Results 51 to 60 of about 1,266,606 (191)
Communicative & Integrative Biology, 2010 Autosomal dominant polycystic kidney disease (ADPKD) arises as a consequence of mutations of the genes PKD1 and PKD2, encoding respectively the integral membrane proteins polycystin-1 and polycystin-2 (TRPP2), resulting in a disturbance in intracellular ...
Eva Sammels +6 more
doaj +1 more source
Non-inositol 1,4,5-trisphosphate (IP3) receptor IP3-binding proteins
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023 Conventionally, myo-D-inositol 1, 4,5-trisphosphate (IP3) is thought to exert its second messenger effects through the gating of IP3R Ca2+ release channels, located in Ca2+-storage organelles like the endoplasmic reticulum. However, there is considerable indirect evidence to support the concept that IP3 might interact with other, non-IP3R proteins ...
openaire +2 more sources
The IP3 receptor–mitochondria connection in apoptosis and autophagy [PDF]
, 2011 The amount of Ca2+ taken up in the mitochondrial matrix is a crucial determinant of cell fate; it plays a decisive role in the choice of the cell between life and death. The Ca2+ ions mainly originate from the inositol 1,4,5-trisphosphate (IP3)-sensitive
Monaco, Giovanni +11 more
core +1 more source
Nature Communications, 2022 The formation and dissolution of ER-Mitochondria contacts is unclear. Here, authors show that the IP3 receptor traffics in and out of the contacts and, when trapped, improves calcium signaling to stimulate energy metabolism.
Máté Katona +9 more
doaj +1 more source
Identification of type 1 IP3 receptors in the rat kidney and their modulation by immobilization stress [PDF]
, 2000 Inositol 1,4,5-trisphosphate receptor (IP3-receptor) is a calcium channel, transporting calcium from intracellular stores to the cytoplasm. In kidney, IP3-receptors are involved in the signal transduction of various hormones.
Žáčiková, Ľ. +7 more
core +1 more source
MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis
Stem Cell Reports, 2019 Summary: Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant strategy for preventing age-related cognitive decline in humans. The underlying mechanisms remains controversial.
Meritxell Pons-Espinal +10 more
doaj +1 more source
eLife, 2020 The ‘building-block’ model of inositol trisphosphate (IP3)-mediated Ca2+ liberation posits that cell-wide cytosolic Ca2+ signals arise through coordinated activation of localized Ca2+ puffs generated by stationary clusters of IP3 receptors (IP3Rs). Here,
Jeffrey T Lock, Ian Parker
doaj +1 more source
Cell Reports, 2019 Summary: Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from the
Eugen Brailoiu +8 more
doaj +1 more source
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes [PDF]
, 2010 Intracellular calcium levels ([Ca2+]i) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied.
A. E. Contreras-Ferrat +10 more
core +2 more sources
Simulation of IP3 receptor function in cerebellar Purkinje cell dendritic spine: Importance of stochasticity [PDF]
, 2007 Background and aims: This thesis investigates calcium dynamics in cerebellar Purkinje cells. A special emphasis is put on the Purkinje cells dendritic spines where most of the synapses are formed.
HITURI, KATRI
core