Results 41 to 50 of about 1,266,606 (191)

Association of the hepatic IP3 receptor with the plasma membrane: relevance to mode of action

, 1993
Studies were carried out to characterize the interaction between inositol 1,4,5-trisphosphate (IP3) receptors and the plasma membrane fraction.
N. Kraus-Friedmann, L. Feng
core   +1 more source

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]

PLoS ONE, 2014
Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo, Stephen C Tovey, Colin W Taylor   +2 more
doaj   +1 more source

The Clustering of Inositol 1,4,5-Trisphosphate (IP3) Receptors Is Triggered by IP3 Binding and Facilitated by Depletion of the Ca2+ Store

Journal of Pharmacological Sciences, 2008
The inositol 1,4,5-trisphosphate receptors (IP3Rs) form clusters following agonist stimulation, but its mechanism remains controversial. In this study, we visualized the clustering of green fluorescent protein (GFP)-tagged type 3 IP3R (GFP-IP3R3) in ...
Yosuke Tojyo, Takao Morita, Akihiro Nezu, Akihiko Tanimura   +3 more
doaj   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Tatulian, L, Hughes, S, Brown, DA, Marsh, SJ, Winks, JS, Filippov, AK   +6 more
core  

The release of neurotrophic factor NPY following injury simulation is mediated by a purinergic receptor, phospholipase C, and IP3/IP3 receptor pathway.

, 2013
(A) P2X1,7 and P2Y2 receptors mediate NPY release. Neonatal OE slices from Swiss Webster mice were incubated with vehicle (0.2% DMSO), non-selective P2 purinergic receptor agonist (ATP, 50 µM), P2X1,7 agonist (BzATP, 50 µM), P2Y2,4,6 agonist (UTP, 50 µM)
Cuihong Jia (388816), Tania R. Iqbal (388819), Chelsea R. Hutch (388818), Sebastien Hayoz (388817), Apryl E. Pooley (388820), Colleen C. Hegg (388821)   +5 more
core   +1 more source

Visualization of IP3 Dynamics Reveals a Novel AMPA Receptor-Triggered IP3 Production Pathway Mediated by Voltage-Dependent Ca2+ Influx in Purkinje Cells [PDF]

, 2001
IP3 signaling in Purkinje cells is involved in the regulation of cell functions including LTD. We have used a GFP-tagged pleckstrin homology domain to visualize IP3 dynamics in Purkinje cells.
Iino, Masamitsu, Okubo, Yohei, Hirose, Kenzo, Kakizawa, Sho   +3 more
core   +1 more source

Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP3 receptor

Biophysics and Physicobiology, 2019
Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling. The structural basis of the gating in IP3R has been studied by X-ray crystallography and cryo-electron microscopy,
Kei Moritsugu, Tsubasa Ito, Akinori Kidera   +2 more
doaj   +1 more source

Octopamine regulates antennal sensory neurons via daytime-dependent changes in cAMP and IP3 levels in the hawkmoth Manduca sexta. [PDF]

PLoS ONE, 2015
The biogenic amine octopamine (OA) mediates reward signals in olfactory learning and memory as well as circadian rhythms of sleep and activity. In the crepuscular hawkmoth Manduca sexta, OA changed pheromone detection thresholds daytime-dependently ...
Thomas Schendzielorz, Katja Schirmer, Paul Stolte, Monika Stengl   +3 more
doaj   +1 more source

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]

, 2004
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Arnoult, Christophe, Cristiano Grasso, Treves, Susan, Ronjat, Michel, Mikoshiba, Katsuhiko, ARNOULT C, GRASSO C, TREVES, Susan Nella, Ducreux, Sylvie, DUCREUX S, Smida-Rezgui, Sophia, Franzini-Armstrong, Clara, MIKOSHIBA K, SCHRUM A, Sylvie Ducreux, Susan Treves, RONJAT M, Grasso, Cristiano, Zhu, Michael X., Zorzato, Francesco, SMIDA REZGUI S, Sophia Smida-Rezgui, MOCCAGATTA L, Zhu, Michael, Francesco Zorzato, Clara Franzini-Armstrong, Christophe Arnoult, Luca Moccagatta, Schrum, Adam, Michel Ronjat, ZHU MX, GIRARD T, Girard, Thierry, Katsuhiko Mikoshiba, Thierry Girard, FRANZINI ARMSTRONG C, Moccagatta, Luca, Michael X. Zhu, Adam Schrum   +38 more
core   +1 more source

An IP3R3- and NPY-expressing microvillous cell mediates tissue homeostasis and regeneration in the mouse olfactory epithelium. [PDF]

PLoS ONE, 2013
Calcium-dependent release of neurotrophic factors plays an important role in the maintenance of neurons, yet the release mechanisms are understudied. The inositol triphosphate (IP3) receptor is a calcium release channel that has a physiological role in ...
Cuihong Jia, Sebastien Hayoz, Chelsea R Hutch, Tania R Iqbal, Apryl E Pooley, Colleen C Hegg   +5 more
doaj   +1 more source