Results 61 to 70 of about 1,266,606 (191)

An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum.

PLoS Genetics
Calcium release from intracellular stores influences synaptic response timing and magnitude. Despite the critical role of inositol trisphosphate (IP3)- and ryanodine receptor (RyR)-dependent calcium release in regulating synaptic strength, the upstream ...
Bhagaban Mallik, Shikha Kushwaha, Anjali Bisht, Harsha Mj, C Andrew Frank, Vimlesh Kumar   +5 more
doaj   +1 more source

IP3 receptor signaling and endothelial barrier function [PDF]

Cellular and Molecular Life Sciences, 2017
The endothelium, a monolayer of endothelial cells lining vessel walls, maintains tissue-fluid homeostasis by restricting the passage of the plasma proteins and blood cells into the interstitium. The ion Ca2+, a ubiquitous secondary messenger, initiates signal transduction events in endothelial cells that is critical to control of vascular tone and ...
Mitchell Y, Sun, Melissa, Geyer, Yulia A, Komarova   +2 more
openaire   +2 more sources

Different roles of IP4 and IP3 in the signal pathway coupled to the TRH receptor in microinjected Xenopus oocytes [PDF]

, 1989
Different effects of injected IP4 and IP3, on membrane Cl− currents were observed in Xenopus oocytes previously microinjected with GH3, cell poly(A)+ RNA.
Wolfgang Meyerhof, Meyerhof, Wolfgang, Stefan Mahlmann, Jürgen R. Schwarz, Mahlmann, Stefan, Schwarz, Jürgen R.   +5 more
core   +1 more source

IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells

, 2005
Smooth muscle responds to IP3-generating (sarcolemma acting) neurotransmitters and hormones by releasing Ca2+ from the sarcoplasmic reticulum (SR) via IP3 receptors (IP3Rs). This release may propagate as Ca2+ waves.
Muir, T.C., Susan Chalmers, Chalmers, S., MacMillan, D., McCarron, J.G., Debbi MacMillan, Thomas C. Muir, John G. McCarron   +7 more
core   +4 more sources

Expression of mRNAs for different types of IP3 receptors in rat kidneys

, 1995
Cloning studies have extensively characterized two types of inositol 1,4,5-trisphosphate (IP3) receptors from the rat. An IP3 receptor from the cerebellum is referred to as type 1, and a second, recently described, receptor is referred to as the type 2 ...
T. Yang, K. Tomita, F. Marumo, H. Nonoguchi, Y. Terada   +4 more
core   +1 more source

Single-channel recording of inositol trisphosphate receptor in the isolated nucleus of a muscle cell line

Biological Research, 2006
Nuclear calcium appears to have an important role in the regulation of gene expression in many cells, but the mechanisms involved in controlling nuclear Ca2+ signaling are controversial and still poorly understood.
CARLOS KUSNIER, CÉSAR CÁRDENAS, JORGE HIDALGO, ENRIQUE JAIMOVICH   +3 more
doaj  

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

eLife, 2016
IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.
Benjamin Bonneau, Hideaki Ando, Katsuhiro Kawaai, Matsumi Hirose, Hiromi Takahashi-Iwanaga, Katsuhiko Mikoshiba   +5 more
doaj   +1 more source

Circulating IgGs in Type 2 Diabetes with Atrial Fibrillation Induce IP3-Mediated Calcium Elevation in Cardiomyocytes

iScience, 2020
Summary: Higher risk of cardiac arrhythmias including atrial fibrillation (AF) associates with type 2 diabetes mellitus (T2DM) with the underlying mechanism largely unknown.
Yanhong Luo, Xian Liu, Ruilian Ma, Yigang Wang, Mark Zimering, Zui Pan   +5 more
doaj   +1 more source

Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming [PDF]

, 2017
Hyperalgesic priming, a model of pain chronification in the rat, is mediated by ryanodine receptor-dependent calcium release. Although ryanodine induces priming in both sexes, females are 5 orders of magnitude more sensitive, by an estrogen receptor α ...
Ferrari, Luiz F, Khomula, Eugen V, Araldi, Dionéia, Levine, Jon D   +3 more
core   +1 more source

Inositol hexakisphosphate (IP6) enhances the electrical excitability of Characean Nitellopsis obtusa

Plant Stress
Despite the importance of action potentials (APs) in plant stress physiology, the molecular identity of Ca2+ channels that initiate APs by passing Ca2+ into the cytoplasm is still unknown in Characean macroalgae. While the Thiel-Beilby mathematical model
Vilmantas Pupkis, Judita Janužaitė, Indrė Lapeikaitė, Vilma Kisnierienė   +3 more
doaj   +1 more source