Results 31 to 40 of about 1,266,606 (191)

Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia

Nature Communications, 2019
Disturbances in IP3 receptor-mediated release of Ca2+ from the endoplasmatic reticulum are associated with neurodegenerative disease. Here, the authors identify in four families with hereditary spastic paraplegia biallelic mutations in RNF170 that ...
Matias Wagner, Daniel P. S. Osborn, Ina Gehweiler, Maike Nagel, Ulrike Ulmer, Somayeh Bakhtiari, Rim Amouri, Reza Boostani, Faycal Hentati, Maryam M. Hockley, Benedikt Hölbling, Thomas Schwarzmayr, Ehsan Ghayoor Karimiani, Christoph Kernstock, Reza Maroofian, Wolfgang Müller-Felber, Ege Ozkan, Sergio Padilla-Lopez, Selina Reich, Jennifer Reichbauer, Hossein Darvish, Neda Shahmohammadibeni, Abbas Tafakhori, Katharina Vill, Stephan Zuchner, Michael C. Kruer, Juliane Winkelmann, Yalda Jamshidi, Rebecca Schüle   +28 more
doaj   +1 more source

Phospholipase C-β1 and β4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. [PDF]

PLoS ONE, 2014
A uniform extracellular stimulus triggers cell-specific patterns of Ca(2+) signals, even in genetically identical cell populations. However, the underlying mechanism that generates the cell-to-cell variability remains unknown.
Sachiko Ishida, Toru Matsu-Ura, Kiyoko Fukami, Takayuki Michikawa, Katsuhiko Mikoshiba   +4 more
doaj   +1 more source

Changes in IP3 Receptor Expression and Function in Aortic Smooth Muscle of Atherosclerotic Mice. [PDF]

J Vasc Res, 2017
Peroxynitrite is an endothelium - independent vasodilator which induces relaxation via membrane hyperpolarisation. A ctivation of IP3 receptors triggers opening of potassium channels and hyperpolarisation.
Ewart MA, Ugusman A, Vishwanath A, Almabrouk TAM, Alganga H, Katwan OJ, Hubanova P, Currie S, Kennedy S.   +8 more
europepmc   +4 more sources

Loss of INPP5K attenuates IP3-induced Ca2+ responses in the glioblastoma cell line U-251 MG cells

BBA Advances, 2023
INPP5K (inositol polyphosphate 5-phosphatase K) is an endoplasmic reticulum (ER)-resident enzyme that acts as a phosphoinositide (PI) 5-phosphatase, capable of dephosphorylating various PIs including PI 4,5-bisphosphate (PI(4,5)P2), a key ...
Jens Loncke, Tomas Luyten, Ana Raquel Ramos, Christophe Erneux, Geert Bultynck   +4 more
doaj   +1 more source

IP3 receptor in the hair cells of frog semicircular canal and its possible functional role.

, 2006
The presence and functional role of inositol trisphosphate receptors (IP3R) was investigated by electrophysiology and immunohistochemistry in hair cells from the frog semicircular canal.
FARINELLI F, FESCE, RICCARDO GIUSEPPE, MARTINI, Marta, RUSSO G, GIOGLIO L, RISPOLI, Giorgio, PRIGIONI I, FESCE R., FARINELLI, Federica, RISPOLI G, MARTINI M, ROSSI, Marialisa, RUBBINI, Gemma, RUBBINI G, ROSSI M. L.   +14 more
core   +2 more sources

Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning

Cell Reports, 2018
Summary: Stressful events rapidly trigger activity-dependent synaptic plasticity, driving the formation of aversive memories. However, it remains unclear how stressful experience affects plasticity mechanisms to regulate appetitive learning, such as ...
Jorge Tovar-Díaz, Matthew B. Pomrenze, Russell Kan, Bahram Pahlavan, Hitoshi Morikawa   +4 more
doaj   +1 more source

Calcium signalling: How do IP3 receptors work? [PDF]

, 1997
The intracellular receptor for inositol 1,4,5-trisphosphate (IP3) is responsible for generation and control of very complex Ca2+ signals. New experimental approaches to studying the kinetics of the IP3 receptor are now beginning to give some insight into
Dawson, Alan P
core   +1 more source

Anti-leptin receptor antibody mimics the stimulation of lipolysis induced by leptin in isolated mouse fat pads

Journal of Lipid Research, 2001
An anti-leptin receptor polyclonal antibody (receptor antibody), as well as leptin, stimulated the release of free fatty acids from isolated mouse fat pads in a time-dependent manner.
Natsuyo Kawaji, Aya Yoshida, Toshio Motoyashiki, Tetsuo Morita, Hiroshi Ueki   +4 more
doaj   +1 more source

GUANYLYL CYCLASE/NATRIURETIC PEPTIDES RECEPTOR-A SIGNALING ANTAGONIZES PHOSPHOINOSITIDE HYDROLYSIS, Ca2+ RELEASE, AND ACTIVATION OF PROTEIN KINASE C

Frontiers in Molecular Neuroscience, 2014
Thus far, three related natriuretic peptides (NPs) and three distinct sub-types of cognate NP receptors have been identified and characterized based on the specific ligand binding affinities, guanylyl cyclase activity, and generation of intracellular ...
Kailash N Pandey
doaj   +1 more source

IP3 receptors and Ca2+ entry

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019
Inositol 1,4,5-trisphosphate receptors (IP3R) are the most widely expressed intracellular Ca2+ release channels. Their activation by IP3 and Ca2+ allows Ca2+ to pass rapidly from the ER lumen to the cytosol. The resulting increase in cytosolic [Ca2+] may directly regulate cytosolic effectors or fuel Ca2+ uptake by other organelles, while the decrease ...
Taylor, CW, Thillaiappan, N, Hasan, Gaiti, Pragnya, Chakraborty   +3 more
openaire   +3 more sources