DNA methylation patterns in human iPSC-derived sensory neuronal differentiation
Epigenetics, 2019 Sensory neurons of the peripheral nervous system are critical in health and disease. Sensory neurons derived from induced pluripotent stem (iPS) cells are now being used increasingly for in vitro models of neuropathy, pain, and neurotoxicity.
Soneela Ankam +13 more
doaj +1 more source
Disease Models & Mechanisms, 2019 Schimke immuno-osseous dysplasia is an autosomal recessive genetic osteochondrodysplasia characterized by dysmorphism, spondyloepiphyseal dysplasia, nephrotic syndrome and frequently T cell immunodeficiency.
Giusj Monia Pugliese +7 more
doaj +1 more source
Monitoring and analysis of seismic data during the 2018 sunda strait tsunami [PDF]
E3S Web of Conferences, 2021 The tsunami of Sunda Strait occurred on December 22, 2018, at 21:03 West Indonesia Time (zone). An eruption of Mount Anak Krakatau caused an eruption that triggered a landslide on the slopes of Mount Anak Krakatau covering an area of 64 hectares that hit
Kurniawan Wahyu +4 more
doaj +1 more source
Numerical investigation on the effect of blunt body deflector on darieus turbine performance [PDF]
E3S Web of ConferencesOne of the renewable energy source that is abundant but has not been used optimally is wind energy. Roads are currently the main transportation infrastructure along with the increasing number of motorized vehicles.
Rofi’i Ahmad Syafiq +5 more
doaj +1 more source
Development of an Arrhythmogenic Cardiomyopathy Model Using CRISPR-Cas9 and Homology-Directed Repair
Український журнал серцево-судинної хірургіїArrhythmogenic cardiomyopathy (ACM) frequently results from loss-of-function variants in PKP2, leading to desmosomal failure, electrical instability, and fibrofatty remodeling.
Svetlana M. Gramatiuk +5 more
doaj +1 more source
Hybrid integrated platform of PDMS microfluidics and silica capillary for effective CE and ESI-MS coupling [PDF]
, 2009 We present an effective hybrid integration of PDMS microfluidic devices and fused silica capillaries. These hybrid microfluidic integrated PDMS and silica capillary (iPSC) modules exhibit a novel architecture and method for leakage free CE sample ...
Dimov, Ivan Krastev +3 more
core +1 more source
Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage [PDF]
, 2018 Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before ...
Bernardini, Laura +12 more
core +6 more sources
Stem Cell Research & Therapy, 2018 Background Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo.
Yena Kim +6 more
doaj +1 more source
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]
, 2017 Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov +43 more
core +2 more sources
, 2023 Differentiation is the process where an unspecialized cell acquires cellular traits that allow it to perform specialized functions. Indeed, the actual potential of iPSCs rest in their direct differentiation to various types of somatic cells. In order to use iPSCs to treat disease or as research tools to study diseases, fully functioning specialized ...
openaire +2 more sources