Results 41 to 50 of about 9,313 (272)

Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages [PDF]

The Journal of Immunology, 2017
Abstract During macrophage activation, expression of IL-1R–associated kinase (IRAK)-M is induced to suppress TLR-mediated responses and is a hallmark of endotoxin tolerance. Endotoxin tolerance requires tight regulation of genes occurring at the transcriptional and epigenetic levels.
Konstantina Lyroni, Andreas Patsalos, Maria G Daskalaki, Christina Doxaki, Birte Soennichsen, Mike Helms, Ioannis Liapis, Vassiliki Zacharioudaki, Sotirios C Kampranis, Christos Tsatsanis   +9 more
openaire   +2 more sources

Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Reviews in Cardiovascular Medicine, 2022
Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen ...
Youjing Zheng, Jia-Qiang He
doaj   +1 more source

Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells [PDF]

, 2016
Background: Immunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer?s patches (PPMPs) and induces a differential production of pro- and anti-inflammatory cytokines in response to Toll-like receptor (TLR)-4 ...
Aso, Hisashi, Iida, Hikaru, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Ohwada, Shuichi, Saito, Tadao, Suda, Yoshihito, Takahashi, Takuya, Tsukida, Kohichiro, Villena, Julio Cesar   +13 more
core   +3 more sources

IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis. [PDF]

BMC Microbiol, 2017
Intracellular bacterium, Mycobacterium tuberculosis (M. tb), infects specifically macrophages as host cells. IRAK-M, a member of IRAK family, is a negative regulator in TLR signaling and specifically expresses in monocytes and macrophages. The role of IRAK-M in intracellular growth of M.
Shen P, Li Q, Ma J, Tian M, Hong F, Zhai X, Li J, Huang H, Shi C.   +8 more
europepmc   +3 more sources

Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts. [PDF]

Arterioscler Thromb Vasc Biol, 2012
Objective— Effective postinfarction repair requires timely suppression of innate immune signals to prevent the catastrophic consequences of uncontrolled inflammation on cardiac geometry and function. In macrophages, interleukin-1 receptor-associated kinase (IRAK)-M acts as a functional decoy preventing uncontrolled toll-like ...
Chen W, Saxena A, Li N, Sun J, Gupta A, Lee DW, Tian Q, Dobaczewski M, Frangogiannis NG.   +8 more
europepmc   +4 more sources

Intestinal fungi contribute to development of alcoholic liver disease [PDF]

, 2017
This study was supported in part by NIH grants R01 AA020703, U01 AA021856 and by Award Number I01BX002213 from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development (to B.S.). K.H.
Ali Keshavarzian, An-Ming Yang, Bernd Schnabl, Bode, Chien-Sheng Chen, Claus Hellerbrand, Cristina Llorente, Derrick E. Fouts, Ece A. Mutlu, Fettweis, Fouts, Gordon D. Brown, Guadalupe Garcia-Tsao, Hal M. Hoffman, Jun Xu, Karen Beeri, Katrin Hochrath, Kelvin Moncera, Kim Freese, Lee, Lirui Wang, Liu, Manolito G. Torralba, Peng Chen, Peter Stärkel, Phillipp Hartmann, Ramon Bataller, Samuel B. Ho, Sena Bluemel, Serene M.L. Lee, Sokol, Tatiana Kisseleva, Tatsuo Inamine, Wagner, Wajahat Z. Mehal, Yamahiro, Yang, Yukinori Koyama   +37 more
core   +3 more sources

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. [PDF]

J Immunol, 2015
Abstract Idiopathic pulmonary fibrosis is a devastating lung disease characterized by inflammation and the development of excessive extracellular matrix deposition. Currently, there are only limited therapeutic intervenes to offer patients diagnosed with pulmonary fibrosis.
Ballinger MN, Newstead MW, Zeng X, Bhan U, Mo XM, Kunkel SL, Moore BB, Flavell R, Christman JW, Standiford TJ.   +9 more
europepmc   +4 more sources

Evaluation of the immunomodulatory activities of the probiotic strain lactobacillus fermentum UCO-979C [PDF]

, 2019
Lactobacillus fermentum UCO-979C, a strain isolated from a human stomach, was previously characterized by its potential probiotic properties. The UCO-979C strain displayed the ability to beneficially regulate the innate immune response triggered by ...
Alvarez, Gladis Susana, Clua, Maria Patricia, Garcia Cancino, Apolinaria, Garcia Castillo, Valeria, Indo, Yuhki, Islam, M. Aminul, Kitazawa, Haruki, Komatsu, Ryoya, Salva, Maria Susana, Takagi, Michihiro, Takahashi, Hideki, Villena, Julio Cesar   +11 more
core   +1 more source

Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression [PDF]

The Journal of Immunology, 2009
Abstract High levels of plasma adiponectin are associated with low levels of inflammatory markers and cardioprotection. The mechanism via which adiponectin exerts its anti-inflammatory effect is yet unknown. In the present study, we demonstrate that globular adiponectin (gAd) induces the expression of the inactive isoform of IL-1R ...
Vassiliki, Zacharioudaki, Ariadne, Androulidaki, Alicia, Arranz, George, Vrentzos, Andrew N, Margioris, Christos, Tsatsanis   +5 more
openaire   +2 more sources

IL-23 production in human macrophages is regulated negatively by tumor necrosis factor α-induced protein 3 and positively by specificity protein 1 after stimulation of the toll-like receptor 7/8 signaling pathway

Heliyon, 2022
The IL-23/IL-17 axis plays an important role in the development of autoimmune diseases, but the mechanism regulating IL-23 production is mainly unknown.
Rui Yamaguchi, Arisa Sakamoto, Reona Yamaguchi, Misa Haraguchi, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguch   +6 more
doaj   +1 more source