The Inflammatory Response to Enterotoxigenic E. coli and Probiotic E. faecium in a Coculture Model of Porcine Intestinal Epithelial and Dendritic Cells [PDF]
Mediators of Inflammation, 2018 The gut epithelium constitutes an interface between the intestinal contents and the underlying gut-associated lymphoid tissue (GALT) including dendritic cells (DC).
Henriette Loss +4 more
doaj +2 more sources
The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells [PDF]
Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2021 The porcine intestinal epithelial cell line IPEC-J2 cells, which were isolated from neonatal piglet mid-jejunum, the main components of the intestinal epithelium and play an important role in the intestine.
Xueqin Zhao
doaj +3 more sources
IPEC-J2 as a cellular model for studying intestinal mucus [PDF]
Scientific ReportsMucus in the proximal small intestine serves critical protective and transport functions, regulating nutrient absorption to enterocytes. The porcine jejunal epithelial cell line IPEC-J2 is widely used to study epithelial barrier function, yet its ...
Frédéric Dessauge +7 more
doaj +2 more sources
Inhibition of Enterotoxigenic Escherichia coli adhesion via aptamers prevents infection in IPEC-J2 cells [PDF]
BMC MicrobiologyEnterotoxigenic Escherichia coli (ETEC) is a well-known strain associated with post-weaning diarrhea. Consequently, strategies to prevent and inhibit ETEC infections are critically important. Aptamers are single-stranded DNA or RNA sequences that exhibit
Zefeng Wang +5 more
doaj +2 more sources
Luteolin attenuates LPS-induced damage in IPEC-J2 cells by enhancing mitophagy via AMPK signaling pathway activation [PDF]
Frontiers in NutritionBackgroundLuteolin (LUT), a flavonoid compound widely present in natural plants, has been extensively studied for its diverse biological properties, involving anti-inflammatory,antioxidant, anti-apoptosis and other properties.MethodsThe aim of this study
Jianyun Yuan +10 more
doaj +2 more sources
Protective effects of Curcumin-Zinc complex on inflammatory damage of IPEC-J2 cells induced by bacterial lipopolysaccharide [PDF]
AMB ExpressThe present study aimed to investigate the potential mitigative effects of the Curcumin-Zinc Complex (Cur-Zn) on bacterial lipopolysaccharide (LPS)-induced inflammatory damage in porcine small intestinal epithelial cells (IPEC-J2).
Xiaopeng Tang, Yan Zeng, Meijun Li
doaj +2 more sources
Comparative evaluation of the modulatory role of 1,25-dihydroxy-vitamin D3 on endoplasmic reticulum stress-induced effects in 2D and 3D cultures of the intestinal porcine epithelial cell line IPEC-J2 [PDF]
Journal of Animal Science and BiotechnologyBackground The use of conventional two-dimensional (2D) culture of the porcine intestinal epithelial cell (IEC) line IPEC-J2 in animal nutrition research has the disadvantage that IEC function is studied under unphysiological conditions, which limits the
Gaiping Wen, Klaus Eder, Robert Ringseis
doaj +2 more sources
IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes [PDF]
Pharmaceutics, 2020 The efflux pump P-glycoprotein (P-gp) affects drug distribution after absorption in humans and animals. P-gp is encoded by the multidrug resistance gene (MDR1) gene in humans, while rodents (the most common preclinical animal model) express the two ...
Lasse Saaby +4 more
doaj +3 more sources
Toxins, 2023 Aflatoxin B1 (AFB1), a typical fungal toxin found in feed, is highly carcinogenic. Oxidative stress is one of the main ways it exerts its toxicity; therefore, finding a suitable antioxidant is the key to reducing its toxicity.
Yue Tian +8 more
doaj +3 more sources
Unraveling the pathogenic potential of the Pentatrichomonas hominis PHGD strain: impact on IPEC-J2 cell growth, adhesion, and gene expression [PDF]
ParasitePentatrichomonas hominis, a flagellated parasitic protozoan, predominantly infects the mammalian digestive tract, often causing symptoms such as abdominal pain and diarrhea. However, studies investigating its pathogenicity are limited, and the mechanisms
Zhu Yibin +16 more
doaj +2 more sources