Results 21 to 30 of about 1,266,606 (191)
Measurement of Inositol Triphosphate Levels from Rat Hippocampal Slices
Bio-Protocol, 2016 Inositol triphosphate (IP3) is an important second messenger that participates in signal transduction pathways in diverse cell types including hippocampal neurons.
Nino Tabatadze, Catherine Woolley
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Disruption of the IP3 receptor gene of Drosophila affects larval metamorphosis and ecdysone release [PDF]
, 1997 Background: The inositol 1,4,5-trisphosphate (IP3) receptor is an intracellular calcium channel that couples cell membrane receptors, via the second messenger IP3, to calcium signal transduction pathways within many types of cells.
Hasan, G., Venkatesh, K.
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IP3 receptors and their intimate liaisons [PDF]
Current Opinion in Physiology, 2020 Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. They allow cell-surface receptors that stimulate IP3 formation to evoke rapid Ca2+ release from the endoplasmic reticulum (ER). IP3Rs initiate local and global cytosolic Ca2+ signals, they deliver Ca2+ selectively to other organelles including mitochondria and lysosomes ...
Peace, Atakpa-Adaji +2 more
openaire +3 more sources
Cell Reports, 2016 Dopamine action in the nucleus accumbens (NAc) is thought to drive appetitive behavior and Pavlovian reward learning. However, it remains controversial how dopamine achieves these behavioral effects by regulating medium spiny projection neurons (MSNs) of
Immani Swapna +2 more
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Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity [PDF]
, 1997 Background: Ca2+ waves allow effective delivery of intracellular Ca2+ signals to cytosolic targets. Propagation of these regenerative Ca2+ signals probably results from the activation of intracellular Ca2+ channels by the increase in cytosolic [Ca2 ...
Taylor, Colin W., Marchant, Jonathan S.
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IRBIT, a Novel Inositol 1,4,5-Trisphosphate (IP3) Receptor-binding Protein, Is Released from the IP3 Receptor upon IP3 Binding to the Receptor [PDF]
Journal of Biological Chemistry, 2003 The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are IP(3)-gated Ca(2+) channels on intracellular Ca(2+) stores. Herein, we report a novel protein, termed IRBIT (IP(3)R binding protein released with inositol 1,4,5-trisphosphate), which interacts with type 1 IP(3)R (IP(3)R1) and was released upon IP(3) binding to IP(3)R1.
Hideaki, Ando +3 more
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Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation [PDF]
, 2019 Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located similar to 100 angstrom away from the IP3-binding core (IBC).
Chandran, Aneesh +3 more
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, 2003 Hyaluronan ((HA)---a major extracellular matrix component) and its membrane binding protein, CD44, are important for aortic endothelium-related vascular integrity, barrier function and angiogenesis. HA binding to CD44 promotes signal transduction and the
Singleton, Patrick
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PLoS ONE, 2021 Alzheimer's disease (AD) is a devastating illness affecting over 40 million people worldwide. Intraneuronal rise of amyloid beta in its oligomeric forms (iAβOs), has been linked to the pathogenesis of AD by disrupting cytosolic Ca2+ homeostasis. However,
Joseph Minicucci +4 more
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Ethanol Disrupts Hormone-Induced Calcium Signaling in Liver
Function, 2021 Receptor-coupled phospholipase C (PLC) is an important target for the actions of ethanol. In the ex vivo perfused rat liver, concentrations of ethanol >100 mM were required to induce a rise in cytosolic calcium (Ca2+) suggesting that these responses may ...
Lawrence D Gaspers +3 more
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