Results 191 to 200 of about 7,342 (224)

Pulmonary surfactant protein A and surfactant lipids upregulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophages.

Am J Physiol Lung Cell Mol Physiol, 2012
Nguyen HA, Rajaram MV, Meyer DA, Schlesinger LS.   +3 more
europepmc   +1 more source

Dissection of MAPK and NF-κB p65 signaling dynamics underlying LPS tolerance in macrophages at the single-cell level. [PDF]

Biotechnol Rep (Amst)
Laosuk T, Kueanjinda P, Kimura H, Palaga T.   +3 more
europepmc   +1 more source

IRAK4 autophosphorylation functions as a molecular switch to regulate death domain assembly and Myddosome maturation

Taylor M, Srikanth N, Deliz-Aguirre R, Gola DK, Bilay M, Ziska E, Kelsall I, Kukathu Y.   +7 more
europepmc   +1 more source

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Identification and characterization of murine IRAK-M

Biochemical and Biophysical Research Communications, 2002
Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have ...
Michael U Martin
exaly   +3 more sources

Activator protein 1 promotes the transcriptional activation of IRAK-M

Biomedicine and Pharmacotherapy, 2016
Interleukin-1 receptor-associated kinase M (IRAK-M) is a well-known negative regulator for Toll-like receptor signaling, which can regulate immune homeostasis and tolerance in a number of pathological settings. However, the mechanism for IRAK-M regulation at transcriptional level remains largely unknown.
Jinjun Bian, Lulong Bo, Xiaoming Deng
exaly   +3 more sources

IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts

Inflammation, 2022
Lung fibroblasts play an important role in subepithelial fibrosis, one feature for airway remodeling. IL-1 receptor-associated kinase (IRAK)-M was shown to involve fibrosis formation in airways and lung through regulation of inflammatory responses. IRAK-M is expressed by lung fibroblasts, whether IRAK-M has direct impact on lung fibroblasts remains ...
Zheng, Z, Li, J, Cui, Y, Wang, W, Zhang, M, Zhang, Y, Bai, Y, Ying, S, Gao, G   +8 more
openaire   +3 more sources

Association Between Gene Polymorphisms of IRAK-M and the Susceptibility of Sepsis

Inflammation, 2013
The aim of this study was to explore the association between the single-nucleotide polymorphisms of interleukin-1 receptor-associated kinase-M (IRAK-M) gene and the susceptibility of sepsis. The allele frequency and genotype distribution of IRAK-M gene polymorphisms were assessed in 118 controls and 82 sepsis patients by semiquantitative polymerase ...
Gao-Hong, Dong, Jian-Ping, Gong, Jin-Zheng, Li, Yu-Hong, Luo, Zhen-Dong, Li, Pei-Zhi, Li, Kun, He   +6 more
openaire   +2 more sources

IRAK‐M in macrophages around septically and aseptically loosened hip implants

Journal of Biomedical Materials Research Part A, 2011
AbstractThe most common long‐term complication of joint arthroplasty is loosening, which is mediated by chronic inflammatory cytokines produced by macrophages stimulated by implant‐derived debris and eventually bacterial components adherent to such debris.
Yangchun, Zhang, Changhe, Hou, Shiming, Yu, Jianhong, Xiao, Ziji, Zhang, Qiyi, Zhai, Jianwei, Chen, Ziqing, Li, Xibao, Zhang, Matti, Lehto, Yrjö T, Konttinen, Puyi, Sheng   +11 more
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MECHANISMS OF PIN1 REGULATION OF IRAK-M STABILITY IN TLR/IL-1R SIGNALING AND STRUCTURE DETERMINATION OF IRAK-M DEATH DOMAIN

2018
Asthma is a chronic inflammatory sickness of the airways caused by environmental and genetic factors. The mechanisms of activation of the innate immunity signaling pathways that cause asthma are not fully understood yet. This study investigated the novel targets for the development of new asthma therapeutics.
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Identification, characterisation and preliminary functional analysis of IRAK-M in grass carp (Ctenopharyngodon idella)

Fish & Shellfish Immunology, 2019
Interleukin-1 receptor-associated kinase (IRAK) family members play important roles in myeloid differentiation primary response 88 (MyD88)-dependent toll-like receptor (TLR) signaling, the crucial innate immune pathway in vertebrates. In the present study, the IRAK family gene IRAK-M (also called IRAK3) from grass carp (Ctenopharyngodon idella) was ...
Pengfei, Chu, Libo, He, Denghui, Zhu, Liangming, Chen, Rong, Huang, Lanjie, Liao, Yongming, Li, Zuoyan, Zhu, Yaping, Wang   +8 more
openaire   +2 more sources