Molecular Therapy, 2011 The advent of induced pluripotent stem cell (iPSC) technology holds great promise to revolutionize personalized cell-based therapies.1,2,3,4,5 Recent advances in gene transfer technology therefore open up exciting possibilities for efficient and safe genetic modification of autologous cells in this context.6 As potential therapeutic applications are ...
Mukherjee, Sayandip, Thrasher, Adrian J
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Copy number variations in healthy subjects. Case study: iPSC line CSSi005-A (3544) production from an individual with variation in 15q13.3 chromosome duplicating gene CHRNA7 [PDF]
, 2018 CHRNA7, encoding the neuronal alpha7 nicotinic acetylcholine receptor (a7nAChR), is highly expressed in the brain, particularly in the hippocampus. It is situated in the 15q13.3 chromosome region, frequently associated with a Copy Number Variation (CNV),
Altieri, Filomena +13 more
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Translational Neurodegeneration, 2023 Background Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly, resulting in gradual destruction of cognitive abilities.
Hyunkyung Mo +7 more
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Maturing iPSC-Derived Cardiomyocytes [PDF]
Cells, 2020 Cardiovascular disease is a major cause of mortality worldwide [...]
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Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. [PDF]
, 2019 The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease.
Aguiar +76 more
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Anti-fibrotic effect of a selective estrogen receptor modulator in systemic sclerosis
Stem Cell Research & Therapy, 2022 Background The rarity of systemic sclerosis (SSc) has hampered the development of therapies for this intractable autoimmune disease. Induced pluripotent stem cell (iPSC) can be differentiated into the key disease-affected cells in vitro.
Yena Kim +3 more
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Improving food security through the urban farming workshop for disaster risk reduction: evidence from Jogoyudan Village, Yogyakarta as a Resilient City [PDF]
E3S Web of Conferences, 2021 This study aims to determine the effect of the implementation of urban farming workshops on food security of Jogoyudan Village residents supporting the concept of Yogyakarta as a Resilient City as a disaster risk reduction.
Jalu Aji Lexi +4 more
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ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cells- derived motoneurons [PDF]
, 2015 Patient-derived induced Pluripotent Stem Cells (iPSCs) provide an opportunity to study human diseases mainly in those cases where no suitable model systems are available.
Bozzoni, Irene +9 more
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Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]
, 2017 Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H. +5 more
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DNA methylation patterns in human iPSC-derived sensory neuronal differentiation
Epigenetics, 2019 Sensory neurons of the peripheral nervous system are critical in health and disease. Sensory neurons derived from induced pluripotent stem (iPS) cells are now being used increasingly for in vitro models of neuropathy, pain, and neurotoxicity.
Soneela Ankam +13 more
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