Results 31 to 40 of about 5,777 (211)

The tissue expression level of BPI gene in piglets from newborn to weaning and its relationship with Gram-negative bacterial infection

Journal of Integrative Agriculture, 2020
The bactericidal/permeability increasing protein (BPI) has an important function of nonspecific killing of Gram-negative bacteria. In this study, qPCR was used to detect the expression of the BPI gene in twelve tissues of Meishan piglets from birth to ...
Chao-hui DAI, Yue CAO, Zhong-cheng GAO, Guo-qiang ZHU, Sheng-long WU, Wen-bin BAO   +5 more
doaj   +1 more source

All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Apoptosis in IPEC-J2 Cells via Inhibiting ROS-Mediated P₃₈MAPK Signaling Pathway

Antioxidants, 2022
Transmissible gastroenteritis virus (TGEV) can cause diarrhea, dehydration, and high mortality in piglets, which is closely related to intestinal epithelial cell apoptosis caused by TGEV infection.
Junning Pu, Daiwen Chen, Gang Tian, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Bing Yu   +11 more
doaj   +1 more source

Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium against Clostridioides (syn. Clostridium) difficile Toxin-Induced Effects [PDF]

, 2020
Clostridioides difficile toxins are one of the main causative agents for the clinical symptoms observed during C. difficile infection in piglets. Porcine milk has been shown to strengthen the epithelial barrier function in the piglet’s intestine and may ...
Grześkowiak, Łukasz, Hauser, Anja E., Kröger, Susan, Martínez-Vallespín, Beatriz, Niesner, Raluca, Pieper, Robert, Vahjen, Wilfried, Zentek, Jürgen   +7 more
core   +1 more source

lnc001776 Affects CPB2 Toxin-Induced Excessive Injury of Porcine Intestinal Epithelial Cells via Activating JNK/NF-kB Pathway through ssc-let-7i-5p/IL-6 Axis

Cells, 2023
Piglet diarrhea caused by Clostridium perfringens (C. perfringens) type C (CpC) seriously endangers the development of the pig production industry. C. perfringens beta2 (CPB2) toxin is a virulent toxin produced by CpC.
Kaihui Xie, Zunqiang Yan, Qiaoli Yang, Xiaoyu Huang, Pengfei Wang, Xiaoli Gao, Jie Li, Shuangbao Gun   +7 more
doaj   +1 more source

Integrins Were Involved in Soybean Agglutinin Induced Cell Apoptosis in IPEC-J2 [PDF]

International Journal of Molecular Sciences, 2018
Abstract: Soybean agglutinin (SBA), is a non-fiber carbohydrate related protein and a major anti-nutritional factor. Integrins, transmembrane glycoproteins, are involved in many biological processes. Although recent work suggested that integrins are involved in SBA-induced cell-cycle alterations, no comprehensive study has reported whether integrins ...
Li Pan, Yuan Zhao, Mohammed Hamdy Farouk, Nan Bao, Tao Wang, Guixin Qin   +5 more
openaire   +2 more sources

β-defensin 118 attenuates inflammation and injury of intestinal epithelial cells upon enterotoxigenic Escherichia coli challenge

BMC Veterinary Research, 2022
Background Antimicrobial peptides including various defensins have been attracting considerable research interest worldwide, as they have potential to substitute for antibiotics. Moreover, AMPs also have immunomodulatory activity.
Qingqing Fu, Qian Lin, Daiwen Chen, Bing Yu, Yuheng Luo, Ping Zheng, Xiangbing Mao, Zhiqing Huang, Jie Yu, Junqiu Luo, Hui Yan, Jun He   +11 more
doaj   +1 more source

TGF-β from the Porcine Intestinal Cell Line IPEC-J2 Induced by Porcine Circovirus 2 Increases the Frequency of Treg Cells via the Activation of ERK (in CD4⁺ T Cells) and NF-κB (in IPEC-J2)

Viruses, 2022
Porcine circovirus 2 (PCV2) causes immunosuppression. Piglets infected with PCV2 can develop enteritis. Given that the gut is the largest immune organ, however, the response of the gut’s immune system to PCV2 is still unclear.
Xuewei Liu, Yang Wang, Cheng Han, Qiuming Li, Xiaolin Hou, Qinye Song, Shuanghai Zhou, Huanrong Li   +7 more
doaj   +1 more source

Activation of the JNK/MAPK Signaling Pathway by TGF-β1 Enhances Neonatal Fc Receptor Expression and IgG Transcytosis

Microorganisms, 2021
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the foetus or newborn and protects the IgG from degradation. FcRn is expressed in several porcine tissues and cell types and its expression levels are regulated by immune and ...
Shaoju Qian, Chenxi Li, Xi Liu, Xiangchao Jia, Yuncai Xiao, Zili Li   +5 more
doaj   +1 more source

Gene Expression Analysis of the IPEC-J2 Cell Line: A Simple Model for the Inflammation-Sensitive Preterm Intestine [PDF]

, 2013
The IPEC-J2 cell line was studied as a simple model for investigating responses of the newborn intestinal epithelium to diets. Especially, the small intestine of immature newborns is sensitive to diet-induced inflammation. We investigated gene expression
Heegaard, Peter M. H., Sangild, Per T., Skovgaard, Kerstin, Støy, Ann Cathrine Findal, Østergaard, Mette V.   +4 more
core   +4 more sources

Profiling of alternative polyadenylation and gene expression in PEDV-infected IPEC-J2 cells [PDF]

Virus Genes, 2021
Since 2010, porcine epidemic diarrhea virus (PEDV) has received global attention with the emergence of variant strains characterized with high pathogenicity. The pathogen-host interaction after PEDV infection is still unclear. To investigate this issue, high-throughput-based sequencing technology is one of the optimal choices. In this study, we used in
Xiaona Wei, Jie Li, Yun Zhang, Lang Gong, Chunyi Xue, Yongchang Cao   +5 more
openaire   +2 more sources