransmitters by astrocytes is reported to play a critical role in synaptic transmission and be necessary for long-term potentiation (LTP), long-term depression (LTD) and other forms of synaptic modulation that are ...
Jeremy ePetravicz, Jeremy ePetravicz, Kristen M. Boyt, Ken D. McCarthy   +3 more
doaj   +1 more source

Imiquimod induces a Toll-like receptor 7-independent increase in intracellular calcium via IP3 receptor activation

, 2014
Imiquimod is an itch-promoting, small, synthetic compound that is generally used to treat genital warts and basal cell carcinoma. The pruritogenic effect of imiquimod is considered to be due to TLR7 activation; however that idea has been challenged by ...
Min, Hyunjung, Lee, Sung Joong, Choi, Se-Young, Hwang, Heehong, Jung, Sung Jun, Kim, Donghoon, Yu, Seong-Woon   +6 more
core   +1 more source

Synthetic partial agonists reveal key steps in IP3 receptor activation [PDF]

, 2009
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ubiquitous intracellular Ca2+ channels. IP3 binding to the IP 3-binding core (IBC) near the N terminus initiates conformational changes that lead to opening of a pore.
Emily J A Taylor, Riley, A, Olivier Dellis, Taylor, EJA, Barry V L Potter, Ana M Rossi, Potter, BVL, Colin W Taylor, Riley, Andrew, Rahman, T, Taylor, CW, Taufiq Rahman, Andrew M Riley, Rossi, AM, Valery G Veresov, Veresov, VG, Stephen C Tovey, Dellis, O, Tovey, SC   +18 more
core   +1 more source

A Dominant-Negative Mutant of ANXA7 Impairs Calcium Signaling and Enhances the Proliferation of Prostate Cancer Cells by Downregulating the IP3 Receptor and the PI3K/mTOR Pathway. [PDF]

Int J Mol Sci, 2023
Srivastava M, Bera A, Eidelman O, Tran MB, Jozwik C, Glasman M, Leighton X, Caohuy H, Pollard HB.   +8 more
europepmc   +1 more source

Oxidative Stress Alters IP3 Receptor Function in the Neuronal Cell Line HT22

, 2008
Sandra Longoria., Oxidative Stress Alters IP3 Receptor Function in the Neuronal Cell Line HT22, Master of Science (Biomedical Sciences), May 2008, 72 pp., 25 Figures. Oxidative stress contributes to the genesis of several neurodegenerative disorders such
Longoria, Sandra
core   +1 more source

Structural titration reveals Ca²⁺-dependent conformational landscape of the IP₃ receptor. [PDF]

Nat Commun, 2023
Paknejad N, Sapuru V, Hite RK.
europepmc   +1 more source