Results 181 to 190 of about 5,753 (209)

In vitro and in vivo safety testing of mycotoxin detoxifying agents [PDF]

open access: yes, 2012
Croubels, Siska   +6 more
core   +1 more source

Zearalenone induces ROS‐mediated mitochondrial damage in porcine IPEC‐J2 cells

Journal of Biochemical and Molecular Toxicology, 2017
AbstractIn this study, the mitochondrial damage effect and mechanism of zearalenone (ZEA) in swine small intestine IPEC‐J2 cells in vitro were comprehensively characterized. The analyses revealed that ZEA at high doses (8 and 7 μg/mL) can significantly increase P < 0.05 the malondialdehyde levels and decrease antioxidant enzymes activities after 48 ...
Wentao Fan   +7 more
openaire   +4 more sources

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production

Environmental Pollution, 2019
Deoxynivalenol (DON) frequently detected in a wide range of foods and feeds, inducing cytotoxicity to animals and humans. To investigate the underlying mechanism of DON-induced apoptosis and inflammation in porcine small intestinal epithelium, intestinal porcine epithelial cells (IPEC-J2 cells) were chosen as objects, and were treated by different ...
Ruifen, Kang   +5 more
openaire   +4 more sources

Transcriptional profiling of zearalenone-induced inhibition of IPEC-J2 cell proliferation

Toxicon, 2019
Mounting evidence has shown that zearalenone (ZEA) can have toxic effects on the intestinal epithelial cells (IECs) of mammals and humans, but the mechanism of ZEA-induced toxicity on IECs is unclear. The aim of this study was to reveal the mechanism of action of ZEA on intestinal epithelial cells via RNA-seq technology.
Xin Wang   +10 more
openaire   +2 more sources

NLRP9 involved in antiviral innate immunity via binding VIM in IPEC-J2 cells

Developmental & Comparative Immunology, 2023
Nucleotide-binding oligomerization domain (NOD)-like receptors with a pyrin domain (PYD)-containing protein 9 (NLRP9) was the first nucleotide-binding region receptor (NLR) proposed to be expressed and function only in the reproductive system. Recent evidence suggests that NLRP9 is also capable of playing a role in infectious and inflammatory diseases ...
Ge, Qin   +6 more
openaire   +2 more sources

The Effects of Lauric Acid on IPEC-J2 Cell Differentiation, Proliferation, and Death

Current Molecular Medicine, 2020
Background: Lauric acid (LA) has antimicrobial effects and the potential to replace antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The effects of lauric acid on the intestinal epithelial cells remain unclear.
Yuan, Yang   +4 more
openaire   +2 more sources

Potassium diformate alleviated inflammation of IPEC-J2 cells infected with EHEC

Veterinary Microbiology
Potassium diformate (KDF) is a kind of formate, which possesses the advantages of antimicrobial activity, growth promotion and preventing diarrhea in weaned piglets. However, the researches of KDF in animal production mostly focused on apparent indexes such as growth performance and the mechanisms of KDF on intestinal health have not been reported ...
Ying, Lin   +7 more
openaire   +2 more sources

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