IRAK signaling in cancers: mechanisms, targeting, and clinical implications. [PDF]
Expert Opin Investig DrugsVick EJ, Starczynowski DT.
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Toll-like Receptors in Inborn Errors of Immunity in Children: Diagnostic Potential and Therapeutic Frontiers-A Review of the Latest Data. [PDF]
CellsJurczuk A +4 more
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Uncovering the dynamics of extracellular vesicle microRNA trafficking in multiple sclerosis: delivery, diversion and retention. [PDF]
Extracell Vesicles Circ Nucl AcidsStevenson GC, Patil MS, Grau GER.
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IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts
Inflammation, 2022 Lung fibroblasts play an important role in subepithelial fibrosis, one feature for airway remodeling. IL-1 receptor-associated kinase (IRAK)-M was shown to involve fibrosis formation in airways and lung through regulation of inflammatory responses. IRAK-M is expressed by lung fibroblasts, whether IRAK-M has direct impact on lung fibroblasts remains ...
Zheng, Z +8 more
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Identification and characterization of murine IRAK-M
Biochemical and Biophysical Research Communications, 2002Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have ...
Michael U Martin
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Fish & Shellfish Immunology, 2019 Interleukin-1 receptor-associated kinase (IRAK) family members play important roles in myeloid differentiation primary response 88 (MyD88)-dependent toll-like receptor (TLR) signaling, the crucial innate immune pathway in vertebrates. In the present study, the IRAK family gene IRAK-M (also called IRAK3) from grass carp (Ctenopharyngodon idella) was ...
Pengfei, Chu +8 more
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MECHANISMS OF PIN1 REGULATION OF IRAK-M STABILITY IN TLR/IL-1R SIGNALING AND STRUCTURE DETERMINATION OF IRAK-M DEATH DOMAIN [PDF]
, 2018 Asthma is a chronic inflammatory sickness of the airways caused by environmental and genetic factors. The mechanisms of activation of the innate immunity signaling pathways that cause asthma are not fully understood yet. This study investigated the novel targets for the development of new asthma therapeutics.
Kwon, Jeahoo
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Cancer Cell, 2016 Colorectal cancer (CRC) is associated with loss of epithelial barrier integrity, which facilitates the interaction of the immunological microenvironment with the luminal microbiome, eliciting tumor-supportive inflammation.
Roland S Croner +2 more
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Association Between Gene Polymorphisms of IRAK-M and the Susceptibility of Sepsis
Inflammation, 2013The aim of this study was to explore the association between the single-nucleotide polymorphisms of interleukin-1 receptor-associated kinase-M (IRAK-M) gene and the susceptibility of sepsis. The allele frequency and genotype distribution of IRAK-M gene polymorphisms were assessed in 118 controls and 82 sepsis patients by semiquantitative polymerase ...
Gao-Hong, Dong +6 more
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IRAK‐M in macrophages around septically and aseptically loosened hip implants
Journal of Biomedical Materials Research Part A, 2011AbstractThe most common long‐term complication of joint arthroplasty is loosening, which is mediated by chronic inflammatory cytokines produced by macrophages stimulated by implant‐derived debris and eventually bacterial components adherent to such debris.
Yangchun, Zhang +11 more
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