Results 11 to 20 of about 1,266,606 (191)
iScience, 2020 Summary: During neurodevelopment, the growth cone deciphers directional information from extracellular guidance cues presented as shallow concentration gradients via signal amplification.
Carmen Chan +8 more
doaj +1 more source
Chinese Journal of Physiology, 2021 Gamma-linolenic acid (GLA), a natural fatty acid obtained from oils of various vegetables and seeds, has been demonstrated as an anticancer agent. In this work, we investigated the anticancer effects of GLA on breast cancer BT-474 cells.
Cing-Yu Chen +6 more
doaj +1 more source
A mathematical model of calcium dynamics in HSY cells. [PDF]
PLoS Computational Biology, 2017 Saliva is an essential part of activities such as speaking, masticating and swallowing. Enzymes in salivary fluid protect teeth and gums from infectious diseases, and also initiate the digestion process. Intracellular calcium (Ca2+) plays a critical role
Jung Min Han +3 more
doaj +1 more source
iScience, 2020 Summary: Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.
Paula J. Bartlett +3 more
doaj +1 more source
Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]
, 1991 Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
M. Gratzl +9 more
core +1 more source
Cell Reports, 2014 Receptor-mediated oscillations in cytosolic Ca2+ concentration ([Ca2+]i) could originate either directly from an autonomous Ca2+ feedback oscillator at the inositol 1,4,5-trisphosphate (IP3) receptor or as a secondary consequence of IP3 oscillations ...
Lawrence D. Gaspers +8 more
doaj +1 more source
eLife, 2023 Loss of endoplasmic reticular (ER) Ca2+ activates store-operated Ca2+ entry (SOCE) by causing the ER localized Ca2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS).
Pragnya Chakraborty +7 more
doaj +1 more source
Dynamic regulation of IP3 receptor clustering and activity by IP3 [PDF]
Channels, 2009 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are intracellular Ca(2+) channels. Their regulation by both IP(3) and Ca(2+) allows interactions between IP(3)Rs to generate a hierarchy of intracellular Ca(2+) release events. These can progress from openings of single IP(3)R, through near-synchronous opening of a few IP(3)Rs within a cluster to much ...
Taufiq, Rahman, Colin W, Taylor
openaire +2 more sources
Structural insights into the regulatory mechanism of IP3 receptor [PDF]
, 2004 Inositol 1,4,5-trisphosphate receptors (IP3R) are intracellular Ca2+ release channels whose opening requires binding of two intracellular messengers IP3 and Ca2+.
Mitsuhiko Ikura +7 more
core +1 more source
, 2022 Alcohol-related liver fibrosis (ALF) is a form of alcohol-related liver disease (ALD) that generally occurs in response to heavy long-term drinking. Ecto-5′-nucleotidase (NT5E), also known as CD73, is a cytomembrane protein linked to the cell membrane ...
Mengda Zhang (12882494) +11 more
core +1 more source