Results 221 to 230 of about 104,261 (287)

Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia.

JAMA Psychiatry
Raabe FJ, Popovic D, Vetter C, Fischer LE, Hasanaj G, Karsli B, Schäfer TJ, Almeida V, Atella A, Gagliardi M, Boudriot E, Yakimov V, Trastulla L, Jiang T, Weyer C, Roell L, Moussiopoulou J, Krcmár L, Galinski S, Papazova I, Pogarell O, Hasan A, Schulte EC, Schmitt A, Koutsouleris N, Levina A, Wagner E, Rossner MJ, Papiol S, Falkai P, Keeser D, Ziller MJ, CDP Working Group.   +32 more
europepmc   +1 more source

CR2-fH, A Targeted Inhibitor of Alternative Complement Pathway Reduces Dry AMD-Like Phenotype in AMD Patient iPSC-derived RPE Cells. [PDF]

Invest Ophthalmol Vis Sci
Navneet S, Rohrer B.
europepmc   +1 more source

Metformin and reprogramming into iPSCs [PDF]

Cell Cycle, 2012
openaire   +2 more sources

RBFOX1 Dysfunction Unlocks APOE4‐Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids

Exploration, EarlyView.
Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9‐mediated RBFOX1 loss in APOE4 human cerebral organoids induces autonomous microglial genesis and accelerates AD pathology, revealing a protective role of RBFOX1 and establishing a model ...
Bowen Zhang, Changjie Shi, Jiayi Zhao, Qiuhong Hua, Houchun Zhang, Hailin Gao, Yuanyuan Qian, Jiaxue Cha, Jing Li, Jiayao Chen, Tae‐Hyung Kim, Jianhuang Xue, Yujun Hou, Ru Zhang   +13 more
wiley   +1 more source

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation. [PDF]

Elife
Pavel MA, Chen H, Hill M, Sridhar A, Barney M, DeSantiago J, Baskaran A, Owais A, Sandu S, Darbar FA, Ornelas Loredo A, Al-Azzam B, Chalazan B, Rehman J, Darbar D.   +14 more
europepmc   +1 more source

iPSCs: 10 Years and Counting [PDF]

Cell, 2016
openaire   +2 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders. [PDF]

Exp Dermatol
Salois MN, Webb S, Proctor IA, Koch PJ, Koster MI.   +4 more
europepmc   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, EarlyView.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

APP Deficiency Ameliorates FAD Presenilin 1 F105C and A246E Mutations-induced Mitochondrial Dysfunction in Human Cortical Neurons. [PDF]

Int J Biol Sci
Yen YH, Yuan F, Tang D, Luo JF, Ming C, Kang PJ, Su H, Chong CM, Zhang SC.   +8 more
europepmc   +1 more source