Results 71 to 80 of about 1,266,606 (191)

Deciphering the multi-site phos-code of IRBIT underlying its binding to IP3R

Communications Biology
IRBIT has been previously shown to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) via a serine-rich segment. Although the interaction between IRBIT and IP3R is phosphorylation dependent, it is unclear which particular ...
Qing Lin, Hao Yang, Qi Feng, Tomohide Sumi, Kozo Hamada, Yi Qian, Fang Bai, Akihiro Mizutani, Katsuhiko Mikoshiba   +8 more
doaj   +1 more source

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum

Cell Reports
Summary: Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to ...
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel   +13 more
doaj   +1 more source

Carbachol-Induced Secretion and Homologous Desensitization in Rat Basophilic Leukemia (RBL-2H3) Cells Transfected With Human m2 Muscarinic Acetylcholine Receptors

Journal of Pharmacological Sciences, 2004
Carbachol (CCh) caused a dose-dependent release of β-hexosaminidase and an increase in the production of inositol 1,4,5-trisphosphate (IP3) in RBL-2H3 cells transfected with m2 mAChR cDNA (RBL-m2 cells).
Kazuhiko Oishi, Akihiro Sakurai, Noriyasu Seki, Tomokazu Yoshizumi, Masaatsu K. Uchida   +4 more
doaj   +1 more source

Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action.

PLoS ONE, 2012
Methylphenidate (MPH), commercially called Ritalin or Concerta, has been widely used as a drug for Attention Deficit Hyperactivity Disorder (ADHD). Noteworthily, growing numbers of young people using prescribed MPH improperly for pleasurable enhancement,
Chun-Lei Zhang, Ze-Jun Feng, Yue Liu, Xiao-Hua Ji, Ji-Yun Peng, Xue-Han Zhang, Xue-Chu Zhen, Bao-Ming Li   +7 more
doaj   +1 more source

Spatial-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors

Seminars in Cell & Developmental Biology, 2019
The patterning of cytosolic Ca2+ signals in space and time underlies their ubiquitous ability to specifically regulate numerous cellular processes. Signals mediated by liberation of Ca2+ sequestered in the endoplasmic reticulum (ER) through inositol trisphosphate receptor (IP3R) channels constitute a hierarchy of events; ranging from openings of ...
Lock, Jeffrey T, Smith, Ian F, Parker, Ian   +2 more
openaire   +5 more sources

IP3 Receptors [PDF]

Biophysical Journal, 2008
Colin W. Taylor, Ana M. Rossi
openaire   +2 more sources

Function and Regulation of Endothelin Type A Receptor–Operated Transient Receptor Potential Canonical Channels

Journal of Pharmacological Sciences, 2011
.: The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca2+ entry (ROCE) triggered by activation of endothelin type A receptor (ETAR) and to clarify the importance of ...
Takahiro Horinouchi, Koji Terada, Tsunaki Higa, Hiroyuki Aoyagi, Tadashi Nishiya, Hiroyuki Suzuki, Soichi Miwa   +6 more
doaj   +1 more source

Arabidopsis Ca2+-dependent protein kinase CPK3 mediates relationship of putative inositol triphosphate receptor with slow-type anion channel

Biologia Plantarum, 2011
It has been suggested in Arabidopsis thaliana (L.) Heynh. cv. Columbia that, contrary to 30 μM abscisic acid (ABA), 20 μM ABA induces guard cell Ca2+ mobilization through activating phosphoinositide-specific phospholipase C (PI-PLC)-dependent inositol 1 ...
A. Cousson
doaj   +1 more source

IP3 receptors [PDF]

Current Biology, 2003
openaire   +3 more sources

Ang II-induced contraction is impaired in the aortas of renovascular hypertensive animal model

Vascular Biology
Renin–angiotensin system plays a critical role in blood pressure control, and the abnormal activation of the AT1 receptor contributes to the development of renovascular hypertension.
Bernah M Fahning, Simone R Potje, Tiago D Paula, Marcella D Grando, Lusiane M Bendhack   +4 more
doaj   +1 more source