Results 1 to 10 of about 31,223 (160)
The discovery and development of IP3 receptor modulators: an update [PDF]
Expert Opinion on Drug Discovery, 2021 Introduction: Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular calcium (Ca2+) release channels located on the endoplasmic/sarcoplasmic reticulum. The availability of the structure of the ligand-binding domain of IP3Rs has enabled the design of compatible ligands, but the limiting step remains their actual effectiveness in a biological ...
Jessica Gambardella +2 more
exaly +5 more sources
From IP3RPEP6 Inhibition of IP3 receptor channels to insights: do channel subunits collaborate or cooperate? [PDF]
Cellular and Molecular Life SciencesInositol 1,4,5-trisphosphate (IP3) receptor channels are intracellular ion channels activated by IP3 and provoking Ca2+ release from ER/SR stores, playing fundamental roles in various cell functions ranging from fertilization up to cell death control ...
Katja Witschas, Siyu Tao, Luc Leybaert
doaj +2 more sources
The IP3 receptor and Ca2+ signaling in trypanosomes [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021 Trypanosoma cruzi, and the T. brucei group of parasites cause neglected diseases that affect millions of people around the world. These unicellular microorganisms have complex life cycles involving an insect vector and a mammalian host. Both groups of pathogens possess an inositol 1,4,5-trisphosphate (IP3)/diacylglycerol (DAG) signaling pathway, and an
Roberto, Docampo, Guozhong, Huang
openaire +3 more sources
IP3 receptor orchestrates maladaptive vascular responses in heart failure [PDF]
The Journal of Clinical Investigation, 2022 Patients with heart failure (HF) have augmented vascular tone, which increases cardiac workload, impairing ventricular output and promoting further myocardial dysfunction. The molecular mechanisms underlying the maladaptive vascular responses observed in
Haikel Dridi +11 more
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IP3 Receptor-Dependent Cytoplasmic Ca2+ Signals Are Tightly Controlled by Cavβ3
Cell Reports, 2018 Summary: Voltage-gated calcium channels (Cavs) are major Ca2+ entry pathways in excitable cells. Their β subunits facilitate membrane trafficking of the channel’s ion-conducting α1 pore and modulate its gating properties. We report that one β subunit, β3,
Anouar Belkacemi +8 more
doaj +3 more sources
IRBIT Suppresses IP3 Receptor Activity by Competing with IP3 for the Common Binding Site on the IP3 Receptor [PDF]
Molecular Cell, 2006 The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are IP3-gated intracellular Ca2+ channels. We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3. In the present study, we showed that IRBIT suppresses the activation of IP3R by competing with IP3
Katsuhiko Mikoshiba +2 more
exaly +4 more sources
Current Research in Microbial Sciences, 2023 Intracellular Ca2+ mobilization induced by second messenger IP3 controls many cellular events in most of the eukaryotic groups. Despite the increasing evidence of IP3-induced Ca2+ in apicomplexan parasites like Plasmodium, responsible for malaria ...
Eduardo Alves +3 more
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Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3. [PDF]
PLoS ONE, 2013 Most animal cells express mixtures of the three subtypes of inositol 1,4,5-trisphosphate receptor (IP(3)R) encoded by vertebrate genomes. Activation of each subtype by different agonists has not hitherto been examined in cells expressing defined ...
Huma Saleem +5 more
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Serotonergic signals enhanced hamster sperm hyperactivation
The Journal of Reproduction and Development, 2021 In the present study, we investigated the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters. First, we examined the types of 5-HT receptors that regulate hyperactivation.
Chiyori SAKAMOTO +3 more
doaj +1 more source
Structural basis for activation and gating of IP3 receptors
Nature Communications, 2022 IP3 receptors are intracellular calcium channels involved in numerous signaling pathways. Here, the authors present the cryo-EM structures of type-3 IP3 receptors in multiple gating conformations, including the active state revealing the molecular ...
Emily A. Schmitz +2 more
doaj +1 more source