Results 81 to 90 of about 37,349 (239)

NOG1 impairs the DNA binding ability of IRF3.

, 2023
HEK-293T cells transfected with increasing Flag-NOG1 expression plasmid (0, 1, and 3 μg) (A), and WT and NOG1+/- HEK-293T cells (B and C) were infected with SeV for 12 h. Chromatin was immunoprecipitated with an anti-IRF3 antibody.
Weijun Cao (122575), Haixue Zheng (286790), Zixiang Zhu (280085), Fan Yang (1413), Huisheng Liu (408091), Xiangtao Liu (286800), Qiao Xue (431091), Zhaoning Xue (14564656)   +7 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation

, 2018
TANK-binding kinase 1 (TBK1) is an important serine/threonine-protein kinase that mediates phosphorylation and nuclear translocation of IRF3, which contributes to induction of type I interferons (IFNs) in the innate antiviral response.
Yi Wei Hu, Ming Xian Chang, Pin Nie, Wu, Xiao Man, Xiao Man Wu, Cao, Lu, Nie, Pin, Jie Zhang, Lu Cao, Chang, Ming Xian, Zhang, Jie, Hu, Yi Wei   +11 more
core   +2 more sources

Nuclear translocation of IRF3 in BKV infected LVEC.

, 2019
A. Double staining of VP1 and IRF3 showed nuclear localization of IRF3 in BKV inoculated (lower panel) but not mock (upper panel) LVEC3. B. Nuclear IRF3 was not detected in BKV infected RPTE1 by IF.
Ping An (24129), Alexis M. Duray (3691942), James M. Pipas (201349), Maria Teresa Sáenz Robles (201330), Paul G. Cantalupo (6185180)   +4 more
core   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.

PLoS Pathogens, 2010
The mucosal immune system identifies and fights invading pathogens, while allowing non-pathogenic organisms to persist. Mechanisms of pathogen/non-pathogen discrimination are poorly understood, as is the contribution of human genetic variation in disease
Hans Fischer, Nataliya Lutay, Bryndís Ragnarsdóttir, Manisha Yadav, Klas Jönsson, Alexander Urbano, Ahmed Al Hadad, Sebastian Rämisch, Petter Storm, Ulrich Dobrindt, Ellaine Salvador, Diana Karpman, Ulf Jodal, Catharina Svanborg   +13 more
doaj   +1 more source

IRF3 and TBK1 are related to EV-A71 replication.

, 2023
(A) Changes of phosphorylated TBK1 and IRF3 after EV-A71 infection, MOI = 1. (B) Overexpression of IRF3 (Synthesized by Shenzhen BGI Co., LTD) and IRF3 agonist (100 nmol/L) could decrease the VP1 expression of EV-A71.
Wangquan Ji (10887180), Shuaiyin Chen (3816457), Yuefei Jin (4722396), Guangcai Duan (517687), Haiyan Yang (659313), Dong Li (212687), Tiantian Sun (154175)   +6 more
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture

Journal of Inflammation Research
Tyler C Moore,1 Terrence Scott Pinkerton,1 Thomas M Petro2 1Department of Biology, College of Science and Technology, Bellevue University, Bellevue, NE, 68005, USA; 2Department of Oral Biology, University of Nebraska Medical Center, Lincoln, NE, 68583 ...
Moore TC, Pinkerton TS, Petro TM
doaj  

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source